Beneficial effects of dietary restriction in aging brain

Hadem, Ibanylla Kynjai Hynniewta; Majaw, Teikur; Kharbuli, B.; Sharma, Ramesh

doi:10.1016/j.jchemneu.2017.10.001

Cited by 42 publications

(26 citation statements)

References 185 publications

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“…Recently, there are growing reports regarding the beneficial effects of DR on many parameters of wellbeing, including life span, cognitive abilities, and neurodegeneration (Brownlow et al 2014; Hadem et al 2019; Speakman and Mitchell 2011). Moreover, CR was found protective in conditions of brain injury (Loncarevic-Vasiljkovic et al 2016; Mychasiuk et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

et al. 2019

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Traumatic brain injury (TBI) is one of the most common causes of neurological damage in young people. It was previously reported that dietary restriction, by either intermittent fasting (IF) or daily caloric restriction (CR), could protect neurons against dysfunction and degeneration in animal models of stroke and Parkinson’s disease. Recently, several studies have shown that the protein Sirtuin 1 (SIRT1) plays a significant role in the induced neuroprotection following dietary restriction. In the present study, we found a significant reduction of SIRT1 levels in the cortex and hippocampus in a mouse model of mild weight-drop closed head TBI. This reduction was prevented in mice maintained on IF (alternate day fasting) and CR initiated after the head trauma. Hippocampus-dependent learning and memory (measured using a novel object recognition test) was impaired 30 days post-injury in mice fed ad libitum, but not in mice in the IF and CR groups. These results suggest a clinical potential for IF and/or CR as an intervention to reduce brain damage and improve functional outcome in TBI patients.

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Section: Discussionmentioning

confidence: 99%

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

et al. 2019

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“…Aging is accompanied with increased oxidative stress and production of reactive oxygen species (ROS), mainly from dysfunctional mitochondria (Balaban et al 2005). Different brain regions are not equally vulnerable to oxidative damage by ROS (Hadem et al 2017). DR is anticipated to lessen the age-related increase in oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging

et al. 2018

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Albeit aging is an inevitable process, the rate of aging is susceptible to modifications. Dietary restriction (DR) is a vigorous nongenetic and nonpharmacological intervention that is known to delay aging and increase healthspan in diverse species. This study aimed to compare the impact of different restricting feeding regimes such as limited daily feeding (LDF, 60% AL) and intermittent feeding (IF) on brain energy homeostasis during aging. The analysis was focused on the key molecules in glucose and cholesterol metabolism in the cortex and hippocampus of middle-aged (12-month-old) and aged (24-month-old) male Wistar rats. We measured the impact of different DRs on the expression levels of AMPK, glucose transporters (GLUT1, GLUT3, GLUT4), and the rate-limiting enzyme in the cholesterol synthesis pathway (HMGCR). Additionally, we assessed the changes in the amounts of cholesterol, its metabolite, and precursors following LDF and IF. IF decreased the levels of AMPK and pAMPK in the cortex while the increased levels were detected in the hippocampus. Glucose metabolism was more affected in the cortex, while cholesterol metabolism was more influenced in the hippocampus. Overall, the hippocampus was more resilient to the DRs, with fewer changes compared to the cortex. We showed that LDF and IF differently affected the brain energy homeostasis during aging and that specific brain regions exhibited distinct vulnerabilities towards DRs. Consequently, special attention should be paid to the DR application among elderly as different phases of aging do not respond equally to altered nutritional regimes.

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“…The ketogenic diet [86,87] and medium-chain triglycerides (MCTs) are also recommended [87]. Further recommendations include exercise [88][89][90], stress reduction, fasting [91,92], cognitive stimulation and sleep hygiene [67].…”

Section: The Logic Of Applying Personalised Medicine To Cognitive Decmentioning

confidence: 99%

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Chalfont¹,

Simpson²,

Davies³

et al. 2019

obm geriatr

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The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a 'personalised medicine' approach challenges this view. This paper reviews the current evidence for dementia prevention utilising such treatments and explains the logic of applying personalised medicine. The functional medicine treatment approach to 'root cause' analysis is presented as currently practiced with patients experiencing cognitive decline. We report six case reports including in-depth practitioner evaluations, recommendations and follow-ups. We cover the various presentations of memory and concentration problems and the screening process with advanced functional testing. The case reports appear in a table, followed by 11 key points, insights and findings. To our knowledge, this is the first paper reporting practitioner case reports documenting improvements in symptoms of memory

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Beneficial effects of dietary restriction in aging brain

Cited by 42 publications

References 185 publications

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

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