Beneficial Effects of n-3 Polyunsaturated Fatty Acids on Offspring’s Pancreas of Gestational Diabetes Rats

Gao, Jinlong; Huang, Tao; Li, Jiaomei; Guo, Xiaofei; Xiao, Hailong; Gu, Jiang; Tang, Jun; Cai, Wei; Li, Duo

doi:10.1021/acs.jafc.9b05739

Cited by 9 publications

(7 citation statements)

References 71 publications

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“…Of these associated metabolites, elevated stearoyl carnitine has been reported in the pancreas of gestational diabetes mellitus offspring, indicating altered fatty acid oxidation in the pancreas. 35 Through the glutaminase II pathway, alpha-ketoglutaramate links glutamine to the tricarboxylic acid (TCA) cycle, contributing to glutamine addiction. A previous study revealed that pancreatic cancer cells utilize the glutaminase II pathway as an alternative when glutaminase I pathway is inhibited, which converts glutamine into alpha-ketoglutaramate, then glutamate.…”

Section: Discussionmentioning

confidence: 99%

“…Of them, 44 metabolites showed significant associations with PDAC risk when using instruments derived from one of the cohorts, which warrants further validation from independent studies. Of these associated metabolites, elevated stearoyl carnitine has been reported in the pancreas of gestational diabetes mellitus offspring, indicating altered fatty acid oxidation in the pancreas 35 . Through the glutaminase II pathway, alpha‐ketoglutaramate links glutamine to the tricarboxylic acid (TCA) cycle, contributing to glutamine addiction.…”

Section: Discussionmentioning

confidence: 99%

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Elucidating the role of blood metabolites on pancreatic cancer risk using two‐sample Mendelian randomization analysis

Zhong,

Liu,

Zhu

et al. 2023

Intl Journal of Cancer

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Pancreatic ductal adenocarcinoma (PDAC) is an uncommon but highly fatal malignancy. Identifying causal metabolite biomarkers offers an opportunity to facilitate effective risk assessment strategies for PDAC. In this study, we performed a two‐sample Mendelian randomization (MR) study to characterize the potential causal effects of metabolites in plasma on PDAC risk. Genetic instruments were determined for a total of 506 metabolites from one set of comprehensive genome‐wide association studies (GWAS) involving 913 individuals of European ancestry from the INTERVAL/EPIC‐Norfolk cohorts. Another set of genetic instruments was developed for 483 metabolites from an independent GWAS conducted with 8299 individuals of European ancestry from the Canadian Longitudinal Study on Aging (CLSA) cohort. We analyzed GWAS data of the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case‐Control Consortium (PanC4), comprising 8275 PDAC cases and 6723 controls of European ancestry. The association of metabolites with PDAC risk was assessed using the inverse‐variance weighted (IVW) method, and complemented with sensitivity analyses of MR‐Egger and MR‐PRESSO tests. Potential side effects of targeting the identified metabolites for PDAC intervention were further evaluated by a phenome‐wide MR (Phe‐MR) analysis. Forty‐four unique metabolites were identified to be significantly associated with PDAC risk, of which four top‐ranking metabolites (X: 12798, X: 11787, X: 11308 and X: 19141) showed replication evidence when using instruments developed from both two cohorts. Our results highlight novel blood metabolites related to PDAC risk, which may help prioritize metabolic features for PDAC mechanistic research and further evaluation of their potential role in PDAC risk assessment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elucidating the role of blood metabolites on pancreatic cancer risk using two‐sample Mendelian randomization analysis

Zhong,

Liu,

Zhu

et al. 2023

Intl Journal of Cancer

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“…Co-supplementation of omega-3 fatty acids (at a dose of 1 g per day) and vitamin E for 6 weeks in 60 women with GDM did not improve insulin resistance or lipids but improved plasma total antioxidant capacity plasma malondialdehyde, and nitric oxide (54). A study of the long-term influence of GDM and the effect of omega-3 polyunsaturated fatty acids on the pancreas of the offspring found that supplementation lowered the pancreatic oxidative stress and inflammation, as evident by pancreatic fatty infiltration (55).…”

Section: Fish Oils and Fatty Acids Supplementationmentioning

confidence: 99%

The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control

et al. 2022

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The nutritional state before and throughout pregnancy has a critical impact on the women's health and the baby's development and growth. The release of placental hormones during pregnancy induces/ increases maternal insulin resistance and promotes nutrition utilization by the fetus. Gestational Diabetes Mellitus (GDM) is the most common medical complication in pregnancy and is associated with significant maternal and fetal morbidity. Several studies have examined the effect of physical activity, healthy eating, and various food supplements on the risk of developing gestational diabetes (GDM) and related outcomes. Among those, Myo-Inositol supplementation has shown encouraging results in the prevention of GDM. Maternal vitamin D deficiency has been associated with an elevated risk of GDM, and supplementation can improve glucose haemostasis by lowering fasting blood glucose, HbA1c, and serum insulin concentration. Probiotics modulate the gut microbiota leading to an improved glucose and lipid metabolism, which is proposed to reduce the risk of GDM. We aim to review the strength and limitation of the current evidence for using some nutritional supplements either as single agents or in combinations on the risk of developing GDM and on glycaemic control.

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“…Animal models have suggested that n-3 PUFAs may reduce the secretion of inflammatory cytokines and reverse glucose intolerance [ 67 , 68 ]. Meanwhile, n-3 PUFAs can also improve pancreatic fatty infiltration in the offspring of GDM mice [ 69 ]. Therefore, DHA may also have some preventive and therapeutic effects on GDM.…”

Section: Gestational Diabetes Mellitus (Gdm)mentioning

confidence: 99%

DHA supplementation and pregnancy complications

et al. 2023

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Docosahexaenoic acid (DHA) supplementation is recommended for women during pregnancy because of its neurological, visual, and cognitive effects. Previous studies have suggested that DHA supplementation during pregnancy may prevent and treat certain pregnancy complications. However, there are contradictions in the current related studies, and the specific mechanism by which DHA acts remains unclear. This review summarizes the research on the relationship between DHA intake during pregnancy and preeclampsia, gestational diabetes mellitus, preterm birth, intrauterine growth restriction, and postpartum depression. Furthermore, we explore the impact of DHA intake during pregnancy on the prediction, prevention, and treatment of pregnancy complications as well as its impact on offspring neurodevelopment. Our results suggest that there is limited and controversial evidence for the protective effect of DHA intake on pregnancy complications, with the exception of preterm birth and gestational diabetes mellitus. However, additional DHA supplementation may improve long-term neurodevelopmental outcomes in the offspring of women with pregnancy complications.

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Beneficial Effects of n-3 Polyunsaturated Fatty Acids on Offspring’s Pancreas of Gestational Diabetes Rats

Cited by 9 publications

References 71 publications

Elucidating the role of blood metabolites on pancreatic cancer risk using two‐sample Mendelian randomization analysis

Elucidating the role of blood metabolites on pancreatic cancer risk using two‐sample Mendelian randomization analysis

The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control

DHA supplementation and pregnancy complications

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