Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature

Inchingolo, Alessio Danilo; Malcangi, Giuseppina; Inchingolo, Angelo Michele; Piras, Fabio; Settanni, Vito; Garofoli, Grazia; Palmieri, Giulia; Ceci, Sabino; Patano, Assunta; Leonardis, Nicole De; Pede, Chiara Di; Montenegro, Valentina; Azzollini, Daniela; Garibaldi, Maria Grazia; Kruti, Zamira; Tarullo, A; Coloccia, Giovanni; Mancini, Antonio; Rapone, Biagio; Semjonova, Alexandra; Hazballa, Denisa; D’Oria, Maria Teresa; Jones, Megan M.; Macchia, Luigi; Bordea, Ioana Roxana; Scarano, Antonio; Lorusso, Felice; Tartaglia, Gianluca Martino; Maspero, Cinzia; Fabbro, Massimo Del; Nucci, Ludovica; Ferati, Kenan; Ferati, Arberesha Bexheti; Brienza, Nicola; Corriero, Alberto; Inchingolo, Francesco; Dipalma, Gianna

doi:10.3390/ijms23074027

Cited by 44 publications

(44 citation statements)

References 298 publications

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“…Understanding the mechanisms would help avoid hospitalizations, intensive care, and deaths from SARS-CoV-2. Some hypotheses have emerged from recent genomic studies [ 159 , 160 , 161 , 162 ]. In fact, these studies have revealed two important facts.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast

Inchingolo

Malcangi

Ceci

et al. 2022

IJMS

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Background: The recent COVID-19 pandemic produced a significant increase in cases and an emergency state was induced worldwide. The current knowledge about the COVID-19 disease concerning diagnoses, patient tracking, the treatment protocol, and vaccines provides a consistent contribution for the primary prevention of the viral infection and decreasing the severity of the SARS-CoV-2 disease. The aim of the present investigation was to produce a general overview about the current findings for the COVID-19 disease, SARS-CoV-2 interaction mechanisms with the host, therapies and vaccines’ immunization findings. Methods: A literature overview was produced in order to evaluate the state-of-art in SARS-CoV-2 diagnoses, prognoses, therapies, and prevention. Results: Concerning to the interaction mechanisms with the host, the virus binds to target with its Spike proteins on its surface and uses it as an anchor. The Spike protein targets the ACE2 cell receptor and enters into the cells by using a special enzyme (TMPRSS2). Once the virion is quietly accommodated, it releases its RNA. Proteins and RNA are used in the Golgi apparatus to produce more viruses that are released. Concerning the therapies, different protocols have been developed in observance of the disease severity and comorbidity with a consistent reduction in the mortality rate. Currently, different vaccines are currently in phase IV but a remarkable difference in efficiency has been detected concerning the more recent SARS-CoV-2 variants. Conclusions: Among the many questions in this pandemic state, the one that recurs most is knowing why some people become more seriously ill than others who instead contract the infection as if it was a trivial flu. More studies are necessary to investigate the efficiency of the treatment protocols and vaccines for the more recent detected SARS-CoV-2 variant.

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Section: Discussionmentioning

confidence: 99%

“…Positive CT thoracic with ground glass opacity indicative for interstitial bilateral alveolar pneumonia to be performed immediately in patients with P/F < 300 mmHg [ 159 , 160 , 161 ].…”

Section: Covid-19 Syndrome: Diagnosis and Treatment Procedures At Hom...mentioning

confidence: 99%

Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast

Inchingolo

Malcangi

Ceci

et al. 2022

IJMS

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“…A systematic review study analyzed that the beneficial activity of resveratrol is evidenced by analyzing the changes in the gene expression of the host and the gastrointestinal microbial community with its administration. The possibility of identifying individual microbial families may allow tailoring treatment plans with targeted polyphenolic diets when associated with microbial dysbioses, such as bone tissue regeneration [34].…”

Section: Vol 3 Suppl 6 Year 2022mentioning

confidence: 99%

“…The gut microbiota is composed of about 100 trillion bacteria, viruses, fungi, and protozoa that live in perfect symbiosis with our organism [33]. About 90% of bacteria living in the human gastrointestinal tract belong to 5 main phyla: Bacteroidetes characterized by some well-known genera such as Prevotella and Bacteroides [34], Firmicutes to which the genera Ruminococcus, Lactobacillus and Streptococcus belong [34]. Actinobacteria belong to the genus Bifidobacterium [35].…”

