Benign Prostate Hyperplasia and Chronic Kidney Disease

Leão, Ricardo; Pereira, Bruno Jorge; Coelho, Hugo

doi:10.5772/25290

Cited by 4 publications

(2 citation statements)

References 115 publications

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“…Böbrek hasarı; erken ölüm, düşük yaşam kalitesi ve artan sağlık bakım harcamaları ile ilişkili ciddi bir durumdur. Tedavi edilmeyen böbrek hasarı, diyaliz veya böbrek nakli gerektiren son dönem böbrek hastalığına neden olabilmektedir (8).…”

Section: Introductionunclassified

Prostat Spesi̇fi̇k Anti̇jen Ve Böbrek Fonksi̇yon Testleri̇ Arasindaki̇ İli̇şki̇ni̇n Nedeni̇: Yaş

Vurgun¹

2023

Kocatepe Tıp Dergisi

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AMAÇ: İleri yaş erkeklerde sık görülmekte olan prostat ve böbrek hastalıklarının tarama, tanı ve tedavi takiplerinde kullanılmakta olan prostat spesifik antijen (PSA) ve kreatinin, tahmini glomerüler filtrasyon hızı (eGFR), üre ürik asit düzeyleri arasındaki ilişkilerin araştırılması amaçlandı. GEREÇ VE YÖNTEM: Eylül 2017 – Mart 2020 tarihleri arasında 40 yaş ve üzerindeki 7203 erişkin erkek hastaya ait eş zamanlı olarak istenmiş olan serum PSA, kreatinin, üre ve ürik asit sonuçları retrospektif olarak incelendi. Parametreler arasındaki korelasyonlar yaşın etkisi ile birlikte değerlendirildi. Ek olarak PSA yüksekliği ile eGFR azalışı arasındaki çift yönlü ilişki de incelendi. BULGULAR: Yaş değişkeni kontrol edildiğinde; PSA düzeyleri üzerine kreatinin, üre ve ürik asit düzeylerinin bir etkisi olmadığı (sırasıyla; p=0,63, p=0,28 ve p=0,39), benzer şekilde PSA düzeylerinin de kreatinin, üre ve ürik asit düzeyleri üzerine bir etkisi olmadığı gözlendi (sırasıyla; p=0,22, p=0,25 ve p=0,92). Yaş değişkeni ile birlikte yapılan regresyon analizlerinde; yaş arttıkça PSA yüksekliği görülme riski 1.09 kat artmakta iken kreatinin arttıkça ise riskin anlamlı bir değişim göstermediği tespit edildi (sırasıyla; p<0,001 ve p=0,99). Benzer şekilde yaş arttıkça orta ve ileri derecede eGFR azalış riski 1.11 kat artmakta iken PSA arttıkça ise riskin anlamlı bir değişim göstermediği tespit edildi (sırasıyla; p<0,001 ve p=0,31). SONUÇ: Çalışmanın bulguları ışığında; yaş arttıkça PSA ve kreatinin düzeylerinin yükselme riski artarken, yaş değişkeni kontrol edildiğinde PSA ve kreatinin düzeyleri arasındaki ilişkinin ortadan kalktığı ve yüksekliklerinin birbirleri üzerine etkisinin olmadığı sonucuna ulaşıldı.

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Section: Introductionunclassified

Prostat Spesi̇fi̇k Anti̇jen Ve Böbrek Fonksi̇yon Testleri̇ Arasindaki̇ İli̇şki̇ni̇n Nedeni̇: Yaş

Vurgun¹

2023

Kocatepe Tıp Dergisi

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“…However, the presentation of benign and malignant diseases can overlap especially when there are associated complications. This makes for instance a benign prostatic disease with associated uraemia manifesting features that may suggest malignant diseases such as constitutional symptoms including anorexia, weight loss, or body weakness as seen in malignant prostatic disease (8,9). This can be attributed to delayed presentations, a consequence of poor socioeconomic status and absence of universal health insurance coverage.…”

