The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control

Ibrahim, Ibrahim; Bashir, Mohammed; Singh, Parul; Khodor, Souhaila Al; Abdullahi, Hala

doi:10.3389/fnut.2022.867099

Cited by 4 publications

(4 citation statements)

References 95 publications

(91 reference statements)

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“…Because the baby needs vitamins to continue its development in a healthy way. In particular, deficiencies of important micronutrients such as iron, iodine, folic acid, vitamin D and vitamin B12 cause various diseases such as megaloblastia, neural tube defects, placental and fetal defects (9). In particular, it was determined that the iron mineral was very low in individuals with GDM compared to healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Nutritional Status with Serum Vitamin D and B12 Levels in Pregnant Women with Gestational Diabetes

Celenk

Çebi

2023

Middle Black Sea Journal of Health Science

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Abstract Objective: In this study, it was aimed to evaluate the nutritional adequacy status of pregnant women with gestational diabetes and to examine the relationship between biochemical parameters such as vitamin D, vitamin B12, hemoglobin, hematocrit and fasting glucose. Materials and Method: In the study, serum vitamin D and B12 levels of 130 pregnant women between 24-28 weeks of gestation were examined. As a result of 75 gram oral glucose tolerance test, 70 pregnant women were diagnosed with gestational diabetes mellitus (GDM). The control group consisted of 60 healthy pregnant women. Nutritional factors were obtained through a questionnaire (anthropometric measurements, micronutrients, 3-day food consumption frequency, use of vitamin supplements) and groups were compared in terms of biochemical parameters (vitamin D, vitamin B12). Results: Pregnant women with GDM; mean age (30.34 ± 5.28), family history of diabetes (17.1%), pre-pregnancy body mass index percentage (54.3%), rate of skipping meals were higher. The rate of use of vitamin and mineral supplements in pregnant women with GDM was low. According to the analysis of 3-day food consumption records of pregnant women with GDM, it was determined that the intake of micronutrients vitamin D and vitamin B12 was insufficient. Biochemical parameters such as vitamin D, vitamin B12, hemoglobin and hematocrit were found to be lower in pregnant women with GDM. Conclusion: GDM is the most common endocrinological disorder in pregnancy. The study showed that inadequate nutrient intake negatively affects blood glucose levels and biochemical findings. Individuals with GDM should be referred to a nutritionist, medical nutrition therapy (TBT) appropriate for their individual characteristics should be given and monitored.

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Section: Discussionmentioning

confidence: 99%

Comparison of Nutritional Status with Serum Vitamin D and B12 Levels in Pregnant Women with Gestational Diabetes

Celenk

Çebi

2023

Middle Black Sea Journal of Health Science

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“…Omega‐3 is also safe during pregnancy and has multiple potential benefits, including reducing insulin resistance, preterm delivery and low birthweight. In women with GDM, the benefits of omega‐3 on lipids and glucose parameters were seen in studies that used doses of greater than or equal to 4 g/day 90 . A recent RCT 91 showed that 8 g omega‐3 in combination with vitamin D significantly reduced TG, glucose and indices of insulin resistance.…”

Section: Management Optionsmentioning

confidence: 99%

“…In women with GDM, the benefits of omega-3 on lipids and glucose parameters were seen in studies that used doses of greater than or equal to 4 g/day. 90 A recent RCT 91 showed that 8 g omega-3 in combination with vitamin D significantly reduced TG, glucose and indices of insulin resistance. Hence, it is our practice to use omega-3 in a 4 g/day dose in women with persistently elevated TG levels after lifestyle intervention.…”

Section: Omega-3mentioning

confidence: 99%

Hyperlipidaemia and severe hypertriglyceridaemia in pregnancy

Bashir

Navti

Ahmed

et al. 2023

The Obstetric & Gynaecologis

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Lipid and triglyceride levels increase in pregnancy and do not pose problems for most women. However, pregnancy-specific factors and genetic aberrations, especially mutations, may result in supraphysiological hypercholesterolaemia (HC) and severe hypertriglyceridaemia (sHTG). HC and sHTG are associated with complications in pregnancy, including acute pancreatitis, hyperviscosity syndrome and pre-eclampsia. Abnormally high levels of lipids and triglycerides also affect fetal growth and the onset of gestational diabetes. The clinical presentation and diagnosis of HC and sHTG are varied. Management options include lifestyle and dietary restriction/ modification, omega-3, bile-acid sequestrants, fenofibrate, statins and plasmapheresis. Learning objectivesTo understand the physiological changes that occur in lipids in pregnancy and how these are modulated. To appreciate the importance of severe HC and HTG in pregnancy, including their effects on maternal morbidity and mortality. To understand the various approaches to management and the importance of multidisciplinary management. Ethical issuesShould every woman be screened for HTG and HC during pregnancy? How safe are statins and other treatments for lipid disorders in pregnancy? Should women with very severe HTG be discouraged from getting pregnant?

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“… 5 , 6 Several risk factors for GDM have been identified, such as previous GDM, obesity, and polycystic ovary syndrome. 5 Although maternal nutritional status has also been linked to GDM, 7 the relationship between vitamin A and GDM is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Serum Vitamin A Levels in Early Pregnancy and the Risk of Gestational Diabetes Mellitus

Yu,

Liu,

2024

DMSO

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Background The relationship between vitamin A levels and gestational diabetes mellitus (GDM) is not well understood, and prospective studies are lacking. Methods This was a prospective, longitudinal study. A total of 391 women in early pregnancy were recruited between October and December 2018 at Shunyi District Maternal and Child Health Hospital (Beijing, China). Serum vitamin A concentration was measured at enrollment. GDM was diagnosed on the basis of a 75 g oral glucose-tolerance test at 24–28 weeks of follow-up. Logistic regression was used for the analysis. Results None of the subjects in the cohort had vitamin A deficiency or excess. At the follow-up, 76 participants had developed GDM. Participants who developed GDM were older and had higher body mass index, fasting insulin, HbA 1c , fasting glucose, homeostasis model assessment for insulin resistance, triglyceride, low-density lipoprotein cholesterol , and high-sensitivity CRP levels, as well as higher serum vitamin A levels at baseline. On logistic multivariate analysis, higher vitamin A was positively associated with higher risk of GDM. The adjusted OR was 2.85 (95% CI 1.04–7.80, P =0.042) for Q4 versus Q1 and 1.59 (95% CI 1.11–2.28, P =0.011) for every 1 SD increase in serum vitamin A levels. In participants within the vitamin A reference range (0.33–0.78 mg/L), the positive association also maintained significance. Conclusion Higher serum vitamin A levels were associated with higher GDM risks, even within the reference range. The results and possible mechanisms need to be further verified and clarified.

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The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control

Cited by 4 publications

References 95 publications

Comparison of Nutritional Status with Serum Vitamin D and B12 Levels in Pregnant Women with Gestational Diabetes

Comparison of Nutritional Status with Serum Vitamin D and B12 Levels in Pregnant Women with Gestational Diabetes

Hyperlipidaemia and severe hypertriglyceridaemia in pregnancy

Associations Between Serum Vitamin A Levels in Early Pregnancy and the Risk of Gestational Diabetes Mellitus

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