Beneficial role of sulfated polysaccharides from edible seaweed Fucus vesiculosus in experimental hyperoxaluria

Veena, Coothan Kandaswamy; Josephine, Anthony; Preetha, S.; Varalakshmi, P.

doi:10.1016/j.foodchem.2005.12.040

Cited by 73 publications

(41 citation statements)

References 41 publications

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“…Our results coincides with that of Veena et al (2005) who showed that the sulfated polysaccharides from edible sea weed Fucus vesiculosus restore this enzyme level in hyperoxaluric rats. Subha et al (1992) reported that administration of sodium pentosan phosphate restored the levels of this enzyme in urolithiatic rats.…”

Section: Unitssupporting

confidence: 92%

“…A predominance of men over women can be observed with an incidence peak between the fourth and fifth decade of life. Recurrent stone formation is a common part of the medical care of patients with stone disease (Tiselius et al, 2001).Urolithiasis is a recurrent renal disease affects 4-8% in UK, 15% in US, 20% in Gulf countries and 11% population in India. Stone formation tends to recur at very high rate; without preventative measures after a first stone.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Saccharum spontaneum Linn. on Lysosomal enzymes of Uro-lithiatic rats

Sathya¹

2012

J. App. Pharm. Sci.

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The ethanolic root extract of Saccharum spontaneum of family Poaceae was used to treatthe urolithiasis induced by glycolic acid On this course, the extract also repairs the changesthat happened in the lysosomal enzymes like β-D-glucuronidase, xanthine oxidase in liver and kidney and n-acetyl _-d-glucosaminidase in serum, liver, kidney and urine of the urolithiatic rats. The ethanolic root extract (200 and 300 / kg b.w.) elevated the levels of reduced β-D-glucuronidasein liver and n-acetyl _-d-glucosaminidase in liver and kidney and reduced the level of xanthineoxidase in liver and kidney and n-acetyl _-d-glucosaminidase in serum and urine significantly (p<0.05) when compared with the toxic groups. The results shown by the ethanolic root extract (200 and 300 mg / kg b.w.) was compared to standard thiazide drug treated group, showing no significantdifference (p<0.05) and thus it proves that the ethanolic root extract of S.spontaneum exhibits potent antiurolithiatic activity.

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Section: Unitssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of Saccharum spontaneum Linn. on Lysosomal enzymes of Uro-lithiatic rats

Sathya¹

2012

J. App. Pharm. Sci.

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“…L. japonica contains alginate, mannitol, laminaran, fucoidan, cellulose, protein, iodine (Podkorytova et al, 2007) and other mineral substances (Zhao et al, 2008), dibutyl phthalate (Namikoshi et al, 2006), etc. Sulfated polysaccharides in seaweed show diverse biological activities of potential medicinal value, such as anticoagulant (Nishino & Nagumo 1992), antitumor (Zhuang et al, 1995), contraceptive, antiviral (Feldman et al, 1999;Ponce et al, 2003), antioxidant (Qi et al, 2005;Tannin-Spitz et al, 2005;Wang et al, 2008), neuroprotective (Jhamandas et al, 2005), and hypolipidemic effects (Shanmugam & Mody, 2000;Veena et al, 2007). Fucoidan polysaccharide sulfuric acid ester (FPS), a group of sulfated heteropolysaccharides, extracted from L. japonica consists mainly of fucose and sulfate, with a smaller amount of arabinose and a trace of rhamnose.…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic effect of fucoidan fromLaminaria japonicain hyperlipidemic rats

Huang

Wen

Gao

et al. 2010

Pharmaceutical Biology

110

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“…These algal derived marine carbohydrate polymers present numerous valuable bioactivities (15). These sulfated polysaccharides were reported to have blood anticoagulant, anti-tumor, anti-mutagenic, antiinflammatory, antiviral, antioxidant and anticomplementary activities (18,30,39,42,48).…”

Section: Introductionmentioning

confidence: 99%

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

MERT¹

2018

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Fucoidan is a polysaccharide with high viscosity and mucilage, which contains significant proportion of sulphate ester group and L-fucose. It is present in intercellular spaces of brown algae. This study aimed to investigate the effect of fucoidan on some biochemical parameters and kidney tissues in nephrotoxicity induced by GM in rats. The rats used in the study were randomly divided into 4 groups. Each group had 7 rats as control, fucoidan, GM and GM+fucoidan. Blood samples were taken after 24 hours from the end of experiment which lasted eight days. Creatinine, BUN, uric acid, glucose, triglycerides, total cholesterol, VLDL, HDL, total bilirubin levels and ALT, AST, ALP, LDH, CK, amylase activities were assayed by an autoanalyser. The kidney tissues were examined histopathologically. In GM+fucoidan group, creatinine (p<0.001), BUN (p<0.001), uric acid (p<0.05), triglycerides (p<0.05), VLDL (p<0.05), AST (p<0.001), ALP (p<0.05), LDH (p<0.001), CK (p<0.01) levels statistically decreased, however HDL (p<0.05) level increased when compared to GM group. As conclusion, it can be said that administering fucoidan during GM toxicity decreases the nephrotoxicity damage. Considering biochemical parameters and histopathological findings, fucoidan can be suggested as a protective agent for kidneys in nephrotoxicity induced rats.

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Beneficial role of sulfated polysaccharides from edible seaweed Fucus vesiculosus in experimental hyperoxaluria

Cited by 73 publications

References 41 publications

Effect of Saccharum spontaneum Linn. on Lysosomal enzymes of Uro-lithiatic rats

Effect of Saccharum spontaneum Linn. on Lysosomal enzymes of Uro-lithiatic rats

Hypolipidemic effect of fucoidan fromLaminaria japonicain hyperlipidemic rats

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

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