Interventions to increase adherence to micronutrient supplementation during pregnancy: a protocol for a systematic review

Abstract

Micronutrient supplementation during pregnancy has been shown to be a cost‐effective method to reduce the risk of adverse pregnancy and birth outcomes. However, one of the main barriers to the successful implementation of a micronutrient supplementation program in pregnancy is poor adherence. Our review will assess the effectiveness of interventions designed to increase adherence to micronutrient supplements in pregnancy. Following the Cochrane Collaboration Methodology, we will start by conducting the literature searches on Medline (via PubMed), Embase, Scopus, Web of Science, and Cochrane Library, in addition to sources of gray literature, to retrieve all the available relevant studies. We will include randomized controlled trials and nonrandomized studies with a control group, where participants are pregnant women taking any micronutrient supplements in the context of antenatal care globally. We will include studies with targeted interventions designed to improve adherence to micronutrient supplementation in pregnant women compared with (1) usual care or no intervention or (2) other targeted micronutrient adherence intervention. Abstract selection, data extraction, and risk of bias assessment (according to the type of studies) will be conducted by two independent reviewers. The pooled results will be reported using the standardized mean differences for continuous data, and odds ratio or risk ratio for dichotomous data. We will assess sources of heterogeneity and publication bias. By following this protocol, we will systematically assess and synthesize the existing evidence about interventions designed to increase adherence to micronutrient supplementation in pregnant women. Understanding which strategies are more effective to increase the consumption of micronutrient supplements during this critical stage of life will have significant implications for clinicians and policymakers involved in the delivery of prenatal micronutrient supplementation interventions.

Knowledge and awareness of folic acid usage in Saudi pregnant women in Riyadh city from 2019-2020

“…Both (folic acid and folate) have similar chemical structure but known to be unidentical. [ 8 9 ] Globally, two billion individuals were affected by deficiencies of vitamins and minerals known as hidden hunger; negatively impact on health and economic improvement. [ 10 ] During the time of earlier pregnancies, maternal folate inefficiency is allied with increased risks of anemia, pregnancy complications with offspring birth-defects.…”

Interventions to increase adherence to micronutrient supplementation during pregnancy: a systematic review

“…This systematic review followed the Cochrane Collaboration Methodology 18 and the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) reporting guidelines, 19 as described in a previously published protocol. 20 The protocol has also been registered on the International Prospective Register of Systematic Reviews (PROSPERO), the University of York Centre for Reviews and Dissemination (https://www. crd.york.ac.uk/prospero/; registration number CRD42019146814).…”

“…This systematic review followed the Cochrane Collaboration Methodology 18 and the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) reporting guidelines, 19 as described in a previously published protocol 20 …”

“…Subgroup and sensitivity analyses were initially planned as per the protocol, 20 but the inability to conduct a meta‐analysis rendered this impossible.…”

Considerations for conducting systematic reviews: evaluating the performance of different methods for de-duplicating references

“…At the database platform level, search results retrieved from different databases available via Ovid, such as MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL), can be de-duplicated using Ovid multifile search [8]. Reference management software such as End-Note, Mendeley, RefWorks, and Zotero have long provided de-duplication functionality, and researchers have previously reported utilizing such tools for this purpose [9][10][11][12]. More recently, software programs specifically developed to facilitate the production of systematic reviews and other syntheses are starting to offer de-duplication functionality, including both proprietary (e.g., Covidence and DistillerSR) and free options (e.g., Rayyan) [13,14].…”