Benign metastasizing leiomyoma: A cytogenetically balanced but clonal disease

Tietze, L.; Günther, Kalle; Hörbe, Alexandra; Pawlik, Christine; Klosterhalfen, B.; Handt, Stefan; Merkelbach‐Bruse, Sabine

doi:10.1016/s0046-8177(00)80210-5

Cited by 116 publications

(83 citation statements)

References 8 publications

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“…Patient 3 also demonstrated an identical X-chromosome inactivation pattern (Figure 5c). From our findings and those of others, 5 we draw the following conclusions: benign metastasizing leiomyoma is a neoplastic process; lung leiomyomas are clonally related to uterine leiomyomas; and benign metastasizing leiomyoma is different from primary pulmonary leiomyomatosis.…”

Section: Discussionsupporting

confidence: 75%

“…First, like the subjects in our study, all the patients so far described are females of late reproductive age (Table 2) with a history of, or coexisting, uterine leiomyomas. Next, morphological, immunohistochemical, and molecular analyses in this and another report 5 demonstrate that the lung tumors and uterine tumors are identical in their morphology, immunohistochemical features, and clonal origin. Although multifocality is a remote possibility, 4 with the exception of a couple of case reports (Table 2), 2,4 coexisting leiomyomas in gastrointestinal tract, skin or other organs have not been reported in these patients.…”

Section: Discussionsupporting

confidence: 49%

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Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis

et al. 2006

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Benign metastasizing leiomyoma is a rare condition affecting women with a history of uterine leiomyomata and is characterized by multiple histologically benign pulmonary smooth muscle tumors. Speculations on its pathogenesis include a benign uterine leiomyoma colonizing the lung, a metastatic low-grade uterine leiomyosarcoma, and primary pulmonary leiomyomatosis. To elucidate its pathogenesis, we analyzed the clinical, pathological and immunohistochemical features, clonality, and telomere length of multiple lung and uterine tumors in three patients with benign metastasizing leiomyoma. In all cases, pulmonary tumors had benign histology and immunohistochemical profiles (estrogen receptor positive, progesterone receptor positive, and very low proliferative index) identical to uterine leiomyoma. In eight tumors from three patients, clonality was assessed by analyzing the variable length of the polymorphic CAG repeat sequence within the human androgen receptor gene. In the two informative patients pulmonary and uterine tumors showed identical patterns of androgen receptor allelic inactivation, indicating that they were clonal. The telomere length measured by fluorescence in situ hybridization in pulmonary leiomyomas of all three patients were either long or very long and were identical to the uterine counterparts, indicating significant telomere shortening is not a crucial step for developing metastases. Our evidence supports the notion that benign metastasizing leiomyoma is clonally derived from benign-appearing uterine leiomyomas.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 49%

Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis

et al. 2006

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“…2,7) Optimal therapy for BML has not been established, but the treatment option of choice is a primary surgical resection of the tumor masses. 8) If lesions are not resectable, hormone treatment should be considered instead.…”

Section: Discussionmentioning

confidence: 99%

“…1,2) Although these lesions are slow-growing and asymptomatic and are usually incidentally diagnosed, they may cause debilitating symptoms and even life-threatening complications. 3,4) The small number of cases described in the literature and uncertainties regarding the optimal treatment and progression of the condition have promoted the publication of new reports.…”

Section: Introductionmentioning

confidence: 99%

Benign Metastasizing Leiomyoma of the Lung

Goto

Maeshima

Akanabe

et al. 2012

Ann Thorac Cardiovasc Surg

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A 44-year-old woman was found to have an abnormal shadow on a chest X-ray during a regular health checkup, and visited our department. Chest computed tomography showed multiple nodular shadows in both lungs. The patient had no history of neoplasm except for myomectomy for uterine leiomyoma 6 years previously. Eighteen months later, the nodules showed a gradual increase in size, and video-assisted thoracoscopic biopsy of a nodule was performed. Histopathologically, the pulmonary nodule was composed of benign smooth muscle cells proliferating in fascicles, consistent with the diagnosis of benign metastasizing leiomyoma. Benign metastasizing leiomyoma is defined as a histologically benign uterine smooth muscle tumor that acts in a somewhat malignant fashion and produces benign metastases. Although it is a rare condition, it should be considered in asymptomatic women of reproductive age with a history of uterine leiomyoma, who present with solitary or multiple pulmonary nodules. Herein, we report a case of pulmonary benign metastasizing leiomyoma.

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“…In such cases, morphological traits allow the reliable prediction of clinical behaviour. In other cases, however, correlation of morphological patterns with clinical prognosis remains a significant challenge [27,28].…”

Section: Caspasementioning

confidence: 99%

Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

Plewka¹,

Plewka²,

Madej³

et al. 2011

Folia Histochem Cytobiol.

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P P P P Processes of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in uterine myomas originating from uterine myomas originating from uterine myomas originating from uterine myomas originating from uterine myomas originating from reproductive and perimenopausal women reproductive and perimenopausal women reproductive and perimenopausal women reproductive and perimenopausal women reproductive and perimenopausal women We studied uterine myomas originating from females of reproductive age and from females of perimenopausal age. Uterine myomas represent benign tumors of the myometrium, and they develop frequently in women of reproductive age. The frequency of uterine myomas increases with age until women reach the menopause. The study included patients with a myomatous uterus, in the reproductive age or peri-menopausal age, independently evaluating small and large myomas. Myometrial alterations in their direct vicinity were evaluated independently of the myomas. The study included evaluation of immunolocalization of two index proteins which participate in myoma cells growth control: Ki-67 nuclear antigen and caspase 3. In women of reproductive age, both in small and large myomas, elevated immunostaining of Ki-67 was noted in parallel to low levels of caspase 3 staining, which indicated the ongoing process of proliferation. In women of peri-menopausal age with small or large myomas, no Ki-67 immunostaining was detected, while staining of caspase 3 manifested low levels. Proliferation in reproductive age women myomas is higher than in the peri-menopausal age. (Folia Histochemica et

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Benign metastasizing leiomyoma: A cytogenetically balanced but clonal disease

Cited by 116 publications

References 8 publications

Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis

Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis

Benign Metastasizing Leiomyoma of the Lung

Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

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