Benign Type of Acanthosis Nigricans

Acanthosis nigricans in achondroplasia

“…(Note, however, that in none of these publications is there adequate clinical or radiographic documentation of the absence of features of hypochondroplasia, and at least some of the affected individuals were of modest small stature (Berk et al, ; Fukuchi et al, ). It is possible that the long‐recognized, rare, autosomal dominant familial AN (Curth, ) is identical to that described in these reports.…”

Malignant acanthosis nigricans--a para-endocrine syndrome?

“…The dermatosis a. n. was classified in both benign and malignant forms by Curth (2). Many theories have been propounded with respect to the etiology of the disease and although Curth (3) described the macroscopic and microscopic identities of the two types, which suggested an identical origin, she later…”

“…Acanthosis nigricans (a. n.) is a hyperpigmented, verrucose and hyperkeratotic dermatosis primarily affecting the flexural areas of the body. It occurs in two types (2) the malignant type associated with a cancer of an interna! organ, and the benign type, not so associated.…”

Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

“…[4][5][6][7][8] Furthermore, there are reports of benign, generalized AN in early childhood without a positive family history, malignancy, associated syndrome, causative medication, or comorbid condition. [9][10][11][12][13][14][15] Only a few families with isolated (nonsyndromic, noninsulin resistance-associated) familial AN have been reported in the literature. [4][5][6][7][8] Inheritance tends to be autosomal dominant with variable penetrance.…”