Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

Abstract

P P P P Processes of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in rocesses of apoptosis and cell proliferation in uterine myomas originating from uterine myomas originating from uterine myomas originating from uterine myomas originating from uterine myomas originating from reproductive and perimenopausal women reproductive and perimenopausal women reproductive and perimenopausal women reproductive and perimenopausal women reproductive and perimenopausal women We studied uterine myomas originating from females of reproductive age and from females of perimenopausal age. Uterine myomas represent benign tumors of the myometrium, and they develop frequently in women of reproductive age. The frequency of uterine myomas increases with age until women reach the menopause. The study included patients with a myomatous uterus, in the reproductive age or peri-menopausal age, independently evaluating small and large myomas. Myometrial alterations in their direct vicinity were evaluated independently of the myomas. The study included evaluation of immunolocalization of two index proteins which participate in myoma cells growth control: Ki-67 nuclear antigen and caspase 3. In women of reproductive age, both in small and large myomas, elevated immunostaining of Ki-67 was noted in parallel to low levels of caspase 3 staining, which indicated the ongoing process of proliferation. In women of peri-menopausal age with small or large myomas, no Ki-67 immunostaining was detected, while staining of caspase 3 manifested low levels. Proliferation in reproductive age women myomas is higher than in the peri-menopausal age. (Folia Histochemica et

The molecular mechanisms and morphological manifestations of leiomyoma reduction induced by selective progesterone receptor modulators

“…Основным маркером для оценки пролиферативной активности клеток является ядерный антиген Ki-67 [27]. Определение его уровня экспрессии позволяет выделить клетки, находящиеся в активной фазе клеточного цикла на всем его протяжении [28].…”

Use of Chinese Medicine and Subsequent Surgery in Women with Uterine Fibroid: A Retrospective Cohort Study

“…They are the leading indication for hysterectomy all over the world and are associated with a substantial economic impact on health care systems, including associated costs of $4–9 billion per year in the United States alone [2]. These tumors grow frequently in women of reproductive age, regressing after menopause [3], and can cause various symptoms including infertility, pregnancy complications [4], pelvic pain [5], and abnormal or heavy bleeding that can lead to anemia [6]. …”

“…Surgery is an invasive treatment that can cause even more severe complications than a fibroid itself. Potential short-term complications of surgery include febrile morbidity, blood loss, and organ injuries [9], while possible long-term complications, such as fistula formation, adhesion, and sexual dysfunctions [10], can last for many years, even beyond menopause, when a uterine leiomyoma is no longer a threat to health [3]. Consequently, alternative treatments to surgery for the management of fibroid-related symptoms have been sought and evaluated for years to minimize surgery in patients [11].…”

The influence of the expression of steroid receptors on angiogenesis, proliferation and apoptosis in myomas of pre- and postmenopausal women

“…The key pathological processes involved in myoma growth are proliferation and hypertrophy of leiomyocytes, apoptosis, angiogenesis, stromal and secondary changes [6]. The most reliable marker of cell proliferation is Ki-67 or a proliferation-cell nuclear antigen, which denotes not only the cells in the divide, but also DOI: https://doi.org/10.2298/SARH181030023M all those in the synthetic phase of the cell cycle [7]. A high level of Ki-67 antigen, detected during the secretory phase, suggests that progesterone has a synergistic effect in the pathogenesis of myoma [8].…”