Beneficial effect of dinitrosyl iron complexes with thiol ligands on the rat penile cavernous bodies

Велиев, Е. И.; Котов, С. В.; Shishlo, V. K.; Сереженков, В. А.; Lozinsky, V. I.; Vanin, A. F.

doi:10.1134/s0006350908020061

Cited by 9 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNICs with glutathione increase survival, improve myocardial function, and stimulate microcirculation in animals at hemorrhagic shock [ 23 ]. Moreover, DNIC with cysteine or glutathione accelerate skin wound healing [ 24 ], improve the function of cavernous tissue, and suppress its fibrous transformation in rats with denervated penis [ 25 , 26 ]. Moreover, they induce persistent erection of the penis in rats both at innervation and after surgical denervation [ 25 , 26 ].…”

mentioning

confidence: 99%

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Vanin

Burbaev

2011

Journal of Biophysics

View full text Add to dashboard Cite

The ability of mononuclear dinitrosyl iron commplexes (M-DNICs) with thiolate ligands to act as NO donors and to trigger S-nitrosation of thiols can be explain only in the paradigm of the model of the [Fe+(NO+)2] core ({Fe(NO)2}7 according to the Enemark-Feltham classification). Similarly, the {(RS−)2Fe+(NO+)2}+ structure describing the distribution of unpaired electron density in M-DNIC corresponds to the low-spin (S = 1/2) state with a d7 electron configuration of the iron atom and predominant localization of the unpaired electron on MO(dz2) and the square planar structure of M-DNIC. On the other side, the formation of molecular orbitals of M-DNIC including orbitals of the iron atom, thiolate and nitrosyl ligands results in a transfer of electron density from sulfur atoms to the iron atom and nitrosyl ligands. Under these conditions, the positive charge on the nitrosyl ligands diminishes appreciably, the interaction of the ligands with hydroxyl ions or with thiols slows down and the hydrolysis of nitrosyl ligands and the S-nitrosating effect of the latter are not manifested. Most probably, the S-nitrosating effect of nitrosyl ligands is a result of weak binding of thiolate ligands to the iron atom under conditions favoring destabilization of M-DNIC.

show abstract

mentioning

confidence: 99%

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Vanin

Burbaev

2011

Journal of Biophysics

View full text Add to dashboard Cite

show abstract

“…Moreover, treatment with this drug protected the denervated cavernosum tissue against its transformation into fibrosis tissue in rats. 181 The preparation was shown to have low toxicity, and no mutagenic or pro-apoptotic activity of the drug was found so far.…”

Section: Dnic Occurrence and Functions In The Tissue; Medical Implica...mentioning

confidence: 98%

Nitrosyl iron complexes—synthesis, structure and biology

et al. 2011

View full text Add to dashboard Cite

Nitrosyl complexes of iron are formed in living species in the presence of nitric oxide. They are considered a form in which NO can be stored and stabilized within a living cell. Upon entering a topic in bioinorganic chemistry the researcher faces a wide spectrum of issues concerning synthetic methods, the structure and chemical properties of the complex on the one hand, and its biological implications on the other. The aim of this review is to present the newest knowledge on nitrosyl iron complexes, summarizing the issues that are important for understanding the nature of nitrosyl iron complexes, their possible interactions, behavior in vitro and in vivo, handling of the preparations etc. in response to the growing interest in these compounds. Herein we focus mostly on the dinitrosyl iron complexes (DNICs) due to their prevailing occurrence in NO-treated biological samples. This article reviews recent knowledge on the structure, chemical properties and biological action of DNICs and some mononitrosyls of heme proteins. Synthetic methods are also briefly reviewed.

show abstract

Prospects of using magnetic nanoparticles to potentiate the anticarcinogenic action of dinitrosyl iron complexes with thiol ligands

Vanin

2011

BIOPHYSICS

View full text Add to dashboard Cite

Beneficial effect of dinitrosyl iron complexes with thiol ligands on the rat penile cavernous bodies

Cited by 9 publications

References 27 publications

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Nitrosyl iron complexes—synthesis, structure and biology

Prospects of using magnetic nanoparticles to potentiate the anticarcinogenic action of dinitrosyl iron complexes with thiol ligands

Contact Info

Product

Resources

About