Benefits of Multimodal Exercise Intervention for Postural Control and Frontal Cognitive Functions in Individuals with Alzheimer's Disease: A Controlled Trial

Andrade, Larissa Pires de; Gobbi, Lilian Teresa Bucken; Coelho, Flávia G. M.; Christofoletti, Gustavo; Costa, José Luiz Riani; Stella, Florindo

doi:10.1111/jgs.12531

Cited by 117 publications

(112 citation statements)

References 56 publications

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“…Previous studies have indicated that a physical exercise program improves mobility of people with AD [12][13][14] . However, the interventions in these studies were focused only on the components of physical capacity (i.e., muscle strength, endurance, balance, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have developed an exercise program with cognitive load 14,16,17 . These studies showed that cognitive exercise, besides improving the frontal cognitive functions, such as abstraction, organization, motor sequencing, behavioral self-control and attention, also improves stride length and performance during dual task in people with AD.…”

Section: Introductionmentioning

confidence: 99%

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A program of physical activity improves gait impairment in people with Alzheimer's disease

Orcioli‐Silva

Barbieri

Simieli

et al. 2018

Motriz: rev. educ. fis.

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-Aim:This study aimed to identify the effects of aging and Alzheimer's disease (AD) on gait parameters after a four-month period and to investigate the effects of a four-month program of physical activity, with emphasis on the cognitive components of gait during single and dual task, in people with AD. Methods: Twenty-three people with AD, divided into the Training Group (TG; n=12; aged 79.17±7.62 years) and the Control Group (CG; n=11; aged 77.00±5.57 years), and eleven healthy older adults (Healthy Group -HG; aged 75.82±4.83 years) were included in this study. TG participated in a physical activity program for four months. The CG and HG were instructed not to participate in any kind of regular physical activity in this period. The physical activity program includes motor activities and cognitive tasks simultaneously. The participants attended a 1-h session three times a week. The kinematic parameters of gait were analyzed under two conditions, before and after a physical activity program: single and dual task. Deltas for all dependent variables between pre and post training were calculated. The deltas were compared using two-way ANOVAs with group (TG x CG and CG x HG) and task (single x dual task) as factors, with repeated measures for task. Results: After the training period, the TG improved stride length, duration, velocity and cadence compared to the CG. Conclusion: Physical activity with emphasis on cognitive components promotes better reallocation of attention while walking in people with AD, improving attentional focus on the gait and thus resulting in a safer locomotive pattern.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A program of physical activity improves gait impairment in people with Alzheimer's disease

Orcioli‐Silva

Barbieri

Simieli

et al. 2018

Motriz: rev. educ. fis.

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“…Despite this shortcoming, it has been consistently reported that exercise is associated with a reduced risk of dementia and the level of reported physical activity correlates with the incidence of dementia across a number of studies (Andel et al, 2008;Buchman et al, 2012;Larson et al, 2006;Ravaglia et al, 2008). Randomised controlled trials, although few in number, also support exercise as a pro-cognitive intervention in individuals diagnosed with dementia (de Andrade et al, 2013;Kemoun et al, 2010;Van de Winckel et al, 2004;Venturelli et al, 2011;Vreugdenhil et al, 2012). Recently, Coelho et al (2014) reported an increase in plasma BDNF levels in AD patients and healthy controls following a single bout of exercise on the treadmill, this result however was not accompanied by any cognitive testing.…”

Section: Exercise In the Clinicmentioning

confidence: 99%

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

Ryan

Kelly

2016

Ageing Research Reviews

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a b s t r a c tIt is now well established, at least in animal models, that exercise elicits potent pro-cognitive and proneurogenic effects. Alzheimer's disease (AD) is one of the leading causes of dementia and represents one of the greatest burdens on healthcare systems worldwide, with no effective treatment for the disease to date. Exercise presents a promising non-pharmacological option to potentially delay the onset of or slow down the progression of AD. Exercise interventions in mouse models of AD have been explored and have been found to reduce amyloid pathology and improve cognitive function. More recent studies have expanded the research question by investigating potential pro-neurogenic and anti-inflammatory effects of exercise. In this review we summarise studies that have examined exercise-mediated effects on AD pathology, cognitive function, hippocampal neurogenesis and neuroinflammation in transgenic mouse models of AD. Furthermore, we attempt to identify the optimum exercise conditions required to elicit the greatest benefits, taking into account age and pathology of the model, as well as type and duration of exercise.© 2016 Elsevier B.V. All rights reserved. Please cite this article in press as: Ryan, S.M., Kelly, Á.M., Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease. Ageing Res. Rev. (2016), http://dx

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“…9 Its relation to dysfunctions of the respiratory tract can be linked with the subject's physical decline, arising, above all, from the depletion in the levels of acetylcholine and changes in the N-methyl-D-aspartate receptors in the brain. 10,11 Although these conditions present psychological-behavioral and neuromotor impairments as the principal dysfunctions, one must also consider the influence of the brain alterations in RMS. Hence, it is necessary to evaluate the subjects' pulmonary function so as to ascertain the need to establish a guided and efficacious therapeutic plan for patients with such conditions.…”

Section: Introductionmentioning

confidence: 99%

Neurodegenerative Disorders Increase Decline in Respiratory Muscle Strength in Older Adults

et al. 2014

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, and control (n ‫؍‬ 25). The participants underwent anthropometric and cirtometric measurements associated with maximal respiratory pressures. We analyzed data using descriptive (mean and SD) and inferential statistics (1-way analysis of variance, Student t test, and Scheffé post hoc) with a level of significance of 5% (P < .05) and a CI of 95%. RESULTS: Although the anthropometric and cirtometric variables indicated similarity of values between groups (P > .05), the maximal inspiratory and expiratory pressures were considerably lower in the subjects with PD and AD (P < .01). CONCLUSIONS: The control of the anthropometric and cirtometric variables of the subjects indicates that RMS is affected by the aging process, and its decline increases in neurodegenerative conditions. This fact represents a serious risk for the development of atelectasis and other pneumo-functional complications, which must be considered in proposing of future therapies.

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Benefits of Multimodal Exercise Intervention for Postural Control and Frontal Cognitive Functions in Individuals with Alzheimer's Disease: A Controlled Trial

Abstract: Intervention participants performed better on dual-task activities and had better postural balance and greater functional capacity than controls.

Cited by 117 publications

References 56 publications

A program of physical activity improves gait impairment in people with Alzheimer's disease

A program of physical activity improves gait impairment in people with Alzheimer's disease

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

Neurodegenerative Disorders Increase Decline in Respiratory Muscle Strength in Older Adults

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