Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: Critical role of striatal catalase activity

Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms

“…The results confirm our recent report of the efficacy of EGb761 in lowering TD severity in schizophrenia patients [38]. They are also consistent with the findings of most previous studies using various antioxidants for treatment of TD in humans and animal models, such as VE [27][28][29][30][45][46][47], vitamin B6, quercetin, melatonin [41,[48][49][50][51][52], and piracetam [53].…”

Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function

“…We cannot discard the possibility that the protective effect exerted by vitamin C and E supplementation could be due to other actions beyond the antioxidant effects of both vitamins, such as inhibition of pro-inflammatory cytokine release (Fisher et al 2004). However, the straight relationship observed between exercise-induced brain oxidative stress and the impairment of cognitive function, on one hand, and the significant recovery of cognitive function and the reduced level of brain oxidative stress in exercised, but supplemented animals, on the other hand, strongly argue in favor of the importance of the antioxidant features of the vitamins C and E. Finally, it should be stressed that according to Faria et al (2005), the simultaneous treatment with both vitamin C and E was more efficient to attenuate reserpine-induced oral dyskinesia, which is known to be associated with brain oxidative stress, than supplementation with either one of these vitamins.…”

“…Supplemented animal groups were simultaneously supplemented with 10 mg/kg vitamin E and 10 mg/kg vitamin C (Faria et al 2005), once a day and 2 h before the beginning of the exercise session. The vitamin supplementation was administered intraperitoneally, in volumes not exceeding 1 ml/kg body wt.…”

Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors

“…Previous studies described no changes in oxidative stress parameters after administration of reserpine in brain areas related to motor functions, such as cerebral cortex and striatum [7,13,14]. However, these findings conflict with other published results that suggest the involvement of oxidative stress in reserpine-induced motor disturbance [6,71].…”