Beneficial effects of zinc supplementation on head circumference of Nepalese infants and toddlers: a randomized controlled trial

Surkan, Pamela J.; Shankar, Manjunath; Katz, Joanne; Siegel, Emily H.; LeClerq, Steven C.; Khatry, Subarna K.; Stoltzfus, Rebecca J.; Tielsch, James M.

doi:10.1038/ejcn.2012.42

Cited by 14 publications

(9 citation statements)

References 45 publications

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“…Zinc has been reported to have functional properties such as antioxidant, anti-inflammatory and antiapoptotic effects with its immunoregulator effects on animals and humans (Costa et al, 2012), Especially, the prenatal zinc supplementation confers a beneficial effect on the infants' neurobehavioural development and immune functions, or the rate of head growth in infants (Surkan et al, 2012). However there is concern that nano-sized materials exhibit unknown biological or environmental effects, even if their bulk counterparts are known to be safe (Yoshida et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Exposure to zinc oxide nanoparticles affects reproductive development and biodistribution in offspring rats

Seo

Kwon

et al. 2013

J. Toxicol. Sci.

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-Understanding reproductive development effects and transferable properties to next generation of zinc oxide nanoparticles is necessary for prevention of its potential risks. To accomplish this, rats were exposed to zinc oxide nanomaterials (500 mg/kg bw) of less than 100 nm beginning 2 weeks before mating to postnatal day 4. In addition, body distribution of zinc concentration was evaluated in dams and offspring. Rat treated with nano-zinc oxide showed reduced number of born/live pups, decreased body weights of pups and increased fetal resorption. Zinc oxide nanomaterials were also distributed to organs such as mammary tissue of dams and liver and kidney of pups. These results indicate that zinc oxide nanoparticles-exposure before and during pregnancy and lactation could pose health risks to pregnant women and their fetus.

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Section: Discussionmentioning

confidence: 99%

Exposure to zinc oxide nanoparticles affects reproductive development and biodistribution in offspring rats

Seo

Kwon

et al. 2013

J. Toxicol. Sci.

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“…In a RCT conducted by Tielsch et al, 2007 in central Nepal, mean(SD) values of Zn were 11.0 (2.1) μmol/L in placebo and 11.8 (2.4) μmol/L in Zn supplemented children respectively [1]. Supplementation trials of Zn in pneumonia [5,6], and other diseases affecting mortality [1], anthropometry [7,8] and socio-demographic variables [9,10] have been conducted in Nepalese populations in the past decade. Prevalence and the burden of Zn deficiency in the eastern part of Nepal are yet to be explored.…”

Section: Introductionmentioning

confidence: 99%

Plasma zinc levels, anthropometric and socio-demographic characteristics of school children in eastern Nepal

et al. 2014

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BackgroundZinc deficiency is a major public health problem in many developing countries including Nepal. The present study was designed to assess the prevalence of zinc deficiency and to study the association of zinc deficiency with anthropometric and socio-demographic variables, in school children of eastern Nepal.MethodsThis cross-sectional study included total 125 school children of age group 6–12 years from Sunsari and Dhankuta districts of eastern Nepal. Plasma zinc level was estimated by Flame Atomic Absorption Spectroscopy.ResultsThe Median interquartile range (IQR) values of zinc in the two districts Sunsari and Dhankuta were 5.9 (4.4, 7.9) μmol/L and 5.8 (4.3, 8.4) μmol/L respectively. A total of 55 children (87.3%) in Sunsari and 52 (83.9%) in Dhankuta had zinc deficiency, no significant difference was observed in the Median (IQR) plasma zinc levels (p = 0.9) and zinc deficiency patterns (p = 0.3) of the two districts. Significant differences were observed in the plasma zinc levels (p = 0.02) and zinc deficiency patterns (p = 0.001), of the school children having age groups 6–8 years than in 9–10 and 11–12 years of age, and zinc deficiency patterns between male and female school children (p = 0.04) respectively.ConclusionsThe present study showed higher prevalence of zinc deficiency among school children in eastern Nepal. In our study, zinc deficiency was associated with both sex and age. The findings from the present study will help to populate data for policy implementation regarding consumption and supplementation of zinc.

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“…Also comes in agreement with Sur et al [22] who found in their study significant effect of zinc supplementation on weight, length and linear growth velocity at the end of 1 year only . Also Surkan PJ, et al [23] who considered as a fact that preventive zinc supplementation in populations at risk of zinc deficiency increases linear growth and weight gain among infants and young children and Hoque et al [24] in a study of 200 LBW infants also found significant effect of Zn supplementation on weight gain. However, authors did not study the effect of Zn on other growth parameters.…”

Section: Results:-mentioning

confidence: 99%

The Effect of Zinc Supplementation on Growth and Development in Preterm Neonates.

Elsadek¹,

ElFaiky²,

Behiry³

et al. 2016

IJAR

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Objective: This study aimed to show the effect of zinc supplementation on growth and development in preterm neonates in the first 4 months of life. Background: Preterm infants have impaired zinc status because of low body stores as 60% of fetal zinc is acquired during the third trimester of pregnancy in addition to their limied capacity to absorp and retain micronutrients, coupled with increased endogenous losses associated with organ immaturity. Subjects and methods: The present study was carried out at Pediatric and Clinical Pathology departemets, Benha University hospital, in the period between March 2015 to Septemper 2015. on 80 healthy preterm infants between 32 and 36 weeks of age divided into two groups : zinc-supplemented group fed with breast milk, and supplemented with multivitamins and zinc (2 mg/kg/day) since the first day of life, and a non-zinc-supplemented group fed breast milk with multivitamins only (without zinc supplementation). Both groups were followed for 4 months for growth with assessment of development by the Age and Stage Questionnaire at 4 months of corrected age and serum levels of zinc at 2 and 4 months and hemoglobin at 4 months were measured. Results: In our study , it was found that the zinc-supplemented group had a significantly higher increase in weight and length at 2 and 4 months of chronological age (p < 0.001) , and non significant increase in head circumference at 2 and 4 months of chronological age (p > 0.05) compared with the non-zinc-supplemented group. Also our study found that the zinc supplemented group had significantly higher weight, length centiles (p < 0.001) and significant increase in head circumference centile (p < 0.05) than that of the non-zincsupplemented group. There was a highly significant increase in the serum zinc levels of the zinc-supplemented group at 2 and 4 months (p <0.001) compared with the non-zinc-supplemented group, in addition the zinc supplemented group had significantly higher level of HB at 4 months (p< 0.001) than that of non zinc supplemented group. Also, the developmental score of the zinc-supplemented group was

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Beneficial effects of zinc supplementation on head circumference of Nepalese infants and toddlers: a randomized controlled trial

Cited by 14 publications

References 45 publications

Exposure to zinc oxide nanoparticles affects reproductive development and biodistribution in offspring rats

Exposure to zinc oxide nanoparticles affects reproductive development and biodistribution in offspring rats

Plasma zinc levels, anthropometric and socio-demographic characteristics of school children in eastern Nepal

The Effect of Zinc Supplementation on Growth and Development in Preterm Neonates.

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