Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model

Çağın, Yasir Furkan; Atayan, Yahya; Şahin, Nurhan; Parlakpınar, Hakan; Polat, Alaadin; Vardı, Nigar; Tağluk, M. Emin; Tanbek, Kevser; Yıldız, Azibe

doi:10.3109/10715762.2015.1126834

Cited by 19 publications

(22 citation statements)

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“…Cisplatin (Cis), whose antineoplastic efficacy was discovered in 1960s, is a platinum-derivative antineoplastic agent used to treat a variety of solid organ tumors such as testis, ovaries, urinary bladder, head and neck, brain, and lungs ( 1 – 5 ). Despite its potent antineoplastic efficacy, Cis's toxic side effects during treatment such as nephrotoxicity, neurotoxicity, ototoxicity, myelosuppression, hepatotoxicity limits its clinical use ( 1 – 5 ). Studies investigating the relationship between Cis dose and toxic side effects have mostly suggested a correlation between Cis's cumulative dose and toxic side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Studies investigating the relationship between Cis dose and toxic side effects have mostly suggested a correlation between Cis's cumulative dose and toxic side effects. This is particularly prominent for the liver and hematopoietic system ( 1 – 6 ). However, it has been shown that hepatotoxicity may also develop after a single dose or low repeated doses ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

et al. 2018

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The aim of the present study was to investigate the protective effect of dexpanthenol (Dexp) against cisplatin (Cis)-induced hepatotoxicity. Thirty-two Sprague Dawley rats were divided into four groups: Control group (n=8), Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp), Cis group (n=8, 7 mg/kg/ip/single dose Cis) and Cis+Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp +7 mg/kg/ip/single dose Cis). MDA, CAT, GSH, GSH-Px, TOS, TAS, OSI, Total Nitrit, IL-1β, IL-6 and TNF-α levels were analyzed in liver tissue samples. After paraffinization of liver tissue samples, histopathological (congestion, loss of glycogen, number of Kupffer cells) and immunohistochemical (caspase-3 expression) parameters were assessed on the paraffinized liver sections. GSH, TAS, TOS, OSI, Tot Nit, L-Arginine, ADMA and SDMA levels were measured in the serum samples. Statistically significant differences were found between the groups in terms of all liver tissue biochemical parameters, with the exception of IL-1β and TNF-α levels. GSH, CAT, GSH-Px, TAS and Tot Nit levels were significantly higher in the Cis+Dexp group compared to the Cis group, whereas MDA, TOS, OSI and IL-6 levels were higher in the Cis group. Similarly, serum GSH, TAS, Tot Nit levels were higher in the Cis+Dexp group whereas TOS, L-Arginine, ADMA and SDMA levels were higher in Cis group. There were statistically significant differences between Control and Cis groups in terms of congestion increase, increase of glycogen loss, increase of Kupffer cell number and increase of caspase-3 expression (P<0.001). There was a statistically significant difference between the Cis and the Cis+Dexp groups in terms of histopathologic parameters, with the exception of congestion (P<0.001). To conclude, histopathological, immunohistochemical, and biochemical results of this study demonstrated that Dexp has a protective effect against Cis-induced hepatotoxicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

et al. 2018

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“…After emulsi cation, the particles of fat droplets in the nutrient are reduced, thereby improving the ability of digestive enzymes in the intestine; the intestinal epithelial villi also came in contact with nutrients to promote digestion and absorption of nutrients [32,33]. At the same time, the content of (R)-pantothenic acid decreased, indicating that the synthesis of CoA increased and the amount of the intermediate, acetyl-CoA, also increased [34][35][36]. This indicated that the metabolism of the 3 major nutrients returned to normal and improved the nutritional status of the model rats [37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Assessment of Fractions of Hawthorn on Gastrointestinal Motility Disorder by UPLC-MS/MS-based Metabolomics

