Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients

Kim, Youngjoo; Shin, Young-Oh; Bae, Jun-Sang; Lee, Jeong‐Beom; Ham, Joo-Hyun; Son, Youn‐Jung; Kim, Jung-Kyu; Kim, Chul; Lee, Byoung Kwon; jaekeun, oh; Othman, Timothy; Min, Young‐Ki; Yang, Hye-Won

doi:10.1007/s00424-007-0356-6

Cited by 46 publications

(40 citation statements)

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“…National and regional surveys, such as the CARINEX Survey, 33 53 Kuwait, 54 Latvia, 55 Lithuania,34 Luxembourg, 34 Netherlands, 34 New Zealand, 56 Norway, 57 Poland, 34 Portugal, 34 Puerto Rico, 58 Qatar, 59 Russian Federation, 34 Singapore, 60 Slovak Republic, 34 Slovenia, 61 Spain, 33 Sweden, 34 Switzerland, 62 Trinidad and Tobago, 63 United Arab Emirates, 64 United Kingdom, 65 United States, 66 Uruguay, 42 and the Virgin Islands (U.S.). 67 …”

Section: Cr Availability In High-income Countriesmentioning

confidence: 99%

Global availability of cardiac rehabilitation

2014

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The most prevalent non-communicable disease globally, namely cardiovascular disease (CVD), is also the leading cause of mortality, with over 80% of the deaths occurring in low-and middleincome countries. To lessen the impact of CVDs on individuals and societies, a comprehensive approach is needed. Cardiac rehabilitation (CR) involves delivery of structured exercise, education and risk reduction, in a cost-effective manner. Robust evidence demonstrates it reduces mortality up to 25%, improves functional capacity, as well as decreases re-hospitalization. Despite its benefits, and clinical practice guideline recommendations to refer cardiac patients, CR programs are grossly under-used. Worldwide, there is low availability of CR; only 38.8% of countries globally have CR programs. Specifically, 68.0% of high-income and 23% of LMICs (28.2% for middle-and 8.3% for low-income countries) have CR. CR density estimates ranged from 1 program per 0.1-6.4 million inhabitants. CR availability is much lower than that of other evidencebased secondary prevention therapies, such as revascularization and pharmacological therapies. Multi-level strategies to augment CR capacity and availability at national and international levels such as supportive public health policies, systematic referral strategies, and alternative models of delivery are needed.

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Section: Cr Availability In High-income Countriesmentioning

confidence: 99%

Global availability of cardiac rehabilitation

2014

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“…Several prospective studies [289][290][291][292][293][294] examining the influence of exercise training alone or incorporated in more composite approaches associated to cardiac rehabilitation programs or other lifestyle interventions on markers of inflammation, have suggested an anti-inflammatory effect of chronic exercise (see Table 1). However, the majority of those studies are nonrandomized, uncontrolled, and observational.…”

Section: Effects Of Regular Physical Exercise On Crp and Other Inflammentioning

confidence: 99%

Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis

Pinto¹,

Raimondo

Tuttolomondo³

et al. 2012

CPD

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Abstract:It is well established that physically fit individuals have a reduced risk of developing CVD (cardiovascular disease) and other age-related chronic disorders. Regular exercise is an established therapeutic intervention with an enormous range of benefits. Chronic low-grade systemic inflammation may be involved in atherosclerosis, diabetes and in pathogenesis of several chronic pathological conditions; recent findings confirm that physical activity induces an increase in the systemic levels of a number of cytokines and chemokines with anti-inflammatory properties. The possibility that regular physical exercise exerts anti-inflammation activity, being the interaction between contracting muscle and the other tissues and the circulating cells mediated through signals transmitted by "myokines" produced with muscle contractions. To date the list of myokines includes IL-6, IL-8, and IL-15. During muscle contractions are also released IL1receptor antagonis and sTNF-R, molecules that contribute to provide anti-inflammatory actions.Nevertheless discrepancies, analysis of available researches seem to confirm the efficacy of regular physical training as a nonpharmacological therapy having target chronic low-grade inflammation. Given this, physical exercise could be considerate a useful weapon against local vascular and systemic inflammation in atherosclerosis. Several mechanisms explain the positive effect of chronic exercise, nevertheless, these mechanisms do not fully enlighten all pathways by which exercise can decrease inflammation and endothelial dysfunction, and hence modulate the progression of the underlying disease progress.

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“…However, the basic mechanisms behind this positive impact are not fully understood. Several studies [13][14][15][16][17] have recently highlighted the important role of exercise in the mitigation of endothelial dysfunction and vascular inflammation, giving rise to a new set of potential explanations for the beneficial outcomes of regular exercise in CAD patients. Thus, the purpose of this study is to provide a critical review of the literature linking exercise, inflammation, and endothelial dysfunction in CAD patients, and to discuss the potential mechanisms underlying the exercise-training improvement of endothelial function and inflammatory status.…”

Section: Introductionmentioning

confidence: 99%