Aromatase Inhibitors Prevent Spontaneous Granular Cell Tumors in the Distal Female Reproductive Tract of Sprague-Dawley Rats

Markovits, Judith; Sahota, Pritam S.

doi:10.1177/019262330002800605

Cited by 7 publications

(6 citation statements)

References 10 publications

(16 reference statements)

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“…However, on histological examination immunoperoxidase staining failed to reveal an estrogen receptor. 6 In 2000, Markovits and Sahota 17 reported a decreased incidence of granular cell tumors of the reproductive tract in rats treated with aromatase inhibitors, which decrease circulating estrogen levels. Furthermore, the probable recurrence with each pregnancy in our case report, along with the predominance of female patients with GCT, suggests that hormonal factors may indeed be involved.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Tumor of the Trachea in Pregnancy: A Case Report and Review of Literature

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Granular Cell Tumor of the Trachea in Pregnancy: A Case Report and Review of Literature

et al. 2004

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“… 29 Courtney et al (1992), 78 Hollander et al (1976), 102 Krinke et al (1985), 103 Krinke et al. (2000), 123 Markovits and Sahota (2000a), 124 Markovits and Sahota (2000b), 200 Veit et al (2008), 92 Kaufmann et al (2012)…”

Section: Morphologymentioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…The model provided evidence to show that aromatase overexpression is sufficient to induce and maintain early preneoplastic and neoplastic changes that can be completely abrogated by treatment with letrozole. Carcinogenicity studies have also found that letrozole decreases the incidence of spontaneous mammary tumors and granular cell tumors in rats [ 104 ].…”

Section: Letrozole Pharmacodynamics and Pharmacokineticsmentioning

confidence: 99%

The discovery and mechanism of action of letrozole

Bhatnagar

2007

Breast Cancer Res Treat

167

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Because estrogen contributes to the promotion and progression of breast cancer, a greater understanding of the role of estrogen in breast cancer has led to therapeutic strategies targeting estrogen synthesis, the estrogen receptor, and intracellular signaling pathways. The enzyme aromatase catalyses the final step in estrogen biosynthesis and was identified as an attractive target for selective inhibition. Modern third-generation aromatase inhibitors (AIs) effectively block the production of estrogen without exerting effects on other steroidogenic pathways. The discovery of letrozole (Femara 1 ) achieved the goal of discovering a highly potent and totally selective AI. Letrozole has greater potency than other AIs, including anastrozole, exemestane, formestane, and aminoglutethimide. Moreover, letrozole produces near complete inhibition of aromatase in peripheral tissues and is associated with greater suppression of estrogen than is achieved with other AIs. The potent anti-tumor effects of letrozole were demonstrated in several animal models. Studies with MCF-7Ca xenografts successfully predicted that letrozole would be clinically superior to the previous gold standard tamoxifen and also indicated that it may be more effective than other AIs. An extensive program of randomized clinical trials has demonstrated the clinical benefits of letrozole across the spectrum of hormone-responsive breast cancer in postmenopausal women.

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Aromatase Inhibitors Prevent Spontaneous Granular Cell Tumors in the Distal Female Reproductive Tract of Sprague-Dawley Rats

Cited by 7 publications

References 10 publications

Granular Cell Tumor of the Trachea in Pregnancy: A Case Report and Review of Literature

Granular Cell Tumor of the Trachea in Pregnancy: A Case Report and Review of Literature

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

The discovery and mechanism of action of letrozole

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