Beneficial effects of polyunsaturated fatty acids in partially nephrectomized rats

Barcelli, Uno; Miyata, Jun; Ito, Yasushi; Gallon, Lois S.; Laskarzewski, Peter M.; Weiss, Mark A.; Hitzemann, Robert; Pollak, Victor E.

doi:10.1016/0090-6980(86)90126-7

Cited by 49 publications

(14 citation statements)

References 12 publications

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“…In the model of subtotal renal abla tion, Scharschmidt et al [48] found that rats supple mented with menhaden oil had a greater decline in renal function, and a greater degree of glomerulosclerosis than did animals fed beef tallow. Other authors, however, have noted beneficial effects of fish oils in the remnant kidney model [49], It has been suggested that the differences in results could be seconday to the toxicity of oxidized fish oil in the former study [50], as an antioxidant used by Barcelli was not used in the Scharschmidt study.…”

Section: Omega-3 Fatty Acid (Fish Oil) Supplementationmentioning

confidence: 93%

Relationship between Hyperlipidemia, Lipid Mediators, and Progressive Glomerulosclerosis in the Nephrotic Syndrome

Kees-Folts

Diamond

1993

Am J Nephrol

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Nephrotic syndrome is defined by proteinuria, hypoalbuminemia, edema and hypercholesterolemia. Evidence from both the experimental and clinical literature suggests that high lipid levels are not only a marker of disease, but also contribute to the process of glomerulosclerosis. Lipid mediators, including eicosanoids, platelet-activating factor, and chemotactic factors, can contribute by effecting leukocyte infiltration, mesangial proliferation, extracellular matrix protein production, vasoreactivity, and coagulation. Infiltrating macrophages may play a central role in these processes. Therapeutic maneuvers aimed at the correction of lipid abnormalities may halt or slow the progression of nephrotic syndrome to end-stage renal disease.

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Section: Omega-3 Fatty Acid (Fish Oil) Supplementationmentioning

confidence: 93%

Relationship between Hyperlipidemia, Lipid Mediators, and Progressive Glomerulosclerosis in the Nephrotic Syndrome

Kees-Folts

Diamond

1993

Am J Nephrol

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“…Those of the n-6 series are (23) whereas those of the n-3 series exert their main effect on triglycerides and their effect on lipoproteins has been questioned (33). It has also been suggested that PUFAs improve renal lesions not by reducing the serum levels of lipoproteins, but by modifying lipoprotein composition, their deposition within the glomeruli or the cholesterol or ester composition in the tissues (20,(34)(35)(36). A marked increase in proteinuria was observed in both CRF groups, suggesting that glomerular selectivity was compromised to the same extent in both groups.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, they showed better levels of arterial pressure and proteinuria. It has been suggested that PUFAs of the n-6 series may reduce the deterioration of renal function and the glomerular sclerosis of rats with CRF (20,21,30). Conversely, Brown et al (38) found that in dogs with CRF, supplementation with omega 6 PUFA enhanced renal injury, and supplementation with omega 3 was renoprotective.…”

Section: Discussionmentioning

confidence: 99%

“…Subtotally nephrectomized rats fed a low linoleic acid diet had progressive deterioration of renal function. By contrast, those fed the high linoleic acid diet had better preservation of renal function with less proteinuria and glomerular sclerosis (20,21), and also an increase in the renal content of arachidonic acid (22). Other investigators have shown that rats with CRF fed a linoleic acid-enriched diet had an increase in proteinuria and glomerular sclerosis index (GSI), and also a worsened progression of CRF (23).…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary linoleic acid on the progression of chronic renal failure in rats

