Benign prostatic hyperplasia and male lower urinary symptoms: A guide for family physicians

Vasanwala, Farhad Fakhrudin; Wong, Margaret Wan Nar; Ho, Henry Sun Sien; Foo, Keong Tatt

doi:10.1016/j.ajur.2017.05.003

Cited by 20 publications

(16 citation statements)

References 3 publications

(4 reference statements)

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“…13,14 Age related LUTS\BPH was mentioned by Weiyu Zhang et al while beside the age related LUTS, the role of the medical management of BPH and decreasing the resultant LUTS were also reported by Farhad Fakhrudin and colleagues. 15,16 Improvement of LUTS and inconsequence depression, anxiety and psychiatric morbidity was documented for both medical and surgical treatment by Kia Fatt Quek et al (in the contrary of our study). 17 Finally, Kia Fatt Quek et al in another study, supported our thoughts about the superiority of TURP in minimizing psychological morbidities in patients with LUTS secondary to BPH.…”

Section: Discussioncontrasting

confidence: 49%

Treatment of psychological morbidity secondary to benign prostatic hyperplasia: a comparative study

et al. 2020

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Background: Authors tend to compare the medical treatment of benign prostatic hyperplasia with the surgical option regarding lower urinary tract symptoms (LUTS) and related psychological morbidity.Methods: A retrospective study of (1614) patients who were managed by either transurethral resection of prostate (TURP) or medical treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH) over a period of 5 years between (Sep. 2013 and Sep. 2018) carried out in Prince Hussein Urology Center at Jordanian Royal Medical Services. Patients were classified into two groups, group1 (807 patients) who get a medical option and group 2 (807 patients who underwent TURPs. A comparison between both groups according to the effect of minimizing the psychological morbidities was done over a period of 1-year follow-up after reviewing the patient’s medical records.Results: Ages of the patients for group1 and 2 were (47-68 years), (49-73 years), respectively. There were significant differences at the level of depression, anxiety and psychiatric morbidity pre-treatment between both groups p-value <0.05, and no significant differences after treatment in group 1 regarding these levels, p-value>0.05, but significant differences in the level of improvement after treatment between both groups and in group 2 were found, p-value <0.05.Conclusions: The severity of LUTS and psychological morbidity have a positive relationship and were higher in the pretreatment surgical group, but the effect of TURP was superior to the medical group in the management of this morbidity and its causative (LUTS).

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Section: Discussioncontrasting

confidence: 49%

Treatment of psychological morbidity secondary to benign prostatic hyperplasia: a comparative study

et al. 2020

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“…The score gives an idea of the severity of LUTS and the most bothersome symptoms. On follow-up, the score can give accurate documentation of patients' progression and deterioration [65].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Impact of Some Selected Plants on Haematological Parameters of Testosterone and Estradiol Induced Benign Prostatic Hyperplasia Adult Male Rats

Ugwu

Asuk

Eteng

et al. 2019

IBRR

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Background: Benign prostate hyperplasia (BPH) is an age-related disease of unknown etiology, characterized by prostate enlargement. The effect of Prosopis africana (PA), Vernonia amydalina (VA) and Ocimum gratissmum (OG), plant extracts on haematological parameters of BPH animal model was investigated. Methods: BPH was induced in 45 male Wistar rats (250-350 g) by exogenous injection of testosterone and estradiol in staggered doses for 3 weeks. To confirm BPH induction, some animals were sacrificed; histological inspection of prostate gland and PSA was carried out. Forty BPH induced rats were divided into 8 groups. Group 1 and 2, 3 and 4, 5 and 6 were treated with 50 mg/kg bw and 100 mg/kg bw doses of PA, VA and OG extracts respectively. Group 7 received finasteride (0.1 mg/kg bw). Group 8 BPH control and five rats without induction constitute group 9, the normal control and both received distilled water. After 45 days, the rats were anaesthetised by a brief exposure to trichloromethane vapour and 5 ml of blood was collected from the rats through cardiac puncture and dispensed into well-labelled EDTA containers to avoid coagulation. All analyses were completed within 24 h of sample collection. Results: Results showed that induction of BPH caused a significant (P< 0.05) enlargement of prostate gland when compared to normal control. All extracts produced significant (P<0.05) reduction in the weight of the enlarged prostate when compared to the BPH control. There were significant (P ˂0.05) decline in RBC, PCV and Hb of BPH control when compared to the normal control and treated groups. In the treated groups the administration of the extracts and standard drug exhibited an increase in RBC, PCV and Hb concentration when compared with the BPH control. Also there was significant (P < 0.05) increase in the WBC, neutrophils, platelets, monocytes, lymphocytes and eosinophils levels in BPH control when compared to normal control and treated groups. In all treated groups there was significant decrease in WBC, neutrophils, platelets, monocytes, lymphocytes and eosinophils concentration levels when compared with the BPH control group. Conclusion: The result of this study indicates that the extracts have the potential to reverse the inflammation caused by BPH and also have the capacity to boost the numbers of red blood cells probably by inhibiting the hemolysis caused by inflammatory factors or by enhancing the production of red blood cell from the bone marrow.

