Beneficial effects of pentoxifylline and propentofylline on the warm ischemic injury of rat livers

Iwamoto, Hiroshi; Kozaki, Koichi; Nakamura, Nishio; Hama, Kazuaki; Narumi, Katsuya; Matsuno, N; Kuzuoka, K.; Taira, S.; Kihara, Yasuki; Uchiyama, M; Takeuchi, Hiroto; Nagao, Toshiyuki

doi:10.1016/s0041-1345(02)03372-9

Cited by 8 publications

(4 citation statements)

References 2 publications

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“…PTX (Torental®, Hoechst, Paris, France) was suspended in Ringer lactate solution to a concentration of 50 mg/kg (0.75 ml) as described previously in other studies 8 , 16 , 17 .…”

Section: Methodsmentioning

confidence: 99%

“…Pentoxifylline (PTX) is a methylxanthine phosphodiesterase inhibitor commonly used to treat peripheral vascular diseases 5 . PTX has been shown to improve survival rate after normothermic liver I‐R 6–8 and hepatocellular function after hemorrhagic trauma and resuscitation 9 . Blockage of TNFα release from KCs by PTX prevents up‐regulation of TNFα expression after normothermic I‐R 10 .…”

Section: Introductionmentioning

confidence: 99%

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Pentoxifylline inhibits liver expression of tumor necrosis factor alpha mRNA following normothermic ischemia-reperfusion

El-Ghoneimi

Cursio

Schmid-Alliana

et al. 2007

HPB

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“…PTX (Torental®, Hoechst, Paris, France) was suspended in Ringer lactate solution to a concentration of 50 mg/kg (0.75 ml) as described previously in other studies 8 , 16 , 17 .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pentoxifylline inhibits liver expression of tumor necrosis factor alpha mRNA following normothermic ischemia-reperfusion

El-Ghoneimi

Cursio

Schmid-Alliana

et al. 2007

HPB

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“…The protective effects of pentoxifylline on ischemic injuries in the lung, intestine, liver, and kidney have been demonstrated [ 18 - 20 ]. Many interventions have been investigated for the treatment of perinatal hypoxic-ischemic brain damage.…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline Alleviates Perinatal Hypoxic-Ischemia-Induced Short-term Memory Impairment by Suppressing Apoptosis in the Hippocampus of Rat Pups

et al. 2016

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Purpose:Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurologic morbidity in infants and children. We investigated the effects of pentoxifylline, a methylxanthine derivative and type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal cell death in the hippocampus following perinatal hypoxic-ischemia in newborn rats.Methods:We used a step-down avoidance task to evaluate short-term memory and 3ʹ-5ʹ-cyclic adenosine monophosphate (cAMP) assay to detect cAMP levels. We evaluated apoptosis using a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for evidence of DNA fragmentation, immunohistochemistry for caspase-3 levels, and western blot for Bcl-2 and Bax.Results:Perinatal hypoxic-ischemic injury increased apoptotic cell death in the hippocampus, resulting in impaired short-term memory with decreased cAMP levels. Pentoxifylline treatment improved short-term memory by suppressing apoptotic cell death in the hippocampus with elevated cAMP levels.Conclusions:Pentoxifylline ameliorated perinatal hypoxic-ischemia in rat pups. This alleviating effect could be ascribed to the inhibition apoptosis due to increased cAMP production by pentoxifylline.

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“…Studies of the anti-inflammatory effects of PTX in vivo have focused attention on tissue injury after ischemia. Thus, in vivo PTX treatment reduced ischemia-reperfusion injury in the lung (Thabut et al, 2001), intestine (Sener et al, 2001), liver (Iwamoto et al, 2002), kidney (Kim et al, 2001), spinal cord (Savas et al, 2002), and brain of different animal species including rats, mice, and dogs (Toung et al, 1994;Sirin et al, 1998;Eun et al, 2000). Inflammatory processes accompany tissue injury regardless of the organ system involved, and chronic inflammation may predispose to ischemia in peripheral organs and to brain damage (Lindsberg and Grau, 2003).…”

mentioning

confidence: 99%

Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats

Banfi¹,

Sironi²,

Simoni³

et al. 2004

J Pharmacol Exp Ther

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Anti-inflammatory properties of pentoxifylline (PTX) have recently been described. Spontaneously hypertensive strokeprone rats (SHRSP) constitute an animal model that develops an inflammatory condition that precedes the appearance of brain abnormalities. The aim of the present investigation was to assess: 1) the efficacy of PTX treatment in protecting the neural system in SHRSP, and 2) how its anti-inflammatory properties might be involved in this effect. Male SHRSP fed with a permissive diet received no drug or PTX (100 or 200 mg/kg/day). Brain abnormalities detected by magnetic resonance imaging developed spontaneously in control rats after 42 Ϯ 3 days, whereas in rats treated with 100 mg/kg/day PTX, abnormalities developed in only 80% of the animals and only after 70 to 80 days. Treatment with a higher dose of PTX (200 mg/kg/day) completely protected the brain from abnormal development.

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Beneficial effects of pentoxifylline and propentofylline on the warm ischemic injury of rat livers

Cited by 8 publications

References 2 publications

Pentoxifylline inhibits liver expression of tumor necrosis factor alpha mRNA following normothermic ischemia-reperfusion

Pentoxifylline inhibits liver expression of tumor necrosis factor alpha mRNA following normothermic ischemia-reperfusion

Pentoxifylline Alleviates Perinatal Hypoxic-Ischemia-Induced Short-term Memory Impairment by Suppressing Apoptosis in the Hippocampus of Rat Pups

Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats

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