Section: Introductionmentioning

confidence: 99%

Major approaches to bone regeneration process with gut microbiota, exosomes, and microRNAs: a systematic review

Sarraceni¹,

Miyazaki²,

Kassis³

2022

MedNEXT

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Introduction: The incidence and mortality of bone diseases are still steadily increasing, creating a significant financial burden for societies across the world. To prevent the occurrence of bone diseases, slow their progression, or reverse the injuries they cause, new alternatives or complementary treatments need to be developed. The gut microbiota plays a role in bone metabolism and the pathogenesis of osteoporosis. Objective: It was to analyze through a systematic review the main considerations and clinical findings of the bone formation process through the modulation of the gut microbiota, as well as the functions of microRNAs and exosomes. Methods: The systematic review rules (PRISMA) were followed. The search was carried out from August to September 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2001 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 126 articles were found. A total of 34 articles were fully evaluated and 26 were included in this systematic review. Most studies showed homogeneity in their results, with I2 =98.8%>50%. The symmetrical funnel plot does not suggest a risk of bias between small sample-size studies. The gut microbiota plays an important role in the modulation of bone healing and bone health through the traffic of inflammatory TNF+ T and Th17 cells to the bone marrow, influencing the inflammatory state of the patient, determining the “brain-gut-bone” axis. It has been shown that the diversity of the gut microbiota is decreased in patients with osteoporosis, leading to a state of dysbiosis. There is a relationship between the microbiome, osteoblasts, osteoclasts, and nuclear factor ligand receptor-kappa-B (RANKL) activator. Studies have proposed several mechanisms of gut microbiome interaction with osteoclastogenesis and bone health, including microRNA, insulin-like growth factor 1, and immune system mediation. Therefore, bone regeneration requires that the basic biological principles of osteogenesis, osteoinduction, osteoconduction, and biocompatibility are followed.

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“…They help reduce S. mutans in plaque and saliva. In combination with fluoride, their administration prevented or slowed the early demineralization of enamel [ 56 , 61 , 62 ]. In one study, a significant reduction in Aggregatibacter Actinomycetemcomitans , but not other periodontal pathogenic bacteria, occurred with probiotic administration in the oral cavity [ 63 ].…”

Section: Introductionmentioning

confidence: 99%

Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

et al. 2022

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The oral microbiota plays a vital role in the human microbiome and oral health. Imbalances between microbes and their hosts can lead to oral and systemic disorders such as diabetes or cardiovascular disease. The purpose of this review is to investigate the literature evidence of oral microbiota dysbiosis on oral health and discuss current knowledge and emerging mechanisms governing oral polymicrobial synergy and dysbiosis; both have enhanced our understanding of pathogenic mechanisms and aided the design of innovative therapeutic approaches as ORALBIOTICA for oral diseases such as demineralization. PubMed, Web of Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, APA PsyArticles, and DRUGS@FDA were searched for publications that matched our topic from January 2017 to 22 April 2022, with an English language constraint using the following Boolean keywords: (“microbio*” and “demineralization*”) AND (“oral microbiota” and “demineralization”). Twenty-two studies were included for qualitative analysis. As seen by the studies included in this review, the balance of the microbiota is unstable and influenced by oral hygiene, the presence of orthodontic devices in the oral cavity and poor eating habits that can modify its composition and behavior in both positive and negative ways, increasing the development of demineralization, caries processes, and periodontal disease. Under conditions of dysbiosis, favored by an acidic environment, the reproduction of specific bacterial strains increases, favoring cariogenic ones such as Bifidobacterium dentium, Bifidobacterium longum, and S. mutans, than S. salivarius and A. viscosus, and increasing of Firmicutes strains to the disadvantage of Bacteroidetes. Microbial balance can be restored by using probiotics and prebiotics to manage and treat oral diseases, as evidenced by mouthwashes or dietary modifications that can influence microbiota balance and prevent or slow disease progression.

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Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature

Cited by 44 publications

References 298 publications

Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast

Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast

Major approaches to bone regeneration process with gut microbiota, exosomes, and microRNAs: a systematic review

Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

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