Benign Type of Acanthosis Nigricans

Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

“…[4][5][6][7][8] Furthermore, there are reports of benign, generalized AN in early childhood without a positive family history, malignancy, associated syndrome, causative medication, or comorbid condition. [9][10][11][12][13][14][15] Only a few families with isolated (nonsyndromic, noninsulin resistance-associated) familial AN have been reported in the literature. [4][5][6][7][8] Inheritance tends to be autosomal dominant with variable penetrance.…”

Acanthosis Nigricans Juvenilis Associated With Obesity

“…Wieder expressed the opinion that hypofunction of suprarenal glands increases tolerance for sugar, because in his case acanthosis nigricans was associated with impairment of secretion of the ductless glands, particularly the suprarenals. Curth,13 although stating that there is no basis for assuming an endocrine causation in the benign type of the disease, expressed the belief that the common onset and spread of acanthosis nigricans in and through puberty is evi¬ dence in favor that "sex hormones play some role in the propagation of the disease." We are in agreement writh the foregoing findings and opin¬ ions of investigators favoring the relationship of dysfunction of the endo¬ crine glands to benign acanthosis nigricans.…”

Helen Ollendorff Curth and William Curth: From Breslau and Berlin to Bar Harbor

“…Her classic papers in the Archives of Dermatology, starting in 1936, 5 and her marvelous contribution to the first edition of Fitzpatrick's Dermatology in General Medicine 6 are both still frequently cited and well worth reading. She realized that acanthosis nigricans was a sign, not a specific disease.…”