Benzimidazole: A short review of their antimicrobial activities

Abstract

Benzimidazole is the heterocyclic compound formed from benzene and imidazole ring containing nitrogen, oxygen sulphor and its derivatives are of wide interest because of their diverse biological activity and clinical applications, they are remarkably effective compounds both with respect to their inhibitory activity and their favourable selectivity ratio. Reported nucleus is a constituent of vitamin-B12. Benzimidazoles are regarded as a promising class of bioactive heterocyclic compounds that exhibit a range of biological activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous anti-oxidant, anti-parasitic, anti-helmintics, anti-proliferative, anti-HIV, anti-convulsant, anti-inflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. Benzimidazoles exhibit significant activity as potential antitumor agents, smooth muscle cell proliferation inhibitors, a treatment for intestinal cystitis, and in diverse area of chemistry. Some of the important benzimidazole derivatives have been reported as thyroid receptor agonist gonadotropin releasing hormone receptor antagonists, non-nucleoside HIV-1 reverse transcriptase inhibitors and interestingly alkynylbenzimidazoles as modulators of metabotropic glutamate receptors. The imidazole core is a common moiety in a large number of natural products and pharmacologically active compounds. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research. This comprehensive overview summarizes the chemistry of different derivative of substituted benzimidazole along with their anti-microbial activity containing anti-malarial anti-fungal, anti-bacterial, anti-viral activities.DOI: http://dx.doi.org/10.3329/icpj.v1i5.10284International Current Pharmaceutical Journal 2012, 1(5): 119-127

Antimicrobial Activity of 2-Nitro-6-[(4-Phenyl-Benzo[4,5]imidazo[1,2-a] Pyrimidin-2-ylimino)-Methyl]-Phenol: A Novel Schiff Base Compound

“…No undesired proton was recorded on the spectrum. 13 C NMR spectrum of the prepared Schiff base LH1 showed characteristic signals of imine and aromatic carbon atoms in the expected ranges of chemical shift values. At δ = 161.85 and δ = 161.35 ppm, the imine groups (C=N-C) and (C=N-H) are observed.…”

“…Today it is a moiety of choice which possesses many biological applications and clinical properties [12]. Several derivatives of benzimidazole have been recorded together with their biological importance [13]. Benzimidazole and its derivatives have the capacity to interfere several microbial metabolic processes that in turn affect their growth and sometimes leading to cell death.…”

Evaluating the biological potential of some new cobalt (II) complexes with acrylate and benzimidazole derivatives

“…A literature survey shows that benzimidazole/benzimidazole derivatives and their complexes present antimicrobial, antiviral, antidiabetic, anticancer activities, superoxide dismutase mimetic activity and catalytic activity …”

Development and validation of RP-HPLC method for the estimation of omeprazole in bulk and capsule dosage forms

“…Omeprazole (Namrata singh et al, 2012;Indian Pharmacopoeia., 2010; United States of Pharmacopoeia 2009) (RS)-6-methoxy-2-((4-methoxy-3, 5-dimethylpyridin-2-yl) methyl sulfinyl)-1H-benzo (d) imidazole is a proton pump inhibitor (PPI) and an anti-secretory compound. It suppresses gastric acid secretion by inhibiting the gastric H + /K + ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell.…”