Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats

Kim, Hyejeong; Kong, Min-kyu; Kim, Young‐Chul

doi:10.5483/bmbrep.2008.41.10.710

Cited by 46 publications

(29 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings of present study are in agreement with the findings of Ramesh et al, Kim et al (2008) and Renno et al (2008) who showed tubular epithelial changes, enlargement of lining cells of tubules and accumulation of glycogen in the kidney tubules. Glycogen accumulation in the renal tubules could be attributed to hyperglycaemia induced by streptozotocin-induced diabetes.…”

Section: Discussionsupporting

confidence: 83%

Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

Zafar¹,

Naqvi²,

Ahmed³

et al. 2009

Int. J. Morphol.

View full text Add to dashboard Cite

SUMMARY:We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology, anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) in albino rats. The aim of the study was to investigate the association between diabetic kidney complications and kidney enzyme alterations. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians & Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty (80) albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. Histopathology of kidney showed lesions similar to human glomerulosclerosis, glomerular membrane thickening, arteriolar hyalinization and tubular necrosis. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) were observed in the kidney. It seems that the diabetic complications in the kidney are likely to be associated with alterations in enzyme levels.

show abstract

Section: Discussionsupporting

confidence: 83%

Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

Zafar¹,

Naqvi²,

Ahmed³

et al. 2009

Int. J. Morphol.

View full text Add to dashboard Cite

show abstract

“…[15] Interestingly, anti-diabetic properties of non-polar Toona sinensis Roem (Meliaceae) extract [16] and leaf extract contains the hypoglycemia effect underlying an increment of insulin to regulate the adipose glucose transporter 4 (GLUT4) have been reported. [17] Cortex Phellodendri can reduce glucose level and prevent or retard the development of diabetic nephropathy in streptozotocin-induced diabetic rats [18] and reveals the potential alpha-glucosidase and xanthine oxidase inhibitors. [19] Curcumin is the yellow-colored bioactive constituent of the perennial plant, Curcuma longa L., which possesses a wide range of physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective and anti-diabetic activities.…”

Section: Introductionmentioning

confidence: 99%

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia <em>in Vitro </em>and <em>in Vivo</em>

Riyaphan¹,

Jhong²,

Tsai³

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…The development of diabetic nephropathy is stimulated by prolonged hyperglycemia [3,4,5,6] and the disease has distinct phases of development. Early alterations include glomerular and tubular epithelial hypertrophy, glomerular hyperfiltration, and development of microalbuminuria.…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow-Derived Mononuclear Cells Promote Improvement in Glomerular Function in Rats with Early Diabetic Nephropathy

Castiglione

Maron‐Gutierrez

Barbosa

et al. 2013

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Diabetic nephropathy is one of the main causes of end-stage renal disease. The present study investigated the effect of mononuclear cell (MC) therapy in rats subjected to diabetic nephropathy. Methods: Male Wistar rats were divided into control (CTRL), diabetic (DM), CTRL+MC and DM+MC groups. Diabetes was induced by a single injection of streptozotocin (45 mg/kg, i.p.) and, 4 weeks later, 2×10⁷ MCs were injected via the jugular vein. Results: The rats in the DM and DM+MC groups showed increased glycemia, glomerular filtration rate and glomerular tuff area versus control groups. The glomerular filtration rate and glomerular tuff area were normalized in the DM+MC group. No alterations were observed in the fractional excretion of electrolytes and proteinuria between the DM and DM+MC groups. TGF-β1 protein levels in the DM group were significantly increased versus control animals and normalized in the DM+MC group. An increase in ED1⁺/arginase I⁺ macrophages and IL-10 renal expression was observed in the DM+MC group versus DM group. Conclusions: Bone marrow-derived MC therapy was able to prevent glomerular alterations and TGF-β1 protein overexpression and modulated glomerular arginase I⁺ macrophage infiltration in rats subjected to early diabetic nephropathy.

show abstract

Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats

Cited by 46 publications

References 21 publications

Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia <em>in Vitro </em>and <em>in Vivo</em>

Bone Marrow-Derived Mononuclear Cells Promote Improvement in Glomerular Function in Rats with Early Diabetic Nephropathy

Contact Info

Product

Resources

About