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confidence: 99%

Clinical Presentation of Prostatic Disease Patients in a Hospital Setting

Khalid¹,

Arzika²,

Peter³

et al. 2022

ABMS

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Background: Prostatic diseases are common urological conditions confronted by the urologist regularly. The clinical presentations may oftentimes be straightforward but at times challenging due to delayed patients' presentation in our setting, occasional overlap of symptoms and signs or when complications associated with the disease supervene. This study determines the difference in clinical presentations of patients histologically diagnosed with prostatic diseases among urology patients in our clinical setting. Materials and Methods: A prospective cross-sectional study conducted among 50 urology patients with indication for Transrectal ultrasound (TRUS) guided prostate biopsy at Usmanu Danfodiyo University Teaching Hospital, Sokoto, North-western, Nigeria. Data collected into a semistructured questionnaire and studied included: sociodemographic parameters, clinical symptoms and signs at presentation, International prostate symptoms score (IPSS), co-morbidities, Digital rectal examination (DRE), and histological findings. Results were analyzed using the computer software, IBM statistical package for the social sciences (SPSS) version 25 (SPSS Inc; Chicago, IL, USA). Relationships between variables were determined using Pearson's chi-square test, and Fisher's exact tests as appropriate. Results: A total of 50 patients were enrolled over the study period with a mean age of 67.32 ± 9.11 years and a range of 50-96 years. Thirty (60.0%) patients had benign prostatic hyperplasia (BPH) while 20 (40.0%) patients had prostatic adenocarcinoma (PCa). One (3.3%) patient with BPH had associated features of chronic prostatitis. The clinical presentations found to be statistically significant in favour of prostatic adenocarcinoma were weight loss, body weakness, cachexia, pallor, and abnormal digital rectal examination. Conclusion: The presence of weight loss, body weakness, cachexia, clinical pallor, and suspicious digital rectal examination at presentation are significant findings to raise a high index of suspicion of the prostate carcinoma. Hence, physicians and urologists coming in contact with prostatic disease patients should be well guided by this in our environment. Keywords: Clinical presentations, prostatic diseases, prostatitis, benign prostatic hyperplasia, prostatic adenocarcinoma

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Renal Papillary Necrosis (RPN) in an African Population: Disease Patterns, Relevant Pathways, and Management

et al. 2022

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Renal papillary necrosis (RPN) is characterized by coagulative necrosis of the renal medullary pyramids and papillae. Multiple conditions and toxins are associated with RPN. Several RPN risk factors, or POSTCARDS, have been identified, with most patients presenting with RPN having at least two contributing risk factors. Currently, there is no specific test to diagnose and confirm RPN; however, several imaging tools can be used to diagnose the condition. RPN is currently underdiagnosed in African populations, often with fatal outcomes. In African clinical settings, there is a lack of consensus on how to define and describe RPN in terms of kidney anatomy, pathology, endourology, epidemiology, the identification of African-specific risk factors, the contribution of oxidative stress, and lastly an algorithm for managing the condition. Several risk factors are unique to African populations including population-specific genetic factors, iatrogenic factors, viral infections, antimicrobial therapy, schistosomiasis, substance abuse, and hypertension (GIVASSH). Oxidative stress is central to both GIVASSH and POSTCARDS-associated risk factors. In this review, we present information specific to African populations that can be used to establish an updated consensual definition and practical grading system for radiologists, urologists, nephrologists, nuclear physicians, and pathologists in African clinical settings.

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Benign Prostate Hyperplasia and Chronic Kidney Disease

Cited by 4 publications

References 115 publications

Prostat Spesi̇fi̇k Anti̇jen Ve Böbrek Fonksi̇yon Testleri̇ Arasindaki̇ İli̇şki̇ni̇n Nedeni̇: Yaş

Prostat Spesi̇fi̇k Anti̇jen Ve Böbrek Fonksi̇yon Testleri̇ Arasindaki̇ İli̇şki̇ni̇n Nedeni̇: Yaş

Clinical Presentation of Prostatic Disease Patients in a Hospital Setting

Renal Papillary Necrosis (RPN) in an African Population: Disease Patterns, Relevant Pathways, and Management

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