Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury

Liu, Wenhu; Liu, Te-chung; Yin, Mei‐chin

doi:10.1016/j.fct.2007.12.013

Cited by 88 publications

(66 citation statements)

References 23 publications

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“…Such effect cannot be detected when histidine is given after induction of liver fibrosis, which can be explained on the basis that oxidative stress histidine antioxidant capacities. These results are in accordance with the findings of Liu et al [37], who concluded that histidine could elevate the activity of catalase and glutathione peroxidase (GPX), as well as enhance the mRNA expression of catalase and suppress CYP2E1 activity, which causes ROS overproduction. These findings indicated that histidine may aid in an enzymatic reaction and possessed antioxidant activities, which definitely contributed to the hepatic antioxidant protection.…”

Section: Discussionsupporting

confidence: 95%

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

El-Batch

Ibrahim

Said

2010

J Biochem & Molecular Tox

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The aim of this study was to explain whether serum autotaxin (ATX) activity might be a target for regulation of liver fibrosis and to evaluate the hepatoprotective and antifibrotic effects of histidine in thioacetamide (TAA)-induced liver fibrosis in rats. This study was carried out on 100 Wistar Albino rats, classified into five groups, each containing 20 rats: Group I (control group), Group II: rats were given histidine intraperitoneally, Group III: rats were injected intraperitoneally with TAA, Group IV: rats were injected with L-histidine together with TAA, and Group V: rats were injected with TAA for 1 month then treated with intraperitoneal injection of L-histidine for another month. At the end of experiment, blood and liver were collected for determination of some liver enzymes, plasma total antioxidant capacity (TAC), serum ATX activity, and liver tissue hydroxyproline. Thioacetamide treatment caused significant increases in liver enzymes, ATX activities, and liver hydroxyproline, but a significant decrease in plasma's TAC. Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis. C 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:143-150, 2011; View this article online at wileyonlinelibrary.com.

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Section: Discussionsupporting

confidence: 95%

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

El-Batch

Ibrahim

Said

2010

J Biochem & Molecular Tox

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“…Carnosine was shown protective effect on diabetes (7), antioxidant effect (pre and post consecutive doses of carnosine) on a single i.p. cisplatin-induced nephrotoxicity in mice (8) and curative effect on hypercholesterolemia-induced kidney insult (9). Protective effects of carnosine supplement was also reported previously on chronic alchoholic and thioacetamide induced oxidative stress and hepatotoxicity (10).…”

Section: Introductionmentioning

confidence: 69%

Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Noori

Mahboob

2010

Indian J Clin Biochem

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“…It inhibits lipid peroxidation and protein oxidation and prevents advanced glycation product formation (Hipkiss 2000;Aldini et al 2005;Boldyrev 2005). Therefore, it has been proposed that carnosine may be an effective agent to prevent oxidative stress-induced pathologies such as ischemia-reperfusion (Stvolinsky and Dobrota 2000;Dobrota et al 2005;Fouad et al 2007), thioacetamide-and alcohol-induced liver damage Liu et al 2008), atherosclerosis (Rashid et al 2007), diabetic complications (Lee et al 2005), aging (Hipkiss 2006) and Alzheimer's disease (Hipkiss 2007). Carnosine levels have been reported to decrease in some tissues of aged rats (Stuerenburg and Kunze 1999) and senescence accelerated mice (Boldyrev et al 2001).…”

Section: Introductionmentioning

confidence: 97%

The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats

et al. 2009

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Carnosine (beta-alanyl-L: -histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process. This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats. At the initiation of study, young and aged rats were 5 and 22 months old, respectively. Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats. At the end of this period, malondialdehyde (MDA) and diene conjugate (DC) and protein carbonyl (PC) levels, glutathione (GSH), vitamin E and vitamin C levels and Cu,Zn-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined in tissues of carnosine-treated young and old rats. Liver and heart, but not brain MDA and DC levels increased significantly in aged rats as compared to young rats. Liver PC levels were also significantly elevated. Significant decreases in GSH and vitamin C levels and SOD activities were detected in liver of aged rats, but vitamin E levels and GSH-Px and GST activities remained unchanged. Non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats. Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats. There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats. In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver.

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Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury

Cited by 88 publications

References 23 publications

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats

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