Wang

Luo

et al. 2020

Preprint

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Background: Hawthorn, a commonly-used traditional Chinese medicine (TCM) for treating dyspepsia，dysmenorrhea and hyperlipidemia, etc., has been proven to improve gastrointestinal motility, avoid food retention. Due to its complex ingredients, the active fractions responsible for the treatment of improving digestion remain largely unknown. To explore the underlying material and interpret its potential mechanism, the therapeutic effect of extract from different polar parts of hawthorn on gastrointestinal motility disorder was studied based on the ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) metabolomics . Materials and Methods: The rat model of gastrointestinal motility disorder was established by subcutaneous injecting with atropine. The modeled rats were then treated with 4 polar parts (T1-4 in descending polarity, corresponding to water, n-butanol, ethyl acetate and petroleum ether extracts, respectively) of hawthorn for 5 consecutive days. The stomach, small intestine, plasma samples were collected and then subjected to related measurement (gastric emptying rate and small intestine propulsion rate), UPLC-MS/MS metabolic profiling and multivariate/univariate statistical analysis. Results: The results showed that T3 had the best therapeutic effect, and T1, T2 and T4 with no obvious therapeutic effect, demonstrating that the effective components of hawthorn should be compounds of medium polarity. T3 achieved good therapeutic effects due to the gastrointestinal motility promotion activity, and by rectifying the disturbed amino acid metabolism in gastrointestinal motility disorder model. Conclusion: This integrated metabolomics approach proved the validity of the therapeutic effect of extract from different polar parts of hawthorn on gastrointestinal motility disorder, providing new insights into the underlying mechanisms, and demonstrating the feasibility of metabolomics to evaluate efficacy of herbal drug, which is often difficult by traditional means.

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“…Tissue hypoxia results in movement of neutrophils and macrophages into the interstitium through the action of hypoxia adaptive pathways [104][105][106]. Activated neutrophils subsequently release molecular mediators, which contribute to the production of adenosine on the vascular endothelial surface, a protective factor that restores endothelial integrity [107,108].…”

Section: Ischemia: Reperfusion Injurymentioning

confidence: 99%

Acute Arterial Embolism of the Lower Limb

Casas¹

2020

Embolic Diseases - Evolving Diagnostic and Management Approaches

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Despite advances in the management of peripheral arterial occlusive disease, acute embolism of the lower extremities is still characterized by an important limb threat, morbidity, mortality, and continues to pose a challenge to the vascular surgeon. Atrial fibrillation, left ventricular aneurysm, penetrating ulcers or aneurysms of the aorta and common iliac arteries are the common sources of emboli. The presence of occlusion can be determined noninvasively with the use of duplex Doppler ultrasonography. Arteriography, Computed Tomographic Angiography and Magnetic Resonance Angiography can also be employed. Embolectomy is the standard for acute leg ischemia in patients with a strong clinical suspicion of an embolus, but alternative techniques, such as catheter-directed thrombolysis or percutaneous aspiration thrombolectomy, expand the role of radiologic percutaneous therapy of the acutely ischemic limb.The arteries most commonly affected in the lower limbs are the femoral, the popliteal, the iliac, and the aorta [9][10][11][12][13]. The most frequent site of involvement is the femoral bifurcation, accounting for 35-50% of cases [14][15][16][17].The approach of the arterial embolism of the lower limb has evolved significantly in the past decade, especially regarding the development of endovascular treatment. EtiologyThe heart has been described as a source of emboli with frequency in the range of 78-96% [12,18]. When emboli originate in the heart, more than 70% will obstruct the lower limbs, including those lodged at the bifurcation of the aorta [19]. The majority of emboli originate in the heart, primarily the left heart, as a result of fragmentation of intracavitary thrombi [15,16].Atrial fibrillation, left ventricular aneurysm, penetrating ulcers or aneurysms of the aorta and common iliac arteries are the common sources of emboli. Nearly all emboli arise from the left heart, aorta, and iliac vessels. A minority are paradoxical venous emboli that pass through an intracardiac shunt. Emboli typically lodge at branch points in the vascular tree and occlude both tributaries [20]. The most frequent cause of formation of these thrombi is atrial fibrillation, which occurs in mitral valve lesions of rheumatic origin, hyperthyroidism, acute myocardial infarction, and cardiosclerosis. The hemodynamic changes caused by atrial fibrillation, causing formation of mural thrombi, is the most important source of emboli [16,21].

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Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model

Abstract: Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.

Cited by 19 publications

References 33 publications

Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

Therapeutic Assessment of Fractions of Hawthorn on Gastrointestinal Motility Disorder by UPLC-MS/MS-based Metabolomics

Acute Arterial Embolism of the Lower Limb

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