2008
DOI: 10.5483/bmbrep.2008.41.10.710
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Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats

Abstract: This study investigated the effect of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into normal control (NC), diabetic control (DC), and diabetic treatment with Phellodendri Cortex extract (DP). Over a 4-week experimental period, Phellodendri Cortex extract was administered orally at 379 mg/kg BW/day. The final fasting serum glucose level, urine total protein level, and relative left kidney weight in the DP g… Show more

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Cited by 46 publications
(29 citation statements)
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“…These findings of present study are in agreement with the findings of Ramesh et al, Kim et al (2008) and Renno et al (2008) who showed tubular epithelial changes, enlargement of lining cells of tubules and accumulation of glycogen in the kidney tubules. Glycogen accumulation in the renal tubules could be attributed to hyperglycaemia induced by streptozotocin-induced diabetes.…”
Section: Discussionsupporting
confidence: 83%
“…These findings of present study are in agreement with the findings of Ramesh et al, Kim et al (2008) and Renno et al (2008) who showed tubular epithelial changes, enlargement of lining cells of tubules and accumulation of glycogen in the kidney tubules. Glycogen accumulation in the renal tubules could be attributed to hyperglycaemia induced by streptozotocin-induced diabetes.…”
Section: Discussionsupporting
confidence: 83%
“…[15] Interestingly, anti-diabetic properties of non-polar Toona sinensis Roem (Meliaceae) extract [16] and leaf extract contains the hypoglycemia effect underlying an increment of insulin to regulate the adipose glucose transporter 4 (GLUT4) have been reported. [17] Cortex Phellodendri can reduce glucose level and prevent or retard the development of diabetic nephropathy in streptozotocin-induced diabetic rats [18] and reveals the potential alpha-glucosidase and xanthine oxidase inhibitors. [19] Curcumin is the yellow-colored bioactive constituent of the perennial plant, Curcuma longa L., which possesses a wide range of physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective and anti-diabetic activities.…”
Section: Introductionmentioning
confidence: 99%
“…The development of diabetic nephropathy is stimulated by prolonged hyperglycemia [3,4,5,6] and the disease has distinct phases of development. Early alterations include glomerular and tubular epithelial hypertrophy, glomerular hyperfiltration, and development of microalbuminuria.…”
Section: Introductionmentioning
confidence: 99%