Acanthosis Nigricans Juvenilis Associated With Obesity

Robinson, Saul S.; Tasker, Samuel

doi:10.1001/archderm.1947.01520060011002

Cited by 13 publications

(2 citation statements)

References 7 publications

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“…Estrogen, including oral contraceptives and di-ethylstUbestrol, and other hormonal factors may induce AN (2,4,6,13). The appearance of the disease with the onset of puberty has been attributed to increased levels of sex steroids (7). Randle and Winkelmann (4) reported it occurring eight years after triamcinolone therapy for polymyositis.…”

Section: Discussionmentioning

confidence: 99%

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Remission of Acanthosis Nigricans, Hypertrichosis, and Hashimoto's Thyroiditis with Thyroxine Replacement

Fuenning

1986

Pediatric Dermatology

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Hypothyroidism is not commonly associated with acanthosis nigricans (AN). We examined a 13-year-old girl with AN, hypertrichosis, and Hashimoto's thyroiditis. Overt biochemical hypothyroidism, thyroid enlargement, and positive titers of antimicrosomal and antithyroglobulin antibodies confirmed Hashimoto's thyroiditis. Both AN and hypertrichosis resolved with thyroid hormone replacement. There was no evidence of insulin resistance, polycystic ovarian disease, lipoatrophy, or other endocrine dysfunction, or of malignancy. In two patients from the literature with AN and hypothyroidism, AN was attributed to associated thyroid carcinoma or insulin resistance, rather than coexisting hypothyroidism. Since the skin lesions improved with thyroid hormone therapy in those two patients and in ours, hypothyroidism appears to be directly involved in the pathogenesis of AN.

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Section: Discussionmentioning

confidence: 99%

“…Other hormonal medications, including estrogens and glucocorticoids, may induce AN (2)(3)(4)6). The appearance of AN with the onset of puberty has been attributed to increased levels of sex steroids (7). Pituitary and other peptides have also been implicated in the pathogenesis (3).…”

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confidence: 99%