Benefits of Physical Activity for Depression and Fatigue in Multiple Sclerosis: A Longitudinal Analysis

Stephens, Samantha; Shams, Shahriar; Lee, Joshua; Grover, Stephanie A.; Longoni, Giulia; Berenbaum, Tara; Finlayson, Marcia; Motl, Robert W.; Yeh, E. Ann

doi:10.1016/j.jpeds.2019.01.040

Cited by 39 publications

(23 citation statements)

References 19 publications

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“…Grover et al [104,105] found that adolescents with less perception of their physical limitations and those scoring higher on the "Physical Activity Self-Efficacy Scale" and the "Exercise Goal-Setting Scale" were more likely to participate in moderate and vigorous exercise. However, the authors did not find a correlation between level of exercise and depression or fatigue, which contrasts with another recent publication that demonstrated less fatigue and depression in those undertaking moderate to vigorous exercise in POMS [106].…”

Section: Exercisecontrasting

confidence: 92%

Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

2021

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Pediatric-onset multiple sclerosis (POMS), representing approximately 5% of all MS cases, affects the central nervous system during its ongoing development. POMS is most commonly diagnosed during adolescence but can occur in younger children as well. For pediatric patients with MS, it is critical to manage the full impact of the disease and monitor for any effects on school and social functioning. Disease management includes not only disease-modifying therapies but also strategies to optimize wellbeing. We review the interventions with the highest evidence of ability to improve the disease course and quality of life in POMS. High levels of vitamin D and a diet low in saturated fat are associated with lower relapse rates. Exercise ameliorates fatigue and sleep. Behavioral strategies for sleep hygiene and mood regulation can also improve fatigue and perceived health. POMS management should be addressed holistically, including assessing overall symptom burden as well as the psychological and functional impact of the disease.

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Section: Exercisecontrasting

confidence: 92%

Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

2021

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“…1,2,4 Participation in MVPA further has been associated with lower symptoms of depression and fatigue. 1–3 Collectively, these findings suggest that MVPA may play an important role in health outcome in youth with MS. 3 The observational nature of these studies limits the determination of causality or the direction of the relationship between physical activity, disease activity, and symptoms of fatigue and depression, and those might be inter-related by a third variable such as physical fitness.…”

Section: Introductionmentioning

confidence: 96%

“…Moderate-to-vigorous physical activity (MVPA) is associated with improved health outcomes in youth with MS. [1][2][3] In our previous work, we have demonstrated that youth with MS who had higher levels of MVPA exhibited lower disease activity, disease burden, and disability. 1,2,4 Participation in MVPA further has been associated with lower symptoms of depression and fatigue.…”

Section: Introductionmentioning

confidence: 99%

Youth with multiple sclerosis have low levels of fitness

et al. 2020

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Background: Moderate and vigorous physical activity is associated with improved outcomes in youth with multiple sclerosis (MS). Physical fitness may also influence disease and health outcomes in this population. Objectives: To determine if there were differences in physical fitness between youth with MS and healthy controls (HC). To examine relationships between physical fitness, physical activity (PA) level, fatigue, depression and disease activity in youth with MS and HC. Methods: Youth with MS ( n = 19) and HC ( n = 21) completed tests establishing cardiorespiratory-fitness (VO2peak), endurance via 2-minute walk test, and musculoskeletal strength via grip strength (GS). Questionnaires determined fatigue, depression, and PA levels. Weekly PA level was determined by accelerometry. Tests of differences and correlational analyses were used to evaluate physical fitness. Results: Youth with MS had lower VO2peak ( U = 279, p < 0.0001), endurance ( t = 2.6, p = 0.02), and higher body mass index (BMI) ( t = -5.9, p = 0.001) than HC. Higher VO2peak was associated with higher moderate to vigorous PAaccelerometer in HC (Spearman-Rho = 0.5, p = 0.03), but not in youth with MS (Spearman-Rho = 0.5, p = 0.06). Lower VO2peak and GS were associated with higher disability (Spearman-Rho = -0.6, p = 0.03) and relapses in MS (Spearman-Rho = -0.52, p = 0.04). Conclusions: Youth with MS have lower levels of fitness, compared with HC. Higher levels of fitness were associated with lower disease activity and disability in youth with MS.

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“…Rainone et al (2017) found that resilience appears to be a protective factor in QoL [70], but its positive effect decreases precisely by the action of negative emotions [71]. Therefore, specifical psychological assistance and social support [72][73][74] are very important to improve the emotional status, because the prevalence of mental problems in children with MS is high [44,75,76] and rises with the lengthening duration of the disease [77].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life of Children and Adolescents with Multiple Sclerosis—A Literature Review of the Quantitative Evidence

Mrosková

Klímová

Majerníková

et al. 2021

IJERPH

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Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system that also develops in patients under 18 years of age. The disease negatively affects the quality of life (QoL) of children and adolescents. We conducted a literature review. The aim of the review was to identify the QoL of pediatric patients with MS and assess the factors determining their QoL. Methods: We analyzed studies published between 2000 and 2020 in PubMed, Scopus, Science Direct, Web of Science, and EBSCO databases. Results: In all, 17 studies were included in the review. The most common tool in assessing QoL was the generic module PedsQL. The range of mean/median global score of QoL was 53.8–81.7. The worst QoL was dominantly reported in the school and emotional spheres, on the contrary, the disease’s least determined area of QoL was the social and physical dimension. In particular, disability and fatigue were important predictors of QoL. Conclusions: MS negatively affects the school and emotional spheres in particular, so it is important to pay greater attention to these spheres of life of MS patients. As the review studies pay insufficient attention to the analysis of positive factors and their impact on the QoL of MS patients, research should integrate these phenomena. The use of MS-targeted tools in future research in the pediatric MS population is also appropriate.

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Benefits of Physical Activity for Depression and Fatigue in Multiple Sclerosis: A Longitudinal Analysis

Cited by 39 publications

References 19 publications

Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

Youth with multiple sclerosis have low levels of fitness

Quality of Life of Children and Adolescents with Multiple Sclerosis—A Literature Review of the Quantitative Evidence

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