Benign teratomas of the mediastinum

Lewis, Bradley D.; Hurt, R. Douglas; Payne, W. Spencer; Farrow, George M.; Knapp, Robert H.; Muhm, John R.

doi:10.1016/s0022-5223(19)39090-7

Cited by 221 publications

(88 citation statements)

References 4 publications

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“…There were nine benign teratomas (69.2%) and four malignant GCTs (30.8%), including one seminoma and three nonseminomas. The frequency of malignancy was similar to that in Japan [5,16], but slightly lower than that in the USA (39.4%) and Europe (40.8%) [17][18][19]. There were some differences in clinical characteristics between benign teratomas and malignant GCTs.…”

Section: Discussionsupporting

confidence: 64%

Poor Outcomes in Patients with Primary Malignant Mediastinal Germ‐cell Tumors

Hsiao

Liu

Tsai

et al. 2005

The Kaohsiung J of Med Scie

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Primary mediastinal germ-cell tumors (GCTs) without gonadal involvement are rare and can be divided into benign mature teratoma and malignant seminoma or nonseminoma. We describe our experience of malignant mediastinal GCTs and compare the presentations and outcome with those of benign teratomas. Four malignant GCTs (1 seminoma, 1 choriocarcinoma, and 2 yolk-sac tumors) have been treated in our hospital. All patients were men with obvious symptoms before diagnosis. The patient with seminoma was treated with surgery and radiation, while those with nonseminoma tumors were treated with chemotherapy and/or surgery. Two patients died, one with extended pulmonary metastasis and the other with relapsed disease and high levels of tumor markers. Compared with the nine cases of benign teratomas, the four malignant GCTs showed overwhelming male dominance, advanced symptoms at presentation, and poor outcome. These cases highlight the important role of disease staging and tumor-marker levels in malignant GCTs, and suggest that new treatment strategies for malignant GCTs await further investigation.

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Section: Discussionsupporting

confidence: 64%

Poor Outcomes in Patients with Primary Malignant Mediastinal Germ‐cell Tumors

Hsiao

Liu

Tsai

et al. 2005

The Kaohsiung J of Med Scie

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“…Nonetheless, such tumors have also been described in other locations, such as the pineal gland, retroperitoneum, mediastinum, and sacral area 2‐4. Germ cell tumors arising primarily in the mediastinum are uncommon and have mostly been the subject of case reports; very few comprehensive studies on this topic have been reported in the literature 2, 4‐103. It has been estimated in some studies that extragonadal germ cell tumors account for approximately 1‐15% of mediastinal tumors in adults and approximately 25% in children 21, 59, 60, 104…”

mentioning

confidence: 99%

Primary germ cell tumors of the mediastinum

Moran

Suster

1997

Cancer

238

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“…The mature cystic teratoma is generally benign, but both immature and mature types may show malignant transformation, resembling a non‐germ cell tumor (GCT) somatic‐type cancer. Additionally, in categorizing malignant germ cell tumors, alpha feto protein and human chorionic gonadotropin (HCG) evaluation are useful in differentiating seminomas from nonseminomatous tumors, assessing response to therapy in hormonally active tumors and diagnosing relapse or failure to therapy 2,5,8…”

Section: Discussionmentioning

confidence: 99%

Intrapericardial Mature Cystic Teratoma in an Adult: Case Presentation

Cohen

Mirrer

Loarte

et al. 2012

Clinical Cardiology

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Cardiac Teratoma is a tumor of very rare occurrence in adult population. Here we report a case in a Caucasian male with history of Human immunodeficiency virus infection where the symptom as presentation was recurrent episodes of tachycardia. The chest radiograph showed a lesion in the right heart border and subsequent investigation revealed an intrapericardial lesion, which was demonstrated to be a pericardial teratoma diagnosed by histopathology. In this case the initial differential diagnosis included lymphoma or an infectious organism as possible causes in a immunocompromised patient. Cardiac teratomas are among the less common types of cardiac tumors being more frequent in child population and around 1% of all the cardiac tumors in adults. Imaging studies are very helpful. CT and MRI are the best due to their resolution and ability to assess the relationship of the mass with the surrounding structures. Echocardiogram in also helpful determining the presence of pericardial effusion because cardiac teratomas are most of the time present in the pericardium. The final diagnosis is mostly made after surgical excision and this is the most effective treatment because they are relatively resistant to chemotherapy and radiotherapy. IntroductionTeratomas are tumors of embryonic origin composed of elements derived from the 3 germinal layers in varying degrees. 1 If more than 50% of the tumor is comprised of well-differentiated elements, then the tumor is referred to as a mature teratoma. Intrapericardial teratomas are rare. Nonetheless, approximately 55 to 65 cases of intrapericardial teratomas have been reported in the literature up to the year 2001. Ninety percent of the cardiac teratomas have been found in the pericardium and the rest in the myocardium.

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Benign teratomas of the mediastinum

Cited by 221 publications

References 4 publications

Poor Outcomes in Patients with Primary Malignant Mediastinal Germ‐cell Tumors

Poor Outcomes in Patients with Primary Malignant Mediastinal Germ‐cell Tumors

Primary germ cell tumors of the mediastinum

Intrapericardial Mature Cystic Teratoma in an Adult: Case Presentation

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