Benign cephalic histiocytosis: a case report

Godfrey, Keith M.; James, M.P.

doi:10.1111/j.1365-2133.1990.tb01854.x

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…They are usually classified either as Langerhans' cell histiocytosis (LCH) or non-LCH, based on the pathology of the proliferating histiocytes (1). Among the main types of non-LCH are benign cephalic histiocytosis, mononuclear (early) juvenile xanthogranuloma, xanthoma disseminatum, and generalized eruptive histiocytomas (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Benign cephalic histiocytosis is rare in young children, heals spontaneously, and has not been associated with internal involvement in the 35 cases reported to date (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”

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Benign Cephalic Histiocytosis with Diabetes Insipidus

Weston

Travers

Mierau

et al. 2000

Pediatric Dermatology

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Benign cephalic histiocytosis is a rare skin condition consisting of small tan papules on the face and upper trunk that is believed not to be associated with internal organ involvement. The infiltrating histiocytes are not Langerhans' cells (LCs). We report a 5-year-old girl who presented with diabetes insipidus 1 year after developing multiple small brown asymptomatic skin papules. Histologic examination revealed a non-LC histiocytic proliferation in the dermis without epidermal invasion. She had infiltration of the pituitary stalk on brain imaging. Diabetes insipidus has heretofore been associated with LC histiocytosis and xanthoma disseminatum but not benign cephalic histiocytosis.

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Benign Cephalic Histiocytosis with Diabetes Insipidus

Weston

Travers

Mierau

et al. 2000

Pediatric Dermatology

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“…Benign cephalic histiocytosis (BCH) was described in 197i by Gianotti et al (1), who used the term "histiocytosis with intracytoplasmic wormlike particles." Since then about 20 cases have been published (2)(3)(4)(5)(6)(7)(8)(9)(10). The disease is benign and selflimiting, and is included in the non-X (11,12), nonlipid (4) group of histiocytoses.…”

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Benign Cephalic Histiocytosis: Case Report and Literature Review

Peña-Penabad¹,

Unamuno²,

García-Silva³

et al. 1994

Pediatric Dermatology

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A 3-year-old boy had maculopapules on his face and neck since age 6 months. These were yellow-brown, asymptomatic, and clinically similar to flat warts. Histopathologic study revealed a fibrohistiocytic infiltrate in the superficial dermis. Ultrastructurally, comma-shaped bodies, desmosome-like junctions, and coated vesicles were seen; there were no lipid droplets or Birbeck granules. With these data, a diagnosis of benign cephalic histiocytosis was made. Twenty-five cases are reported in the literature: 17 males and 8 females (male:female ratio 2:1). Sixteen patients had lesions on parts of the body other than the head, neck, and shoulders.

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“…In a blinded histological study BCH, GEH and early non-xanthomatous JXG did not show significant differences (9). BCH may be differentiated from JXG by the absence of foamy cells and Touton giant cells (10). In contrast, Langerhans cell histiocytoses show reniform nuclei, eosinophil cytoplasm and epidermotropism, which were absent in our patient.…”

Section: Acta Dermato-venereologicamentioning

confidence: 48%