Benign symmetrical lipomatosis with mediastinal involvement and growth retardation

The use of high tumescent power assisted liposuction in the treatment of Madelung’s collar

“…From the histopathological point of view, MSL fat cells are smaller than normally present in adipose tissue, suggesting hyperplasia [ 14 ]. An increase of so-called tumor is also noted as the proliferation index, also described as a morphological intermediate form between lipoma and liposarcoma [ 7 ]. Isolated adipocytes have increased lipoprotein lipase activity, while pointing out to the defect of lipolysis stimulated by adrenergic receptors.…”

Malignant transformation of Madelung’s disease in a patient with a coincidental diagnosis of breast cancer: a case report

“…A more in-depth analysis of molecular pathways associated with MSL would open novel perspectives in terms of disease management and understanding of pathogenesis: indeed, MSL adipocytes have been proposed to originate from the brown adipose tissue precursors given the similarity of morphological appearance and expression of specific molecular markers, such as the mitochondrial inner protein UCP-1 [11]. Moreover, MSL adipocytes exhibit an increased, so-called tumor-like, proliferation rate, and have been described as showing intermediate morphological features between lipoma and liposarcoma [12]. Whether the mutations of mitochondrial DNA described in MSL adipocytes are directly responsible of the increased growth rate [13] or are just an epiphenomenon of disturbances of other metabolic pathways remains to be established.…”

Multiple Symmetric Lipomatosis

“…20 These complications result from compression of the laryngotracheal region, recurrent laryngeal nerve, 8,21 and mediastinal structures, such as the superior vena cava, causing superior vena cava syndrome. 8,22 The course is usually indolent, slowly progressive over months or years, although there are reports of much faster evolution. 8,23 Peripheral polyneuropathy has also been described and has often been attributed to alcohol toxicity.…”

“…20 These complications result from compression of the laryngotracheal region, recurrent laryngeal nerve, 8,21 and mediastinal structures, such as the superior vena cava, causing superior vena cava syndrome. 8,22…”