Benefits of supplementation with multiple micronutrients in pregnancy

Black, Robert E.; Dewey, Kathryn G.

doi:10.1111/nyas.14088

Cited by 12 publications

(10 citation statements)

References 13 publications

(20 reference statements)

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“…Consequently, micronutrient deficiencies in pregnancy are associated with adverse pregnancy and birth outcomes, such as maternal mortality, pregnancy loss, birth defects, low birth weight (LBW), risk of death in infancy, stunting, and may influence long-term outcomes for the offspring, such as cognitive development and cardiometabolic risk. 1,3,4 Nevertheless, prenatal micronutrient supplementation can efficaciously address these micronutrient gaps and, in turn, reduce the risk of negative pregnancy and birth outcomes. Prenatal multiple micronutrient supplements, containing 15 vitamins and minerals, have been shown to be a cost-effective method to decrease the risk of stillbirth, LBW, preterm birth (PB), and being born small-for-gestational-age.…”

Section: Introductionmentioning

confidence: 99%

Interventions to increase adherence to micronutrient supplementation during pregnancy: a protocol for a systematic review

Gomes

Bergeron

Bourassa

et al. 2020

Annals of the New York Academy of Sciences

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Micronutrient supplementation during pregnancy has been shown to be a cost‐effective method to reduce the risk of adverse pregnancy and birth outcomes. However, one of the main barriers to the successful implementation of a micronutrient supplementation program in pregnancy is poor adherence. Our review will assess the effectiveness of interventions designed to increase adherence to micronutrient supplements in pregnancy. Following the Cochrane Collaboration Methodology, we will start by conducting the literature searches on Medline (via PubMed), Embase, Scopus, Web of Science, and Cochrane Library, in addition to sources of gray literature, to retrieve all the available relevant studies. We will include randomized controlled trials and nonrandomized studies with a control group, where participants are pregnant women taking any micronutrient supplements in the context of antenatal care globally. We will include studies with targeted interventions designed to improve adherence to micronutrient supplementation in pregnant women compared with (1) usual care or no intervention or (2) other targeted micronutrient adherence intervention. Abstract selection, data extraction, and risk of bias assessment (according to the type of studies) will be conducted by two independent reviewers. The pooled results will be reported using the standardized mean differences for continuous data, and odds ratio or risk ratio for dichotomous data. We will assess sources of heterogeneity and publication bias. By following this protocol, we will systematically assess and synthesize the existing evidence about interventions designed to increase adherence to micronutrient supplementation in pregnant women. Understanding which strategies are more effective to increase the consumption of micronutrient supplements during this critical stage of life will have significant implications for clinicians and policymakers involved in the delivery of prenatal micronutrient supplementation interventions.

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Section: Introductionmentioning

confidence: 99%

Interventions to increase adherence to micronutrient supplementation during pregnancy: a protocol for a systematic review

Gomes

Bergeron

Bourassa

et al. 2020

Annals of the New York Academy of Sciences

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“…Furthermore, strategies to improve iron bioavailability and absorption, as well as food security at the household level are needed, alongside the effective monitoring of food industries to ensure food fortification is according to standard. We also recommend that the country’s policies and programmes on nutrition need to be reviewed with particular attention paid to WRA, children under 5 years old, and WRA living with HIV/AIDS, while multiple micronutrient supplementation (MMS) is intensified [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Anaemia, Iron Deficiency, and Iron Deficiency Anaemia in Women of Reproductive Age and Children under 5 Years of Age in South Africa (1997–2021): A Systematic Review

Turawa

Awotiwon

Dhansay

et al. 2021

IJERPH

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Using a systematic review method, the prevalence of anaemia, iron deficiency (ID), and iron deficiency anaemia (IDA) in women of reproductive age (WRA) and children under 5 years of age was obtained to inform priorities in health planning and policy in South Africa. We searched electronic databases for articles published between 1997 and 2021. A total of 713 articles were identified, of which 14 articles comprising 9649 WRA and 4085 children were included. Since most of the included studies were of low quality, we did not pool data in a meta-analysis due to heterogeneity (I2 > 75%). In WRA, anaemia prevalence ranged from 22.0% to 44.0%; ID from 7.7% and 19.0%; and IDA from 10.5% to 9.7%. The prevalence of anaemia in pregnancy was 29.0% to 42.7%; and 60.6% to 71.3% in HIV-infected pregnant women. Three national surveys reported anaemia in children at 28.9%, 10.7%, and 61.3%, respectively. Overall, among the children under 5 years old, anaemia was more prevalent in 1-year-olds (52.0%) compared to the other age groups. Between 2005 and 2012, ID increased by 3.8% and IDA decreased by 83.2% in children. Anaemia in WRA and children under 5 years in South Africa was a moderate public health concern. Therefore, interventions addressing anaemia should be intensified, and policies on iron supplementation and food fortification need to be revised and aligned to the WHO multiple micronutrient supplementation recommendations.

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“…Prenatal multiple micronutrient supplementation (MMS) provides a good solution to supply those essential nutrients. A series of publications recently put forward by the New York Academy of Sciences (NYAS) presented evidence of the benefits of MMS on maternal and perinatal outcomes (i.e., significant risk reduction of LBW, SGA, preterm birth, and stillbirth), in addition to those provided by iron and folic acid . These publications identify populations in low‐ and middle‐income countries (LMIC), where a switch to MMS would be justified, consistent with the WHO Antenatal Care Guidelines, and would be highly cost‐effective .…”

Section: Introductionmentioning

confidence: 99%

Setting research priorities on multiple micronutrient supplementation in pregnancy

Gomes

Bourassa

Adu‐Afarwuah

et al. 2019

Annals of the New York Academy of Sciences

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Prenatal micronutrient deficiencies are associated with negative maternal and birth outcomes. Multiple micronutrient supplementation (MMS) during pregnancy is a cost‐effective intervention to reduce these adverse outcomes. However, important knowledge gaps remain in the implementation of MMS interventions. The Child Health and Nutrition Research Initiative (CHNRI) methodology was applied to inform the direction of research and investments needed to support the implementation of MMS interventions for pregnant women in low‐ and middle‐income countries (LMIC). Following CHNRI methodology guidelines, a group of international experts in nutrition and maternal health provided and ranked the research questions that most urgently need to be resolved for prenatal MMS interventions to be successfully implemented. Seventy‐three research questions were received, analyzed, and reorganized, resulting in 35 consolidated research questions. These were scored against four criteria, yielding a priority ranking where the top 10 research options focused on strategies to increase antenatal care attendance and MMS adherence, methods needed to identify populations more likely to benefit from MMS interventions and some discovery issues (e.g., potential benefit of extending MMS through lactation). This exercise prioritized 35 discrete research questions that merit serious consideration for the potential of MMS during pregnancy to be optimized in LMIC.

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Benefits of supplementation with multiple micronutrients in pregnancy

Cited by 12 publications

References 13 publications

Interventions to increase adherence to micronutrient supplementation during pregnancy: a protocol for a systematic review

Interventions to increase adherence to micronutrient supplementation during pregnancy: a protocol for a systematic review

Prevalence of Anaemia, Iron Deficiency, and Iron Deficiency Anaemia in Women of Reproductive Age and Children under 5 Years of Age in South Africa (1997–2021): A Systematic Review

Setting research priorities on multiple micronutrient supplementation in pregnancy

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