Benzamide Derivatives as Potential Candidates for Anti-Alzheimer, Anti-Fatigue, Anti-Urease and Anti-Oxidant Activity

Abstract

Benzamide derivatives were screened for their anti-alzheimer, anti-fatigue, anti-urease and anti-oxidant activity and their results were calculated in the form of %age inhibition and IC 50 value. Compounds 3a and 3g exhibited the highest anti alzheimer activity. Group of mice's treated by compounds 3f and 3g showed significantly longer swimming times than those of the treated with caffeine. The prominent urease inhibitory activity was shown by only one compound among seven benzamide derivatives. Controlled experiments suggest that benzamide derivatives (3a-3g) can be serve as the therapeutic agents

Exploring novel fluorine-rich fuberidazole derivatives as hypoxic cancer inhibitors: Design, synthesis, pharmacokinetics, molecular docking, and DFT evaluations

“…The in-vitro antioxidant free radical scavenging potential of the fuberidazole derivatives ( 5a - 5p ) was assessed utilizing a reduction method DPPH (2,2-diphenyl-1-picryl hydrazyl) with the slightly modified protocol [ 21 , 22 ]. The stock methanolic solution of DPPH was prepared (4 mg DPPH/4 mL MeOH) and further dilutions were also prepared at concentrations: 1.0, 2.0, 4.0, 8.0, 16.0, 32.0, 64.0, 128, 256, and 500 μg/mL.…”

2‐Aminothiazole‐Oxadiazole Bearing N‐Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure‐Activity Relationship, and Binding Conformations

“…Thus, the designed derivatives, 7a-h were achieved in good yields with of excellent level purity. The structures of the synthesized compounds were characterized through IR, 1 H-NMR, 13 C-NMR, EI-MS and CHN analysis data.…”

“…In chemical bonds, amide bond is one of the most abundant bonds and it extensively exists in numerous biomolecules and organic molecules [12] . It is an important pharmacophore group existing in an extensive range of therapeutically significant drugs, e. g., phosphoramide, buspirone and ampakine compounds [13] . It is also presented in enormous number of industrial constituents including lubricants, polymers, and detergents.…”

“…[12] It is an important pharmacophore group existing in an extensive range of therapeutically significant drugs, e. g., phosphoramide, buspirone and ampakine compounds. [13] It is also presented in enormous number of industrial constituents including lubricants, polymers, and detergents. Normally, amides are classified into distinctive subclasses depending upon the number of nitrogen substituents.…”

Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine

“…30 Cetirizine is usually restrained from crossing the blood-brain barrier and, consequently, has diminished impact on the central nervous system in contrast to first-generation drugs, for example, it has less possibility to induce sleepiness or to interfere with memory creation. 31 Keeping in mind the above aspects and in continuation of previous research work, [32][33][34][35][36][37] herein the synthesis and biological activities of organotin(IV) complexes of flumequine and cetirizine are reported to evaluate further their biological significance in comparison to their previous function as patent drugs.…”