Gregório

Lemos

Caldas

et al. 2002

Braz J Med Biol Res

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The role of linoleic acid in chronic renal failure (CRF) is controversial. In the present study 21 male Wistar rats submitted to 5/6 renal mass reduction (R) and 16 normal controls (C) were fed a supplement (S) or normal (N) linoleic acid diet for 60 days starting 10 days after CRF. As expected, serum creatinine, cholesterol and triglycerides (mean ± SEM) were higher in the CRF groups compared to the C groups (P<0.05). The RS group presented lower cholesterol (84 ± 4 vs 126 ± 13 mg%) and triglyceride (88 ± 9 vs 132 ± 19 mg%) levels compared to the RN group. Proteinuria and kidney weight did not differ between CRF groups. Glomerular area increased 78% in RS and 100% in RN compared to control rats. Glomerular sclerosis index tended to be lower in RS (27%) compared to RN (38%), tubulointerstitial damage was similar between CRF groups (RS = 1.91 ± 0.2 and RN = 2.14 ± 0.3), and mesangial fractional volume increased to the same extent in both CRF groups. The data suggest that a linoleic acid-enriched diet did not protect against the progression of CRF after 60 days.

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“…Nevertheless, most experiments studying kidney lesions have been performed either in animals with a genetic susceptibility to develop a kidney disease or in animals with a preexisting kidney disease like diabetes, hypertension or subtotal nephrectomy [18]. The aims of this study were two: (1) to establish whether a hypercholesterolaemic diet, alone or in association with unilateral nephrectomy, can induce the appearance of FGS; and (2) to determine whether treatment with omega-3 polyunsaturated fatty acids (PUFA) can reduce this glomerular injury. We have also examined the effects of hypercholesterolaemia and omega-3 PUFA on the pattern of urinary PG in an attempt to correlate it with renal injury.…”

Section: Introductionmentioning

confidence: 99%

Effects of polyunsaturated fatty acids on rat glomerulosclerosis induced by hypercholesterolaemic diet

et al. 1998

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Association between lipids and renal disease has been reported recently. Its pathogenic mechanisms remain unknown. The aims of this study were to establish: (1) if a cholesterol-rich diet, alone or associated with nephrectomy, produces nephropathy; and (2) if a treatment with omega-3 polyunsaturated fatty acids (PUFA) reduces glomerulosclerotic lesions. Sixty Sprague-Dawley rats were randomized in two different groups: (A) sham operated rats and (B) uninephrectomized rats. Rats in both groups were divided into three subgroups (A1-3, B1-3) according to the diet they were fed: normal chow diet, cholesterol-rich diet (4.5%) or cholesterol-rich diet supplemented with omega-3 PUFA. Twenty weeks later, serum creatinine, creatinine clearance, serum cholesterol, triglycerides, albumin, proteinuria, mesangial cell score and focal glomerulosclerosis were assessed. Results showed that a cholesterol-rich diet significantly increased serum cholesterol, proteinuria and glomerular lesions and decreased creatinine clearance, especially in nephrectomized rats. Glomerular lesions, serum cholesterol and proteinuria ameliorated when cholesterol-rich diet was supplemented with PUFA. Hypertension was noticed only in nephrectomized rats following a normal chow diet. Simple correlation analysis showed that glomerulosclerosis correlated with renal weight, blood creatinine, cholesterol and proteinuria. In spite of some significant differences in urinary prostaglandins, no correlation with glomerular lesions was found. Multiple logistic regression analysis showed that cholesterol and proteinuria were independent risk factors for induction of glomerular sclerosis. In conclusion, a diet rich in cholesterol induces glomerulosclerosis, especially if it is associated with unilateral nephrectomy. Omega-3 PUFA administration reduces serum cholesterol, proteinuria and glomerular injury.

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Beneficial effects of polyunsaturated fatty acids in partially nephrectomized rats

Cited by 49 publications

References 12 publications

Relationship between Hyperlipidemia, Lipid Mediators, and Progressive Glomerulosclerosis in the Nephrotic Syndrome

Relationship between Hyperlipidemia, Lipid Mediators, and Progressive Glomerulosclerosis in the Nephrotic Syndrome

Effect of dietary linoleic acid on the progression of chronic renal failure in rats

Effects of polyunsaturated fatty acids on rat glomerulosclerosis induced by hypercholesterolaemic diet

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