Benign and Malignant Neoplasms, Meninges, Rat

Mitsumori, Kunitoshi; Stefanski, Steven A.; Maronpot, Robert R.

doi:10.1007/978-3-642-83516-2_20

Cited by 10 publications

(15 citation statements)

References 19 publications

(15 reference statements)

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“…Granular cell tumors are the most common lung tumors in the horse, are not uncommon in the meninges and brain of the rat, and have been reported in the tongue of dogs. 12,17,22 Regardless of species and anatomic location, the majority of these tumors apparently have a homogeneous light microscopic appearance and a benign clinical course. 15,17,21 Malignancy was associated with local recurrence in a cat and recurrence or metastasis in humans.…”

Section: Discussionmentioning

confidence: 99%

“…16 None of the rat tumors whose ultrastructural features have been published, including those of the present report, contained basal lamina, regardless of whether they were meningeal or from the female reproductive tract. 4,12 Human granular cell tumors have been characterized in more detail immunohistochemically than have those of animals. Most human and animal granular cell tumors display immunoreactivity to S100.…”

Section: Discussionmentioning

confidence: 99%

“…In dogs, granular cell tumors most frequently occur in the oral cavity, in horses in the lungs, and in rats in the meninges and brain. 9,12,17,19,22 Granular cell tumors of the rodent reproductive tract have been primarily reported in mice following treatments with estrogens. 7,8 Single cases of spontaneous cervical or vaginal granular cell tumors have been reported in rats.…”

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confidence: 99%

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Granular Cell Lesions in the Distal Female Reproductive Tract of Aged Sprague-Dawley Rats

Markovits

Sahota

2000

Vet Pathol

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Abstract. During the review of a rat carcinogenicity study, a spectrum of granular cell lesions was recognized in the distal female reproductive tract. To verify the diagnoses, cell populations of nine granular cell alterations of the cervix or vagina were characterized immunohistochemically and four were evaluated ultrastructurally. Immunoreactivity was demonstrated in 8/9 cases with S100 protein, 6/9 cases with neuron-specific enolase, and 7/9 cases with Leu-7. Granular cells were negative for smooth muscle-specific actin and calretinin. The immunohistochemical profile of these lesions was similar to that previously reported in other species, including humans. Ultrastructurally, as expected many lysosomal bodies were present in the cytoplasm of granular cells in all specimens evaluated. Based on the detailed evaluation of a series of lesions, we adopted the following diagnostic criteria and nomenclature for the granular cell changes of the female reproductive tract of rats. Granular cell aggregates were non-space-occupying lesions composed of clusters of typical granular cells. Benign granular cell tumors were space occupying lesions that typically contained prominent interstitial collagen and were either discrete masses or were difficult to discern from the surrounding tissues. Some benign tumors also contained foci of spindle cells with decreased granularity. Malignant tumors exhibited pleomorphism and an increased nucleus : cytoplasm ratio morphologically but had the same biologic behavior as the benign tumors. We applied these diagnostic criteria during the review of controls from 9 carcinogenicity studies. Up to 23% of control females in those carcinogenicity studies had granular cell lesions that could be classified into one of the three categories. Granular cell lesions appear to be common in the cervix/vagina of the SpragueDawley rat, and tumors may develop from granular cell aggregates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Granular Cell Lesions in the Distal Female Reproductive Tract of Aged Sprague-Dawley Rats

Markovits

Sahota

2000

Vet Pathol

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“…Granular cell tumors are rare tumors that occur in a wide range of species in different anatomic locations, including the cervix and vagina of rats (1,5,7). Until recently, spontaneously occurring granular cell tumors in the rat female reproductive tract were case reports of often a single tumor.…”

Section: Introductionmentioning

confidence: 99%

Aromatase Inhibitors Prevent Spontaneous Granular Cell Tumors in the Distal Female Reproductive Tract of Sprague-Dawley Rats

Markovits

Sahota

2000

Toxicol Pathol

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We recently established diagnostic criteria for granular cell changes in the distal female reproductive tract of rats. In a review of control animals from 9 carcinogenicity studies, we found that approximately 23% of animals had granular cell alterations. Because estrogen may play a role in the pathogenesis of granular cell alterations, we reviewed tissue sections from carcinogenicity studies with 2 aromatase inhibitors and found compound-related decreases in the incidence of granular cell changes. Since these aromatase inhibitors selectively prevent the conversion of androgenic steroids to the corresponding estrogens, these data further suggest that estrogen may play a role in the pathogenesis of granular cell tumors of the reproductive tract of rats.

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“…In laboratory animals, it is well-known that GCT frequently occurs in the meninges and the female genital tract in aged rats 2,3,4 , although no case has been reported in laboratory beagles. Canine GCTs arise mostly in the oral cavity such as gingiva, lip, and tongue at about 10 years of age [5][6][7] , and there have also been cases reported in the skin 5,8 , meninges 7,9 , heart 10 , lymph nodes 9 , brain 11,12 , pituitary gland 13 , and pleural surface 14 .…”

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Spontaneous Granular Cell Tumor of Cecum in a Laboratory Beagle

et al. 2003

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A spontaneous granular cell tumor was found in the cecum of a 9-month-old female beagle. The tumor cells were distributed widely and multifocally throughout the cecal submucosa and basal portion of the lamina propria, but never formed macroscopic nodular lesions. Partial infiltration into the muscular layer was observed, but neither metastasis nor invasion to other tissues was detected. The tumor cells were oval to polygonal and were characterized by abundant eosinophilic and PAS positive granules in the cytoplasm. Immunohistochemically, the tumor cells were positive for vimentin, but negative for S-100 protein, NSE, desmin, lysozyme, and α1-antichymotripsin.Ultrastructurally, various numbers of lysosomal bodies containing lamellar and membranous structures were present in the cytoplasm. Neither basal lamina nor cell-to-cell communications were observed. This is the first report of canine granular cell tumor arising in the cecum and is of interest as it occurred in a young laboratory beagle. (J Toxicol Pathol 2003; 16: 275-278)

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Benign and Malignant Neoplasms, Meninges, Rat

Cited by 10 publications

References 19 publications

Granular Cell Lesions in the Distal Female Reproductive Tract of Aged Sprague-Dawley Rats

Granular Cell Lesions in the Distal Female Reproductive Tract of Aged Sprague-Dawley Rats

Aromatase Inhibitors Prevent Spontaneous Granular Cell Tumors in the Distal Female Reproductive Tract of Sprague-Dawley Rats

Spontaneous Granular Cell Tumor of Cecum in a Laboratory Beagle

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