Benefits of Anti-Aging Actives in Sunscreens

Lintner, Karl

doi:10.3390/cosmetics4010007

Cited by 9 publications

(8 citation statements)

References 20 publications

(21 reference statements)

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“…Formation of skin wrinkles is a phenotype of the aging process [51,52], which is affected by several factors including genetic changes, hormonal alteration, UVB irradiation, and exposure to inflammationor oxidation-inducing agents [1,12,38]. In terms of cellular and molecular causes of wrinkle formation, a decrease of extracellular matrix proteins such as collagen in dermal fibroblasts is known as a major cause [53].…”

Section: Discussionmentioning

confidence: 99%

Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P

Lim

Jeong

Park

et al. 2020

IJMS

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UVB irradiation can induce generation of reactive oxygen species (ROS) that cause skin aging or pigmentation. Lactobacillus acidophilus is a well-known probiotic strain that regulates skin health through antimicrobial peptides and organic products produced by metabolism and through immune responses. In this study, we investigated the antioxidative, antiwrinkle, and antimelanogenesis effects of tyndallized Lactobacillus acidophilus KCCM12625P (AL). To analyze the effects of AL on UV irradiation-induced skin wrinkle formation in vitro, human keratinocytes and human dermal fibroblasts were exposed to UVB. Subsequent treatment with AL induced antiwrinkle effects by regulating wrinkle-related genes such as matrix metalloproteinases (MMPs), SIRT-1, and type 1 procollagen (COL1AL). In addition, Western blotting assays confirmed that regulation of MMPs by AL in keratinocytes was due to regulation of the AP-1 signaling pathway. Furthermore, we confirmed the ability of AL to regulate melanogenesis in B16F10 murine melanoma cells treated with α-melanocyte-stimulating hormone (α-MSH). In particular, AL reduced the mRNA expression of melanogenesis-related genes such as tyrosinase, TYRP-1, and TYRP-2. Finally, we used Western blotting assays to confirm that the antimelanogenesis role of AL was due to its regulation of the cyclic adenosine monophosphate (cAMP) signaling pathway. Collectively, these results indicate that AL has an antiwrinkle activity in damaged skin and can inhibit melanogenesis. Thus, AL should be considered an important substance for potential use in anti-aging drugs or cosmetics.

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Section: Discussionmentioning

confidence: 99%

Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P

Lim

Jeong

Park

et al. 2020

IJMS

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“…23 These bacteria live close to the hydrothermal vents at the bottom of the ocean at extremely high temperatures (Table 1). 25 Delivery:…”

Section: Phytoene and Phytofluenementioning

confidence: 99%

“…Antioxidant enzymes can be used to protect the skin, but the instability of enzymes makes them hard to formulate. 25 The skin's intrinsic enzymes can be rapidly overwhelmed by excessive sun exposure. To counteract this impact, we can either stimulate or protect the existing enzymes or supply the lacking enzymes by a topical application.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

Widgerow,

Ziegler,

Garruto

et al. 2023

J of Cosmetic Dermatology

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BackgroundThis paper describes the background research and validation related to the formulation of a novel antioxidant product. Two defined outcomes were sought. Firstly, a combined efficacy of antioxidant ingredients in quenching free oxygen radicals. Secondly, the investigation into whether a vitamin C derivative sodium salt was elastin conserving in contrast to current vitamin C/l‐ascorbic acid variations that have been reported to negatively affect elastin constitution and regeneration.Materials and MethodsA leading l‐ascorbic acid antioxidant available on the market was compared with the experimental new product in two studies. In the first experiment, the products were compared to assess their antioxidant properties. The evaluated products TOPICAL ANTIOXIDANT 1 and TOPICAL ANTIOXIDANT 2 were applied to human skin cultures (25–30 mg/cm2) for a total of 72 h of treatment and exposed to oxidative stress. The generation of free radicals was semi‐quantitatively assessed by measuring the fluorescence intensity of the deacetylation and oxidation of the probe dichlorofluorescein diacetate (DCFH‐DA). In the second experiment, an ex vivo skin model (derived from patients undergoing facelift procedures) was used to assess elastin preservation. Three skin explants were topically subjected to the two formulations daily for 7 days. The skin was then prepared and fixed for immunofluorescent assessment after staining with CD44 and tropoelastin antibodies. Images were then analyzed using ImageJ.ResultsA full description of the different components selected for the new formulation is presented. In the first study, the experimental formulation performed with absolute equivalence to the comparator in its radical quenching capacity; both showed extremely effective antioxidant function. In the second study, the comparator negatively affected the existing elastin with areas of breakdown and diminished staining. In contrast, the new formulation showed good conservation of healthy elastin in all sections demonstrating elastin preservation.ConclusionA new antioxidant formulation was carefully designed with multiple actives that show an equivalent antioxidant capacity to a leading product on the market. More importantly, the vitamin C component shows direct elastin conservation and improvement as opposed to the comparator, which had negative effects on elastin preservation. This is in keeping with little‐known literature reports on vitamin C and its negative effects on elastin and validates the use of a sodium salt derivative, which appears to have protective effects on elastin. These findings support the overall regenerative extracellular matrix changes seen with TriHex® technology in other products.

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“…Body odor is caused by the growth of microorganisms, and odors are associated with perspiration and its breakdown by bacteria in the armpits, feet, or any other part of the body [ 9 ]. Many products claim to have skin benefits, such as anti-aging [ 10 ], skin tightening, and moisturizing activity [ 11 ]. In general, the preparation of deodorant is carried out using emulsion systems, where the active ingredients are mixed with waxes, oils, and silicones and produced in the desired form, such as deodorant cream, gel, roll-ons, and sticks [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

et al. 2022

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Carboxymethyl chitosan (CMCH) from native chitosan of high molecular weight (H, 310–375 kDa) was synthesized for improving water solubility. The water solubility of high-molecular-weight carboxymethyl chitosan (H-CMCH) was higher than that of native chitosan by 89%. The application of H-CMCH as enhancing the moisturizer in mangosteen extract deodorant cream was evaluated. Different concentrations of H-CMCH (0.5–2.5%) were investigated in physicochemical characteristics of creams, including appearance, phase separation, pH, and viscosity, by an accelerated stability test. The different degrees of skin moisturizing (DM) on pig skin after applying H-CMCH solution, compared with untreated skin, water, and propylene glycol for 15 and 30 min using a Corneometer®, were investigated. The results showed that the 0.5% H-CMCH provided the best DM after applying the solution on pig skin for 30 min. Trans-2-nonenal, as an unsatisfied odor component, was also evaluated against components of the mangosteen extract deodorant cream, which were compared to the standard, epigallocatechin gallate (EGCG). In addition, DPPH and ABTS radical scavenging activity, ferric reducing antioxidant power (FRAP), and antibacterial activities were examined for the mangosteen extract deodorant cream using 0.5% H-CMCH. Results indicated that the mangosteen extract synergized with H-CMCH, which had a good potential as an effective skin moisturizing agent enhancer, deodorizing activity on trans-2-nonenal odor, antioxidant properties, and antibacterial properties.

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Benefits of Anti-Aging Actives in Sunscreens

Cited by 9 publications

References 20 publications

Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P

Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

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