Primary germ cell tumors of the mediastinum

Moran, César A.; Suster, Saul

doi:10.1002/(sici)1097-0142(19970815)80:4<681::aid-cncr6>3.0.co;2-q

Cited by 238 publications

(97 citation statements)

References 87 publications

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“…An alternative explanation, reported both by Guo et al 6 intracranial cavity too. 16 The somatic neoplasia may not only be an adenocarcinoma or squamous cell carcinoma, 17 or more frequently sarcoma of any type, 6,8 but also PNETs, 18-21 nephroblastoma, 22,23 carcinoids, 24 angiosarcoma, 15 and hematologic malignancies have been reported in previous as well as in this series. 10 The commonest reported histologic subtype of TSMC is rhabdomyosarcoma 6 as a single tumor type or admixed with other sarcomatous hystotypes.…”

Section: Discussionsupporting

confidence: 65%

Teratoma With Somatic-Type Malignant Components in Germ Cell Tumors of the Testis: A Clinicopathologic Analysis of 40 Cases With Outcome Correlation

et al. 2010

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Teratoma with a malignant somatic component (MSC) is a rare phenomenon recognized when a somatic type malignancy occurs in the context of a germ cell tumor (GCT). The authors present their 29-year experience with 40 patients treated from 1981 to 2009 in their institution. The average age was 31 years. All patients underwent radical orchiectomy, which demonstrated a GCT in 19 with an MSC. The MSC was observed in the other 21 cases in metastatic sites, including lung (13), liver (3), pleura (1), mediastinum (7), supraclavicular lymph nodes (1), and retroperitoneal lymph nodes (9). The most common histologic types were rhabdomyosarcoma (n = 11) and primitive neuroectodermal tumors (n = 10), followed by adenocarcinoma (n = 9), sarcoma, not otherwise specified (n = 5), well-differentiated liposarcoma (n = 2), leiomyosarcoma (n = 2), chondrosarcoma (n = 2), nephroblastoma (Wilms's tumor), carcinoid, malignant peripheral nerve sheath tumor, and a gemistiocytic astrocytoma with choroid plexus tumor (each n = 1). Clinical data were collected through a dedicated database and are available for all 40 cases. After a median follow-up of 37 months, 29/40 (72.5%) were alive and disease-free. Stage-specific survival was 100% for stage I, 87.5% for stage II, and 53% for stage III patients suggesting that patients with MSC confined to the testis have a good prognosis. A lower sensitivity to chemotherapy for a MSC when compared with typical GCT is reported. Surgical excision of the MSC is therefore an essential part of the management.

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Section: Discussionsupporting

confidence: 65%

Teratoma With Somatic-Type Malignant Components in Germ Cell Tumors of the Testis: A Clinicopathologic Analysis of 40 Cases With Outcome Correlation

et al. 2010

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“…1 Teratomatous lesions also represent the most frequent type of primary germ cell tumor in the mediastinum. 6 This case of a concurrent mediastinal and retroperitoneal mature teratoma across a congenital diaphragmatic defect, conforms to the chronology of events, during the cephalad migration of the primordial germ cells (between wk 5 and 6) through the developing diaphragm, prior to its complete closure (by wk 8-10 of gestation).…”

Section: Discussionsupporting

confidence: 76%

Thoraco-abdominal mature teratoma in a left diaphragmatic hernia

et al. 2010

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“…A variety of somatic malignancies in GCT can occur in neoplasms of gonads, as well as in germinal extragonadal tumors of the mediastinum [19] and intracranial cavity [20]. The somatic neoplasia may be sarcomas of any type [2,3,5,7,8,10,[21][22][23][24][25][26].…”

Section: Histopathologymentioning

confidence: 99%

Teratoma with somatic-type malignant components of the testis. A review and an update

Mikuz

Colecchia

2012

Virchows Arch

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Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease.

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Primary germ cell tumors of the mediastinum

Abstract: RESULTS.The overwhelming majority of patients were men (320); only 2 were women (both had teratomatous lesions with additional malignant components).

Cited by 238 publications

References 87 publications

Teratoma With Somatic-Type Malignant Components in Germ Cell Tumors of the Testis: A Clinicopathologic Analysis of 40 Cases With Outcome Correlation

Teratoma With Somatic-Type Malignant Components in Germ Cell Tumors of the Testis: A Clinicopathologic Analysis of 40 Cases With Outcome Correlation

Thoraco-abdominal mature teratoma in a left diaphragmatic hernia

Teratoma with somatic-type malignant components of the testis. A review and an update

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