Benign mucocele-like lesions of the breast: revisited

Jaffer, Shabnam; Bleiweiss, Ira J.; Nagi, Chandandeep

doi:10.1038/modpathol.2010.235

Cited by 35 publications

(25 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of reports have subsequently described an association between MLL and the simultaneous presence of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and/or mucinous carcinomas[3–8]. The frequency of ADH associated with MLL reported in the literature ranges from 11–57%, and that of DCIS from 2–30%[3–8].…”

Section: 1 Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases

et al. 2016

View full text Add to dashboard Cite

Mucocele-like lesions (MLL) of the breast are characterized by cystic architecture with stromal mucin and frequent atypia, but it is unknown whether they convey long term breast cancer risk. We evaluated 102MLL that were derived from a single institution benign breast disease (BBD) cohort of 13412 women who underwent biopsy from 1967–2001.MLL were histologically characterized by type of lining epithelium, architecture of the lesion, associated atypical hyperplasia (AH) and for incidence of breast cancer (14.8 years median follow-up). A relatively large proportion of MLL (42%) were diagnosed in women >55 years of age AH was significantly more frequent in MML patient compared to the cohort overall (27% vs 5%, p<0.001). Breast cancer has developed in 13 patients with MLL.. This frequency is only slightly higher than population expected rates overall (Standardized incidence ratio (SIR) 2.28, 95% CI 1.21–3.91), and not significantly different from women in the cohort with (non atypical) proliferative breast lesions. Younger women (<45) with MLL had a non-significant increase in risk of cancer compared to the general population (SIR 5.16, 95% CI 1.41–13.23). We conclude MLL is an uncommon breast lesion that is often associated with co-existing AH. However, in women over age 45, MLL do not convey additional risk of breast cancer beyond that associated with the presence of proliferative disease.

show abstract

Section: 1 Introductionmentioning

confidence: 99%

“…The frequency of ADH associated with MLL reported in the literature ranges from 11–57%, and that of DCIS from 2–30%[3–8]. This finding has prompted some to consider MLL as a precursor to breast cancer.…”

Section: 1 Introductionmentioning

confidence: 99%

Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases

et al. 2016

View full text Add to dashboard Cite

show abstract

“…All patients in the initial report were benign, except one who had a separate unrelated non‐mucinous intraductal carcinoma (DCIS), and they remained well after a follow‐up of 6–88 months. Subsequent studies showed that MLL could be associated with atypical ductal hyperplasia (ADH), DCIS or mucinous carcinoma . The frequency of malignancy after a diagnosis of MLL without atypia on core biopsy reported in the literature shows a wide range, due mainly to the small number of patients, with only one series having more than 10 patients …”

Section: Introductionmentioning

confidence: 99%

Outcome of pure mucocele‐like lesions diagnosed on breast core biopsy

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Indeed some advocate diagnostic excision in these cases. 15,16 In the majority of cases, lesser disease ranging from columnar cell change up to DCIS is found. 17 In the case illustrated here, a diagnostic excision was performed which showed mostly further mucocele-like lesion.…”

Section: Answermentioning

confidence: 99%