Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator

Carvalho-Netto, Eduardo F.; Gomes, Keila Rejane Oliveira; Amaral, Vanessa Cristiane Santana; Nunes-de-Souza, Ricardo Luiz

doi:10.1007/s00213-009-1492-9

Cited by 22 publications

(9 citation statements)

References 56 publications

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“…Microinjection into the dlPAG of drugs that impair NOmediated neurotransmission, such as c-PTIO, NOS inhibitors or soluble guanylyl cyclase inhibitors, produced anxiolytic-like effects in different animal models, suggesting that NO facilitates anxiety responses in this region [26,28,43,44,45]. In agreement with this proposal, dlPAG microinjection of NO donors induced pro-aversive effects such as flight reactions [46,47,48].…”

Section: Discussionsupporting

confidence: 69%

The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors

Batista

Fogaça

Guimarães

2015

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 69%

The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors

Batista

Fogaça

Guimarães

2015

Behavioural Brain Research

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“…The gaseous signaling molecule nitric oxide (NO) is also implicated in defensive responses involving the PAGd. Specifically, injection into the PAGd of an inhibitor of neuronal nitric oxide synthase (NOS) was shown recently to reduce defensive behavioral responses of mice exposed to rats (Carvalho-Netto et al, 2009); furthermore, an increase in defensive responses produced by injection of the ionotropic glutamate receptor agonist NMDA into the PAGd was prevented by prior injection (into the PAGd) of the NOS inhibitor (Carvalho-Netto et al, 2009). In this context, it is noteworthy that an abundant population of NO-synthesizing neurons is present in (and in fact delineates) the PAGdl (Onstott et al, 1993).…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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“…Conversely, intra-dPAG injection of NOS inhibitors, guanylate cyclase inhibitors and an NO scavenger provokes anxiolytic-like effects in rats exposed to the elevated plus-maze (12). In mice, intra-PAG injection of a highly selective and potent nNOS inhibitor, N ω -propyl-L-arginine (NPLA), attenuates defensive behavior in the rat exposure test, a prey-predator interaction test (13), and reverses both the defensive-like behavior and the antinociception induced by local infusion of NMDA (1). These results are consistent with previous findings indicating that there are a large number of NOS immunoreactive neurons in the dPAG of rats and mice (14, 15).…”

Section: Introductionmentioning

confidence: 99%

Contrasting effects of nitric oxide and corticotropin- releasing factor within the dorsal periaqueductal gray on defensive behavior and nociception in mice

Miguel

Gomes

Nunes-de-Souza

2012

Braz J Med Biol Res

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The anxiogenic and antinociceptive effects produced by glutamate N-methyl-D-aspartate receptor activation within the dorsal periaqueductal gray (dPAG) matter have been related to nitric oxide (NO) production, since injection of NO synthase (NOS) inhibitors reverses these effects. dPAG corticotropin-releasing factor receptor (CRFr) activation also induces anxiety-like behavior and antinociception, which, in turn, are selectively blocked by local infusion of the CRF type 1 receptor (CRFr1) antagonist, NBI 27914 [5-chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine]. Here, we determined whether i) the blockade of the dPAG by CRFr1 attenuates the anxiogenic/antinociceptive effects induced by local infusion of the NO donor, NOC-9 [6-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine], and ii) the anxiogenic/antinociceptive effects induced by intra-dPAG CRF are prevented by local infusion of Nω-propyl-L-arginine (NPLA), a neuronal NOS inhibitor, in mice. Male Swiss mice (12 weeks old, 25-35 g, N = 8-14/group) were stereotaxically implanted with a 7-mm cannula aimed at the dPAG. Intra-dPAG NOC-9 (75 nmol) produced defensive-like behavior (jumping and running) and antinociception (assessed by the formalin test). Both effects were reversed by prior local infusion of NBI 27914 (2 nmol). Conversely, intra-dPAG NPLA (0.4 nmol) did not modify the anxiogenic/antinociceptive effects of CRF (150 pmol). These results suggest that CRFr1 plays an important role in the defensive behavior and antinociception produced by NO within the dPAG. In contrast, the anxiogenic and antinociceptive effects produced by intra-dPAG CRF are not related to NO synthesis in this limbic midbrain structure.

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Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator

Abstract: These findings suggest a potential role of glutamate NMDA receptors and NO in the dPAG in the regulation of defensive behaviors in mice during a confrontation with a predator in the RET.

Cited by 22 publications

References 56 publications

The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors

The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Contrasting effects of nitric oxide and corticotropin- releasing factor within the dorsal periaqueductal gray on defensive behavior and nociception in mice

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