Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination

Winter, Amy; Martinez, Micaela E; Cutts, Felicity; Moss, William J.; Ferrari, Matt J.; McKee, A.; Lessler, Justin; Hayford, Kyla; Wallinga, Jacco; Metcalf, C. Jessica E.

doi:10.1093/infdis/jiy137

Cited by 68 publications

(65 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…41 Increases in R in highly immunized populations may reflect a series of issues, including spatial heterogeneity in population immunity, 29 but studies also suggest vaccine induced measles-specific IgG antibodies decline with time since vaccination and maternally-derived immunity may wane faster if vaccine derived. [41][42][43][44] Vaccinated people may be susceptible to measles for a range of reasons, including maternallyderived antibody interference, infection before an immune response has been developed, and poor vaccine storage and handling affecting vaccine efficacy, [45][46][47] but waning immunity may increasingly play a role. 41 This poses numerous questions and requires further study, and yet supports the case for sustaining a highly immunized population.…”

Section: Disease Incidence and Transmission In Highly Immunized Populmentioning

confidence: 99%

Measles vaccination in an increasingly immunized and developed world

Hayman

2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Increased measles immunization has led to a significant decline in measles incidence and mortality. During 2016 it is estimated that fewer than 100,000 died from measles for the first time in recorded history. In highly immunized countries measles epidemiology has changed. Threats to national elimination goals and public health include aging cohorts of naïve people that exist from imperfect vaccination rates during the early years of immunization programs. This may be complemented by some loss of immunity in vaccinated populations. While childhood immunization must remain a focus for control efforts, due to higher mortality in the very young, these naïve adolescents and adults also accumulate as they age and add to the pool of susceptible people, perhaps beyond the view of those that are focused on childhood immunization. Here, features of measles epidemiology and control in highly immunized populations are reviewed, providing global data where necessary, to highlight why countries with high immunization coverage are still threatened by measles outbreaks and how changing dynamics may alter disease control.

show abstract

Section: Disease Incidence and Transmission In Highly Immunized Populmentioning

confidence: 99%

Measles vaccination in an increasingly immunized and developed world

Hayman

2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…4,5 Serum immune testing studies are useful to determine the status of both immunity and susceptibility rate against rubella and address the status of rubella elimination. 6 Before the start of rubella immunization program in Iran, the incidence of CRS is estimated to be about 0.2 per 1000 people. In December 2003, a national immunization campaign against measles and rubella was conducted in all 5 to 25 year old Iranian people.…”

Section: Introductionmentioning

confidence: 99%

Sero-epidemiological evaluation of rubella immunity among pre-marriage women in Iran

Zahraei

Mokhtari‐Azad

Sabouri

et al. 2019

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Few studies have addressed the seroepidemiological profile of rubella among a representative population of young adult women. This study aims to determine the immunity and susceptibility rate against rubella in a representative population of women in reproductive age in Iran through serological evaluation. This cross-sectional study was conducted in 2012 on 804 pre-marriage women in Iran. Multi-stage random sampling was used for choosing study sample. Serologic test were used to assess subjects' immunity to rubella and their titers of IgG antibody against rubella with Elisa method was measured. In total, 98.4% (95% CI: 97.1% -97.3%) of study participants were immune against rubella. Five women (0.6%) were in borderline category and 1% (8 women) was susceptible to rubella. The proportion of immune people in low and high incidence regions was 99.3% (95% CI: 97.8-99.9%), and 97.5% (95% CI: 95.5-95.89%), respectively (P = 0.05). Our data indicated that level of immunity to rubella in women of reproductive age in Iran is satisfactory. This finding indicates the achievement of Iran to the goal of high level of serum immunity against rubella among young women.

show abstract

“…This method has been applied in 18 countries in Europe to inform vaccine policies and measles and rubella elimination programs ( 10 , 11 ). This information can be used for evaluation of the effect and duration of protection from vaccines and for modeling and health economic evaluations of current or future vaccination programs.…”

mentioning

confidence: 99%

Plans for Nationwide Serosurveillance Network in Vietnam

Anh¹,

Choisy²,

Clapham³

et al. 2020

Emerg. Infect. Dis.

View full text Add to dashboard Cite

In recent years, serosurveillance has gained momentum as a way of determining disease transmission and immunity in populations, particularly with respect to vaccine-preventable diseases. At the end of 2017, the Oxford University Clinical Research Unit and the National Institute of Hygiene and Epidemiology held a meeting in Vietnam with national policy makers, researchers, and international experts to discuss current seroepidemiologic projects in Vietnam and future needs and plans for nationwide serosurveillance. This report summarizes the meeting and the plans that were discussed to set up nationwide serosurveillance in Vietnam.

show abstract

Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination

Abstract: We use simulations to highlight how (accounting for the dynamical context) high-quality measles and rubella serological surveys can be used to inform key control and elimination questions if the challenges of conducting, analyzing, and interpreting them are overcome.

Cited by 68 publications

References 36 publications

Measles vaccination in an increasingly immunized and developed world

Measles vaccination in an increasingly immunized and developed world

Sero-epidemiological evaluation of rubella immunity among pre-marriage women in Iran

Plans for Nationwide Serosurveillance Network in Vietnam

Contact Info

Product

Resources

About