Benoxaprofen: A new arthritis medication that causes phototoxicity

Greist, Mary C.; Norins, Arthur L.

doi:10.1016/s0190-9622(82)80239-9

Cited by 7 publications

(3 citation statements)

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“…We have therefore postulated that the absence or rareness of spontaneous photoonycholysis in people with darker skin types is due to presence of melanin, providing some degree of natural photoprotection to the nail bed. However, paradoxically the incidence of photoonycholysis has been higher in darkly pigmented individuals on benoxaprofen whose pigmentation has allowed them to get regular exposure to sunlight . Nevertheless, our enquiries at a number of American universities dealing predominantly with African Americans suggest that drug‐induced photoonycholysis was not recognized as a problem perhaps because the melanosomes of these subjects have a protective effect, as variations in racial pigmentation are due to the number and size of melanosomes produced.…”

Section: Spontaneous Photoonycholysismentioning

confidence: 83%

“…However, paradoxically the incidence of photoonycholysis has been higher in darkly pigmented individuals on benoxaprofen whose pigmentation has allowed them to get regular exposure to sunlight. 33 Nevertheless, our enquiries at a number of American universities dealing predominantly with African Americans suggest that drug-induced photoonycholysis was not recognized as a problem perhaps because the melanosomes of these subjects have a protective effect, as variations in racial pigmentation are due to the number and size of melanosomes produced. Moreover, in Caucasians a few melanosomes are of the melanized type IV (opaque to electrons) although in non-Caucasians they are abundant before irradiation.…”

Section: Spontaneous Photoonycholysismentioning

confidence: 94%

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Photoonycholysis: new findings

Baran

Mascaró

Aguilera

2018

Acad Dermatol Venereol

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First described in 1961, photoonycholysis (PO) is a rare nail alteration that may result from drug intake, from topical aminolevulinate photodynamic therapy or from photosensitive conditions such as porphyria or pseudoporphyria. Spontaneous PO is rare. This review updates the numerous causes of PO and highlights some new ways producing this condition. Four different types of PO are clearly recognized without relationship with the responsible drug. An updated list of potential inducing drug is provided. Some practical points on PO have been raised. The inability to reproduce photoonycholysis experimentally should be emphasized, and the pathogenesis of PO still needs to be clarified.

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Section: Spontaneous Photoonycholysismentioning

confidence: 83%

Section: Spontaneous Photoonycholysismentioning

confidence: 94%

Photoonycholysis: new findings

Baran

Mascaró

Aguilera

2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…We have therefore postulated that the absence or paucity of spontaneous photoonycholysis in people with darker skin types is due to presence of melanin, providing some degree of natural protection to the nail bed. However, the incidence of photoonycholysis has been greatest in darkly pigmented individuals on benoxaprofen whose pigmentation has allowed them to get regular exposure to bright sunlight (24). Nevertheless, our inquiries at number of American universities dealing predominantly with African‐ Americans suggested that drug‐induced photoonycholysis was not recognized as a problem, which reinforced our opinion.…”

Section: Other Causes Of Photoonycholysismentioning

confidence: 99%