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“…BPH is a progressive disease with a frequency that successively increases mainly after the age of 50. [1][2][3][4][5][6] This study showed that patients aged 60 to 69 were predominant. Complications of BPH can occur immediately, but they can also occur after many years of the onset of the first symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, the obstruction itself (in this case caused by enlargement of the prostate) causes neural changes on the detrusor that further contribute to the formation and development of symptoms of clinical (symptomatic) BPH. [1][2][3][4][5][6] The aim of this study is to analyse the frequency of typical complications in the treatment of patients with benign prostatic hyperplasia and the effect of medicamentous treatment in groups patients with two different stages of BPH.…”

Section: Methodsmentioning

confidence: 99%

Frequency of common complications during treatment of patients with benign prostate hyperplasia

Krickovic¹,

Simatović²,

Lukić³

et al. 2020

Scripta Medica

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Background/Aim: Benign prostatic hyperplasia (BPH) is a very common disease in older men. BPH involves the presence of signs of hyperplasia of the stromal and epithelial elements in the prostate with consequent enlargement of its volume. The aim of this study is to analyse the frequency of typical complications in the treatment of patients with benign prostatic hyperplasia and the effect of medicamentous treatment. Method: Patients diagnosed BPH were included in the prospective, one-year study. They were divided into 2 groups. The first group (30 patients) consisted of those ones, whose prostate volume was equal to or over 50 cm 3 , while and the second group (30 patients) comprised the subjects with prostate volume less than 50 cm 3 . The complications of BHP analysed are residual urine (RU), symptomatic urinary infection, haematuria, thickening of the detrusor wall, diverticulum in the bladder, ureterohydronephrosis, renal failure, bladder stone and acute urinary retention (AUR). Results: The majority of patients in both groups were aged 60-69. There was a statistically significant difference in the average value of RU between the groups at the first, second and fifth check-ups (p < 0.05), as well as the complication of symptomatic urinary infection, since the same occurred earlier in the first group than in the second group (p < 0.05). There was no statistically significant difference in complications: haematuria, detrusor wall thickening and diverticulum (p > 0.05). Complications: ureterohydronephrosis, renal failure, bladder stone, and AUR were not diagnosed in patients in either group. Conclusion: Relevant medical therapy leads to a reduction of RU and reduces the risk of complications caused by its presence. Other complications of BPH were rare or absent in both groups, suggesting that appropriate and timely applied medical therapy affects the course of BPH and reduces the risk of complications and the need for surgical treatment. Benefit from medicamentous therapy is equally represented in both analysed groups of patients.

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Benign prostatic hyperplasia and male lower urinary symptoms: A guide for family physicians

Cited by 20 publications

References 3 publications

Treatment of psychological morbidity secondary to benign prostatic hyperplasia: a comparative study

Treatment of psychological morbidity secondary to benign prostatic hyperplasia: a comparative study

Evaluation of Impact of Some Selected Plants on Haematological Parameters of Testosterone and Estradiol Induced Benign Prostatic Hyperplasia Adult Male Rats

Frequency of common complications during treatment of patients with benign prostate hyperplasia

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