Benign ovarian teratomas: a population-based case-control study

Westhoff, Carolyn; Pike, M. C.; Vessey, M. P.

doi:10.1038/bjc.1988.171

Cited by 59 publications

(36 citation statements)

References 22 publications

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“…No In this study, higher education was associated with an increased risk of benign ovarian teratomas. Similar evidence emerged from a previous population-based case-control study (Westhoff et al, 1988). It is difficult to interpret these findings, but diagnostic bias should be considered, since higher education or social class is a common characteristic of women with a diagnosis of benign gynecological conditions, such as seromucinous ovanan cysts (Parazzini et al, 1989), uterine fibroids (Paramni et al, 1988) or benign breast disease (Parazzini et al, 1984).…”

supporting

confidence: 52%

“…

(Simon et al, 1985;Westhoff et al, 1988). Epidemiological data on the issue, however, are scanty.

We report the results of a cas-control study on risk factors for benign ovarian teratomas conducted in the framework of a larger study on risk factors for benign and malignant ovarian diseases (Paramni et al, 1989;1991a

…”

mentioning

confidence: 99%

“…Most teratomas are benign and their peak incidence is around the third and fourth decades of life (Bennington et al, 1968;Vessey et al, 1987;Westhoff et al, 1988;Disaia and Creasman, 1989). Higher eduction, nulliparity, infertility, irregular menses, family history and alcohol consumption have been associated with an increased risk of benign ovarian teratomas (Simon et al, 1985;Westhoff et al, 1988). Epidemiological data on the issue, however, are scanty.…”

mentioning

confidence: 99%

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Risk factors for benign ovarian teratomas

Parazzini

Vecchia²,

Negri³

et al. 1995

Br J Cancer

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supporting

confidence: 52%

“…

(Simon et al, 1985;Westhoff et al, 1988). Epidemiological data on the issue, however, are scanty.

…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Risk factors for benign ovarian teratomas

Parazzini

Vecchia²,

Negri³

et al. 1995

Br J Cancer

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“…It has been suggested that the aetiology of germ cell tumours in women is similar to that of testicular germ cell cancer (Walker et al, 1984;Henderson et al, 1988;Walker et al, 1988;Westhoff et al, 1988;dos Santos Silva and Swerdlow, 1991). Thus, oestrogen exposure may represent an initiation role in utero, and gonadotropins may have a promoting effect in early adulthood Walker et al, 1988;dos Santos Silva and Swerdlow, 1991).…”

Section: Discussionmentioning

confidence: 99%

Full-term pregnancies and incidence of ovarian cancer of stromal and germ cell origin: a Norwegian prospective study

Albrektsen

Heuch²,

Kvåle³

1997

Br J Cancer

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Summary Associations between the incidence of stromal and germ cell ovarian cancer and pregnancies were examined in a follow-up of 1.1 million women aged 20-56 years. Stromal tumours (41 cases) showed no clear associations. Germ cell tumours (71 cases) were related to high-age childbirths and short time since birth.Keywords: stromal tumour; germ cell tumour; parity; population-based study; prospective study (Cramer and Welch, 1983), but few studies have compared the two cancer types. Furthermore, it has been suggested that exposure to oestrogens in utero may be a risk factor for ovarian cancer of germ cell origin Walker et al, 1988). If endogenous female sex hormones play a role in the aetiology of germ cell tumours, the very high levels of such hormones during pregnancy might also influence the risk of germ cell tumours for the mother.The aim of the present study was to investigate the potential relations between the incidence of ovarian cancer of stromal and germ cell origin and the number of full-term pregnancies, age at first and last birth and time since last birth in a large cohort of Norwegian women. We have previously reported on relations between the risk of epithelial ovarian cancer and reproductive factors in the same data set (Albrektsen et al, 1996). MATERIALS AND METHODSThe present study includes all Norwegian women born in the period 1935 (Serov et al, 1973) as germ cell tumours (35 dysgerminomas, 25 malignant teratomas, nine embryonal carcinomas, two choriocarcinomas) and 41 cases as sex cord/stromal tumours (23 granolusa-stromal cell tumours, eight androblastomas, one Sertoli cell tumour, nine sarcomas). Separate analyses were performed for sex cord/stromal tumours (referred to as stromal tumours) and germ cell tumours. Statistical analysesPotential relations between the risk of ovarian cancer of stromal and germ cell origin and reproductive factors were examined in a log-linear Poisson regression model of person-years at risk (Breslow and Day, 1987). In this context, a woman was considered to be at risk of developing ovarian cancer from the age of 20 years. Certain analyses included parous women only. Date of each delivery was recorded, and a woman contributed person-years in successive categories of attained age, number of full-term pregnancies, age at last birth and time since last birth. A woman was withdrawn from follow-up at the date of ovarian cancer diagnosis, emigration or death. Women with a diagnosis of ovarian cancer different from the histological classification under consideration (including epithelial ovarian cancer) were withdrawn at date of diagnosis.All analyses were adjusted for attained age in 1-year intervals and birth cohort in 5-year intervals. In the statistical model, 767

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“…But at times benign cystic teratoma may appear to be suspiciously malignant during initial scan due to its complex solid and cystic nature [16][17][18][19] . The malignant degeneration may be present in one to three percent of all cystic teratomas [16][17][18][19][20][21][22][23][24][25][26] . Computed Tomography (CT) scan, specifi cally diagnoses fat, calcifi cations and fat level correctly and is considered the modality of choice.…”

Section: Bodymentioning

confidence: 99%

The value of ultra sonogram in the diagnosis of ovarian dermoid cysts

Pradhan

2014

J. Kathmandu Med. Coll.

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Mature cystic teratoma often referred to as dermoid cysts have been diagnosed using all imaging modalities. Dermoid cysts present various and complex ultrasonographic aspects. At times diagnosis may be diffi cult and lead to confusion due to its complex solid and cystic nature. The specifi city for diagnosis of fat and calcifi cation makes computed tomography (CT) scan the modality of choice. But CT scan is high technique equipment, expensive and may not be affordable or available at all places. Advances in the quality of USG machines, better experiences of ultrasound operators and thorough analysis of all ultrasound features that characterise dermoid cysts have resulted in an increased accuracy of exact ultrasonographic diagnosis of dermoid cysts in the vast majority of the cases and now used as the fi rst preoperative work-up method of choice for the assessment of adnexal masses in clinical practices.

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Benign ovarian teratomas: a population-based case-control study

Cited by 59 publications

References 22 publications

Risk factors for benign ovarian teratomas

Risk factors for benign ovarian teratomas

Full-term pregnancies and incidence of ovarian cancer of stromal and germ cell origin: a Norwegian prospective study

The value of ultra sonogram in the diagnosis of ovarian dermoid cysts

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