Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms

An, Hee-Jung; Tan, Yun Long; Wang, Zhi Ren; Li, Jia; Wang, Yue Chan; Lv, Meng; Zhou, Dong; Soares, Jair C.; Kosten, Thomas; Yang, Fu De; Zhang, Xiang Yang

doi:10.1016/j.bbr.2015.10.004

Cited by 5 publications

(4 citation statements)

References 52 publications

(76 reference statements)

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“…With long-term use, haloperidol causes neurotoxic effects, and the most likely cause of this phenomenon is oxidative stress, which can lead to cognitive dysfunction and motor impairments such as haloperidol-induced tardive dyskinesia [ 25 , 98 , 99 , 100 ]. It has been shown that, in addition to increasing oxidative stress, haloperidol can reduce the level of autophagy in SH-SY5Y cells and rat neurons, but the mechanism of this phenomenon is not clear [ 25 , 26 ].…”

Section: Effect Of Different Compounds On Mitophagymentioning

confidence: 99%

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Makarov

Korkotian

2023

Toxins

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Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication of nerve cells and decreased plasticity, which is associated with a loss of cognitive functions and neurodegeneration. Maintaining proper synaptic activity depends on the qualitative composition of mitochondria, because synaptic processes require sufficient energy supply and fine calcium regulation. The maintenance of the qualitative composition of mitochondria occurs due to mitophagy. The regulation of mitophagy is usually based on several internal mechanisms, as well as on signals and substances coming from outside the cell. These substances may directly or indirectly enhance or weaken mitophagy. In this review, we have considered the role of some compounds in process of mitophagy and neurodegeneration. Some of them have a beneficial effect on the functions of mitochondria and enhance mitophagy, showing promise as novel drugs for the treatment of neurodegenerative pathologies, while others contribute to a decrease in mitophagy.

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Section: Effect Of Different Compounds On Mitophagymentioning

confidence: 99%

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Makarov

Korkotian

2023

Toxins

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“…On the contrary, IL-10 is decreased, due to its role as an anti-inflammatory cytokine ( Peroza et al, 2016 ; Sonego et al, 2018 ). Consequently, some agents with antioxidative and anti-inflammatory properties were tested as potential drugs for TD, such as resveratrol ( Busanello et al, 2012 , Busanello et al, 2017 ), vitamin E ( An et al, 2016 ; Shi et al, 2016 ), lycopene ( Datta et al, 2016 ), L-theanine ( Chen et al, 2018 ; Soung et al, 2018 ; Tsai et al, 2019 ), cannabidiol ( Sonego et al, 2018 ; Kajero et al, 2020 ), and catechin ( Wang et al, 2015 ; Reinheimer et al, 2020 ). Additionally, several different plant-based compounds were tested ( Patil et al, 2012 ; Sekiguchi et al, 2012 ; An et al, 2013 ; An et al, 2016 ; Shi et al, 2016 ; Samad and Haleem 2017 ; Dhingra et al, 2018 ; Wang et al, 2021a ).…”

Section: Preclinical Studies Of Tardive Dyskinesia Developmentmentioning

confidence: 99%

“…Caspase-3 was elevated in animals with TD ( Bishnoi and Boparai 2012 ; Soung et al, 2018 ; Wang et al, 2021a ). Furthermore, the transcription level of the proapoptotic BAX was elevated, whereas antiapoptotic BAD mRNA was decreased ( An et al, 2016 ). In light of this brain-derived neurotrophic factor (BDNF), a molecule involved in the viability of neurons, was shown to be decreased in several brain regions of rats with haloperidol-induced VCM.…”

Section: Preclinical Studies Of Tardive Dyskinesia Developmentmentioning

confidence: 99%

“…On the other hand, higher concentrations induce neurodegeneration and apoptosis. A rat model of TD showed increased levels of S100B, which were rescued by antioxidant administration ( An et al, 2016 ). A study conducted by Miksys et al dealt with brain metabolism levels of haloperidol and their association with TD development in a rat model.…”

Section: Preclinical Studies Of Tardive Dyskinesia Developmentmentioning

confidence: 99%

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Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies

2022

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Tardive dyskinesia is a severe motor adverse event of antipsychotic medication, characterized by involuntary athetoid movements of the trunk, limbs, and/or orofacial areas. It affects two to ten patients under long-term administration of antipsychotics that do not subside for years even after the drug is stopped. Dopamine, serotonin, cannabinoid receptors, oxidative stress, plasticity factors, signaling cascades, as well as CYP isoenzymes and transporters have been associated with tardive dyskinesia (TD) occurrence in terms of genetic variability and metabolic capacity. Besides the factors related to the drug and the dose and patients’ clinical characteristics, a very crucial variable of TD development is individual susceptibility and genetic predisposition. This review summarizes the studies in experimental animal models and clinical studies focusing on the impact of genetic variations on TD occurrence. We identified eight genes emerging from preclinical findings that also reached statistical significance in at least one clinical study. The results of clinical studies are often conflicting and non-conclusive enough to support implementation in clinical practice.

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Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats

Samad

Haleem

2017

Metab Brain Dis

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Tardive dyskinesia (TD) is associated with the use of antipsychotic drugs such as D2 antagonist haloperidol (HP). The chronic use of HP is involved in the causation of free radicals and/or oxidative stress. In view of the nootropic, anti-anxiety, anti-inflammatory-like effects of rice bran oil (RBO) in a variety of investigations, we assessed the protective properties of RBO on HP-induced TD and neurochemical alteration. Rats treated with HP orally at a dose of 0.2 mg/kg/day for a period of 5 weeks developed VCMs which increased progressively as the treatment continued for 5 weeks. Co-administration of RBO by oral tubes at a dose of 0.4 ml/day prevented the induction of HP-induced VCMs. Repeated administration of HP increases the turnover of dopamine metabolism in the striatum. Conversely animals treated with HP + RBO decrease the metabolism of DA than water + HP treated animals. Striatal, malondieldehyde (MDA), hydrogen peroxide (HO) and antioxidant enzyme superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were also determined. It is suggested that beneficial role of RBO in attenuation of HP-induced TD. The results therefore recommended that supplementation of RBO may be useful in the HP-induced TD. The findings have also potential implication in the treatment of schizophrenia and motor disorders.

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Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms

Cited by 5 publications

References 52 publications

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies

Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats

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