Benign acute viral myositis in African migrants: A clinical, serological, and pathological study

Pancheri, Elia; Lanzafame, Massimiliano; Zamò, Alberto; Angheben, Andrea; Sartoris, Silvia; Zorzi, Antonella; Boaretti, Marzia; Signoretto, Caterina; Guglielmi, Valeria; Ferrari, Sergio; Tonin, Paola; Vattemi, Gaetano

doi:10.1002/mus.26679

Cited by 9 publications

(11 citation statements)

References 8 publications

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“…BACM can occur sporadically or in epidemics. Several authors have confirmed the association with Influenza B [3] and other viruses, including Influenza A, Parainfluenza, Adenovirus, Coxsackievirus, and Mycoplasma pneumoniae [4][5][6]. Recurrence of BACM in the same individual has been occasionally described [1].…”

Section: Introductionmentioning

confidence: 90%

Management and outcome of benign acute childhood myositis in pediatric emergency department

et al. 2021

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Background Benign acute childhood myositis (BACM) is a self-limited syndrome associated with viral infections characterized by symmetric lower extremity pain typically affecting school-aged children. Evolution in rhabdomyolysis and kidney damage is rarely reported. Despite this, the acute presentation commonly concerns both parents and health care providers, often leading to unnecessary workup. The aim of the study was to determine the features and outcome of a large series of children with BACM identifying a management pathway for pediatricians in Emergency Department (ED). Methods We conducted a retrospective study of patients with BACM managed in 2 Italian pediatric ED during a period of 8 and a half years. Demographic data, clinical, and laboratory results were extracted from electronic medical records. Recurrence, complications, treatments, and outcomes were also recorded. Descriptive statistics were produced for first-episode patients and for those with recurrence of myositis. A comparison between groups was performed. Results One hundred and thirteen patients with BACM were identified. Ninety-two children (65 males) had a single episode, while ten (nine males) had recurrence. The mean age at presentation was 6.0 years (range 2–13,2). All patients had normal neurological examination and no one developed myoglobinuria, or renal failure. At first evaluation median CK level was 1413 UI/l (normal values < 150 U/L). Median CK of “recurrent” patients was higher than “non-recurrent” (2330 vs 1150 U/L, p = 0.009). Viral studies were positive in 51/74 cases, with high prevalence of Influenza viruses. Ninety-six patients (85%) were hospitalized with a median of 4 days. No patients had any residual muscular impairment. Conclusions BACM has an excellent prognosis. Severe pathological conditions can be excluded with a complete history and clinical examination and simple blood and urine tests, avoiding unnecessary diagnostic investigations. Most patients may be discharged home from ED recommending hydration, rest, analgesics and careful follow-up.

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Section: Introductionmentioning

confidence: 90%

Management and outcome of benign acute childhood myositis in pediatric emergency department

et al. 2021

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“…There may be myopathic changes on the electromyogram. However, the diagnosis of myositis does not require muscle biopsy but rather is diagnosed clinically in the setting of viral infection [4,6]. Influenza A/B target RNA was checked during admission for our patient with subsequent negative results that narrowed down the cause of rhabdomyolysis to be likely secondary to COVID-19 viral myositis.…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, circulating viral toxins directly attacking the myocyte membranes could damage muscle fibers [11]. Some evidence of T-cell-mediated injury was shown on muscle biopsy in some cases of patients with viral myositis [6].…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Coronavirus Disease 2019 (COVID-19) Induced Viral Myositis With Subsequent Rhabdomyolysis

Zhang¹,

Shan²,

Minalyan³

et al. 2020

Cureus

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“…A heightened immunologic reaction resulting in "cytokine storm" can further lead to disseminated tissue damage including rhabdomyolysis [7,11]. Cytotoxic T-cell-mediated attack has also been demonstrated to cause muscular injury in viral myositis [12]. Our knowledge of the novel disease, Covid-19, is still evolving, and the exact mechanism of rhabdomyolysis due to SARS-CoV-2 is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis in a Patient With Coronavirus Disease 2019

Mukherjee¹,

Ghosh²,

Aftab³

2020

Cureus

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Coronavirus disease 2019 has rapidly enveloped the world in a pandemic after emerging in Wuhan, China, in December 2019. We describe a 49-year-old man presenting with fever, cough, dyspnea, and myalgia diagnosed with coronavirus disease 2019 along with rhabdomyolysis and acute kidney injury. The creatine phosphokinase was elevated to 23,800 U/L before trending down to normal levels. Rapid identification and treatment with aggressive intravenous hydration and correction of electrolyte abnormalities remain key to successful management. In a pandemic, often atypical presentations of this new disease have to be considered as differentials for early diagnosis and treatment of life-threatening conditions.

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Benign acute viral myositis in African migrants: A clinical, serological, and pathological study

Cited by 9 publications

References 8 publications

Management and outcome of benign acute childhood myositis in pediatric emergency department

Management and outcome of benign acute childhood myositis in pediatric emergency department

A Rare Presentation of Coronavirus Disease 2019 (COVID-19) Induced Viral Myositis With Subsequent Rhabdomyolysis

Rhabdomyolysis in a Patient With Coronavirus Disease 2019

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