Beneficial effects of consumption of acerola, cashew or guava processing by-products on intestinal health and lipid metabolism in dyslipidaemic female Wistar rats

Abstract

This study assessed the effects of diet supplementation with industrial processing by-products of acerola (Malpighia emarginata D.C.), cashew (Anacardium occidentale L.) and guava (Psidium guajava L.) fruit on the intestinal health and lipid metabolism of female Wistar rats with diet-induced dyslipidaemia. Female rats were randomly divided into five groups: healthy control, dyslipidaemic control and dyslipidaemic experimental receiving acerola, cashew or guava processing by-products. Fruit processing by-products were administered (400 mg/kg body weight) via orogastric administration for 28 consecutive days. Acerola, cashew and guava by-products caused body weight reduction (3·42, 3·08 and 5·20 %, respectively) in dyslipidaemic female rats. Dyslipidaemic female rats receiving fruit by-products, especially from acerola, presented decreased faecal pH, visceral fat, liver fat and serum lipid levels, as well as increased faecal moisture, faecal fat excretion, faecal Bifidobacterium spp. and Lactobacillus spp. counts and amounts of organic acids in faeces. Administration of the tested fruit processing by-products protected colon and liver from tissue damage (e.g. destruction of liver and colon cells and increased fat deposition in hepatocytes) induced by dyslipidaemic diet. Dietary fibres and phenolic compounds in tested fruit by-products may be associated with these positive effects. The industrial fruit processing by-products studied, mainly from acerola, exert functional properties that could enable their use to protect the harmful effects on intestinal health and lipid metabolism caused by dyslipidaemic diet.

Maternal dyslipidaemic diet induces sex-specific alterations in intestinal function and lipid metabolism in rat offspring

“…layer were evaluated in intestinal histological sections (15) . Inflammatory exudate, hyperaemia, haemorrhage, necrosis, preservation of the hepatic parenchyma (cell integrity, centralised nuclei and highly evident nucleoli) and degenerative processes (e.g.…”

“…Inflammatory exudate, hyperaemia, haemorrhage, necrosis, preservation of the hepatic parenchyma (cell integrity, centralised nuclei and highly evident nucleoli) and degenerative processes (e.g. fat degeneration) were evaluated in liver histological sections (15) . Quantitative analyses of the intestinal morphometry of animals were also performed.…”

“…Although the modulation of gut microbiota in newborns has been believed to occur through breast-feeding and the inclusion of other foods in the post-weaning diet, there has been strong evidence indicating that the gut colonisation of infants may have already occurred before birth (10)(11)(12) . Dyslipidaemia may promote intestinal villi wear and in the long-term, alterations in gut microbiota composition (13)(14)(15) . Populations of Enterococcus spp., Lactobacillus spp.…”

Protective Effects of Tropical Fruit Processing Coproducts on Probiotic Lactobacillus Strains during Freeze-Drying and Storage

“…These fruit processing coproducts consist mainly of peels, seeds, and some mashed flesh, which are considered sources of compounds with different beneficial biological activities [5]. The consumption of acerola, cashew, and guava agroindustrial coproducts was reported to cause no damage to the histopathological characteristics of intestine and liver of rats, indicating the low potential toxicity of these materials [6].…”

FIA– Spectrophotometric methods for the determination of Naringenin in supplements and urine samples using diazotization coupling reactions

“…This constituent can be found in fruits, vegetables, and beverages. It has various ranges of biological functions such as antioxidant, blood lipid-lowering, anti-inflammatory and anti-carcinogenic [1][2][3][4][5]. NG has been determined using…”