Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction

Piao, Zhe; Jeong, Myung Ho; Li, Ying; Jin, Li; Kim, Hyun Kuk; Park, Keun-Ho; Sim, Doo Sun; Kim, Kye Hun; Hong, Young Joon; Park, Hyungwook; Kim, Ju Han; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Kim, Young Jo; Cho, Myeong Chan; Kim, Chong Jin; Kim, Hyo–Soo

doi:10.1016/j.jjcc.2015.09.013

Cited by 25 publications

(29 citation statements)

References 38 publications

(44 reference statements)

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“…Additionally, a previous randomized study has demonstrated that statin use suppresses coronary spasm [28]. The results of the present study are in agreement with the previous study [28,29] and support the efficacy and usefulness of statin therapy for coronary spasm after PCI. In this study, smoking was not a predictor of cardiac events related to coronary spasm.…”

Section: Discussionsupporting

confidence: 92%

The real-world prevalence of cardiovascular events related to coronary spasm after percutaneous coronary intervention

Hokimoto

Tabata

Sueta

et al. 2016

Journal of Cardiology

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Section: Discussionsupporting

confidence: 92%

The real-world prevalence of cardiovascular events related to coronary spasm after percutaneous coronary intervention

Hokimoto

Tabata

Sueta

et al. 2016

Journal of Cardiology

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“…AMI can be classified into acute ST-segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI). Cardiovascular disease is the most common disease in elderly and also one of the indexes reflecting the prognosis of patients with acute coronary syndrome; aging is an important risk factor of the occurrence and development of coronary heart disease 3,4. Cardiac failure is usually induced after the occurrence of AMI in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of recombinant human brain natriuretic peptide in the treatment of acute myocardial infarction in elderly in combination with cardiac failure

Wang

Meng

et al. 2017

Pak J Med Sci

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Objective:To investigate the effects and safety of recombinant human brain natriuretic peptide (rhBNP) in the treatment of elderly acute myocardial infarction induced cardiac failure.Methods:One hundred and forty-six patients who were diagnosed as elderly acute myocardial infarction induced cardiac failure in the hospital from July 2014 to July 2015 were selected. They were divided into a test group and a control group, 73 each. Patients in both groups were given conventional treatment such as stabilization of atherosclerotic plaques, anti-platelet and remodeling and reversion of myocardium. The curative effects and the incidence of adverse reactions of the two groups were observed.Results:The overall efficacy of the test group and the control group was 87.7% and 65.8% respectively, and the difference had statistical significance (P<0.05). The heart rate, urine volume, n-terminal pro-brain natriuretic peptide level and left ventricular ejection fraction (LVEF) of both groups significantly improved after treatment, and the improvement of the test group was superior to that of the control group (P<0.05). The serum creatinine of the test group remarkably reduced after treatment (P<0.05). The incidence of hypotension and arrhythmia of the test group was lower than that of the control group during hospitalization period (P<0.05).Conclusion:rhBNP can effectively relieve the clinical symptoms, cardiac function indexes and hemodynamic indexes of patients with elderly acute myocardial infarction induced cardiac failure, with a high safety. It can be extensively applied in the treatment of acute myocardial infarction in combination with cardiac failure.

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“… 50) Statin therapy for spasm-induced AMI patients improved MACE-free survival at 1-year. 51) Statin plus ezetimibe did not significantly reduce MACE compared with high-intensity statin in Korea AMI patients. 52) On subgroup analysis, however, statin plus ezetimibe was effective in high-risk patients, such as those with diabetes mellitus, old age, and low left ventricular ejection fraction (LVEF).…”

Section: Medical Treatmentmentioning

confidence: 90%

Differences in the Korea Acute Myocardial Infarction Registry Compared with Western Registries

Sim

Cho

2017

Korean Circ J

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The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide registry that reflects current therapeutic approaches and acute myocardial infarction (AMI) management in Korea. The results of the KAMIR demonstrated different risk factors and responses to medical and interventional treatments. The results indicated that the incidence of ST-elevation myocardial infarction (STEMI) was relatively high, and that the prevalence of dyslipidemia was relatively low with higher triglyceride and lower high-density lipoprotein cholesterol levels. Percutaneous coronary intervention (PCI) rates were high for both STEMI and non-ST-elevation myocardial infarction (NSTEMI) with higher use of drug-eluting stents (DESs). DES were effective and safe without increased risk of stent thrombosis in Korean AMI patients. Triple antiplatelet therapy, consisting of aspirin, clopidogrel, and cilostazol, was effective in preventing adverse clinical outcomes after PCI. Statin therapy was effective in Korean AMI patients, including those with very low levels of low-density lipoprotein cholesterol and those with cardiogenic shock. The KAMIR score had a greater predictive value than Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) scores for long-term mortality in AMI patients. Based on these results, the KAMIR will be instrumental for establishing new therapeutic strategies and effective methods for secondary prevention of AMI and guidelines for Asian patients.

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Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction

Abstract: Statin therapy in patients with coronary spasm-induced AMI with nonobstructive coronary arteries was associated with improved clinical outcome, which was predominantly accounted for by reducing the incidence of myocardial infarction.

Cited by 25 publications

References 38 publications

The real-world prevalence of cardiovascular events related to coronary spasm after percutaneous coronary intervention

The real-world prevalence of cardiovascular events related to coronary spasm after percutaneous coronary intervention

Effectiveness and safety of recombinant human brain natriuretic peptide in the treatment of acute myocardial infarction in elderly in combination with cardiac failure

Differences in the Korea Acute Myocardial Infarction Registry Compared with Western Registries

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