Benign Lymphoid Hyperplasia of the Conjunctiva in Children

Abstract

enign lymphoid hyperplasia of the conjunctiva occurs infrequently in children, and its presentation, clinical course, and appropriate management are not well established. We describe 2 children with nasal conjunctival masses that on pathological examination demonstrated benign lymphoid hyperplasia. Local irradiation of residual tissue was deferred, and the lesions remained stable for 1 year in one case and for 3 1 ⁄2 years in the other case. No systemic involvement had occurred. Although the natural history of extranodal lymphoid hyperplasia in children is poorly documented, most cases of nodal lymphoid hyperplasia in children are at very low risk of malignant transformation. Careful observation for local and systemic disease is indicated for ocular adnexal lymphoid hyperplasia in children until a more complete understanding of its natural history is available.

Conjunctival tumors in children

“…Lymphoid tumors can occur in the conjunctiva as isolated lesions or they can be a manifestation of systemic lymphoma [44][45][46][47][48][49][50]. This condition is most often found in older adults and rarely in children.…”

Immunoglobulin Heavy Chain Gene Rearrangement Studies in the Diagnosis of a Paediatric Conjunctival Lesion

“…The use of steroid eye drops could have potentially masked the characteristics of the lesion, hence further confounding diagnosis. [3] Contamination or incorrect processing of the biopsy during initial histopathology and flow cytometry can produce inaccurate findings [5]. Since the proper methodology was conducted correctly for this case, this is unlikely.…”

“…Since the proper methodology was conducted correctly for this case, this is unlikely. Eventual diagnosis of BRLH is reassuring given the very low risk of malignant transformation in children [3]. …”

“…From the recommended 1-month follow-up, the patient displayed no extra-ocular manifestations of lymphoma on physical examination [3]. A chest X-ray and serological investigations were also conducted with no abnormalities detected.…”

Benign reactive lymphoid hyperplasia of the conjunctiva in childhood

“…The pathogenesis, pathological, IHC features and clinical course of the condition have not been extensively studied 5 18. In this study, we present a cohort of 24 cases with detailed clinical information, histomorphological and immunohistochemical examination, with additional molecular testing, giving us the opportunity to better understand the clinical and histopathological features of BRLH in children and study the clinical outcomes of this disease.…”