Beneficial Effects of Citrus Juice Fermented with Lactobacillus plantarum YIT 0132 on Japanese Cedar Pollinosis

Abstract

Recently, the prevalence of allergies in Japan has been increasing. Certain types of fruit juice and lactic acid bacteria are known to alleviate allergic symptoms. Therefore, we examined whether citrus juice fermented by a specific lactic acid bacteria can improve the symptoms of Japanese cedar pollinosis (JCPsis). Lactobacillus plantarum YIT 0132 (LP0132) was selected based on its high proliferative activity in citrus juice and anti-inflammatory interleukin-10-inducing activity. Dietary administration of heat-killed LP0132 cells or citrus juice fermented with LP0132 was found to significantly suppress nasal rubbing in a JCPsis mouse model, indicating relief of allergy symptoms. To evaluate the effects of LP0132-fermented citrus juice on pollinosis symptoms and quality of life (QOL) in humans with JCPsis, a single-blind, placebo-controlled, parallel-group clinical trial was conducted. The participants were 42 adults with JCPsis. They ingested 100 mL of sterilized LP0132-fermented citrus juice (active group) or unfermented citrus juice (placebo group) once daily for 8 weeks. Immediately after the pollen peak when allergy symptoms and QOL loss were most severe, itchy eyes, itchy skin, and QOL loss by JCPsis were alleviated in the active group compared with the placebo group. At 10 weeks after starting the intervention, increased the levels of blood eosinophils were significantly suppressed in the active group compared with the placebo group. We conclude that continuous ingestion of citrus juice fermented with LP0132 may help alleviate the allergy symptoms and impaired QOL caused by JCPsis.

Effects of citrus juice fermented with <i>Lactobacillus plantarum</i> YIT 0132 on Japanese cedar pollinosis during probiotic consumption: an open study

“…Both JCPsis symptoms and impaired QOL were alleviated in the LP0132-supplemented group. The results suggest that subjects with JCPsis symptoms who consumed LcS-fermented milk also received the same benefits from LP0132-fermented juice as those who did not consume LcS-fermented milk [9]. A previous study showed that ingestion of LcS-fermented milk by JCPsis patients delayed the occurrence of nasal symptoms [14].…”

“…Lactobacillus plantarum YIT 0132 (LP0132) potentially induces a high level of IL-10 secretion in vitro, and previous clinical trials showed that LP0132-fermented citrus juice containing heat-killed LP0132 attenuated JCPsis and other allergic symptoms [9][10][11][12]. In contrast, Lactobacillus casei Shirota (LcS) has high IL-12 productivity in macrophages [13], and daily intake of fermented milk containing LcS delays the onset of JCPsis symptoms [14].…”

Effect of body composition intake with nano-lactic acid in rats

“…Also, probiotics were shown to be effective in the maintenance of remission therapy targeting colonic inflammation in ulcerative coltis or pouchitis patients [14], and to be alleviated symptom of pollinosis when yogurt supplemented with a probiotic strain was given to moderate Japanese cedar pollinosis patients [15], lactic acid bacteria as probiotics was found to have immunomodulatory effects. These effect are effectiveness of probiotic strain, it has been confirmed to even effect in the heat-killed lactic acid bacteria [16]. In addition, these lactic acid bacteria are potentially to be suppressed the increase of weight gain and body fat [17].…”

Potential of lactic acid bacteria as suppressors of wine allergies

“…In a study conducted in Japan, patients with cedar pollinosis allergy were treated with citrus juice fermented by Lactobacillus plantarum YIT 0132. As a results allergic symptoms were alleviates [37].…”