Hypolipidemic effect of fucoidan from<i>Laminaria japonica</i>in hyperlipidemic rats

Huang, Ling; Wen, Kewei; Gao, Xuan; Liu, Yonghong

doi:10.3109/13880200903150435

Cited by 110 publications

(70 citation statements)

References 22 publications

(23 reference statements)

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“…In particular, GGEx18 has already been used as an anti-obesity drug in local clinics of Korea, although the mechanism of its action remains unknown. These three herbs are reported to have antiobesity, anti-diabetes, and lipid-lowering effects (Boozer et al, 2001(Boozer et al, , 2002Huang et al, 2010;Xue et al, 2010;You et al, 2009;Zheng et al, 2010), supporting the belief that GGEx18 may regulate obesity and its related metabolic disorders. These reports led to the speculation of whether high fat diet-induced obesity in mice can be regulated more efficiently when treated with a mixture of the above three herbal extracts (GGEx18) at the same time.…”

Section: Research Articlementioning

confidence: 80%

The herbal composition GGEx18 fromLaminaria japonica, Rheum palmatum, andEphedra sinicareduces obesity via skeletal muscle AMPK and PPARα

Shin

Park

Lee

et al. 2011

Pharmaceutical Biology

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Section: Research Articlementioning

confidence: 80%

The herbal composition GGEx18 fromLaminaria japonica, Rheum palmatum, andEphedra sinicareduces obesity via skeletal muscle AMPK and PPARα

Shin

Park

Lee

et al. 2011

Pharmaceutical Biology

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“…Huang et al (20) reported that fucoidan polysaccharide sulfuric acid ester from Laminaria japonica Aresch (Laminariaceae) notably reduced the concentration of serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol of hyperlipidemic rats and increased the concentration of high-density lipoprotein cholesterol and the activities of lipoprotein lipase, hepatic lipoprotein, and lecithin cholesterol acyltransferase (LCAT). Park et al (28) also found that fucoidan can be useful for the prevention or treatment of obesity due to its stimulatory lipolysis.…”

Section: Discussionmentioning

confidence: 99%

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

MERT¹

2018

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Fucoidan is a polysaccharide with high viscosity and mucilage, which contains significant proportion of sulphate ester group and L-fucose. It is present in intercellular spaces of brown algae. This study aimed to investigate the effect of fucoidan on some biochemical parameters and kidney tissues in nephrotoxicity induced by GM in rats. The rats used in the study were randomly divided into 4 groups. Each group had 7 rats as control, fucoidan, GM and GM+fucoidan. Blood samples were taken after 24 hours from the end of experiment which lasted eight days. Creatinine, BUN, uric acid, glucose, triglycerides, total cholesterol, VLDL, HDL, total bilirubin levels and ALT, AST, ALP, LDH, CK, amylase activities were assayed by an autoanalyser. The kidney tissues were examined histopathologically. In GM+fucoidan group, creatinine (p<0.001), BUN (p<0.001), uric acid (p<0.05), triglycerides (p<0.05), VLDL (p<0.05), AST (p<0.001), ALP (p<0.05), LDH (p<0.001), CK (p<0.01) levels statistically decreased, however HDL (p<0.05) level increased when compared to GM group. As conclusion, it can be said that administering fucoidan during GM toxicity decreases the nephrotoxicity damage. Considering biochemical parameters and histopathological findings, fucoidan can be suggested as a protective agent for kidneys in nephrotoxicity induced rats.

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“…Fucoidan from L. japonica reduced serum total and LDL-cholesterol and triglycerides and raised HDL-cholesterol in a hyperlipidemic rat model [69]. Fucoidan treatment led to less severe symptoms in the early stages of Staphylococcus aureus triggered arthritis in mice, but delayed phagocyte recruitment and decreased clearance of the bacterium [70].…”

Section: Biological Aspects Of Fucoidanmentioning

confidence: 96%

Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

Kalimuthu

Kim

2014

Handbook of Anticancer Drugs From Marine Origin

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Cancer is most common in worldwide and badly threaten to human's life. Unfortunately drugs, which are used for cancer therapy, are toxic and affect not only cancer cells but also normal cells and tissues. At last decade marine brown algae attract much attention because they represent a rich and easily regenerated source of polysaccharides with various structures and biological activities. Fucoidan sulfated polysaccharides (FCSPs) extracted from seaweeds, mainly brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, the mechanism of cell death depends on the magnitude of DNA damage following exposure to anticancer agents. Apoptosis is mainly regulated by cell growth signaling molecules. Fucoidan was shown to induce cytotoxicity of various cancer cells, induces apoptosis, and inhibits invasion, metastasis and angiogenesis of cancer cells. Hence, this chapter deals the potential role of fucoidan on cancer therapeutics.

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Hypolipidemic effect of fucoidan fromLaminaria japonicain hyperlipidemic rats

Cited by 110 publications

References 22 publications

The herbal composition GGEx18 fromLaminaria japonica, Rheum palmatum, andEphedra sinicareduces obesity via skeletal muscle AMPK and PPARα

The herbal composition GGEx18 fromLaminaria japonica, Rheum palmatum, andEphedra sinicareduces obesity via skeletal muscle AMPK and PPARα

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

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