Belamcandaquinones A and B, novel dimeric 1,4-benzoquinone derivatives possessing cyclooxygenase inhibitory activity

Dimeric 1,4-benzoquinone Derivatives with Cytotoxic Activities from the Marine-Derived Fungus Penicillium sp. L129

“…Key HMBC connections of 2-OCH 3 /C-2, 4’-OCH 3 /C-4’, 5’-OCH 3 /C-5’, 6’-CH 3 /C-1’, 6’-CH 3 /C-5’, and 6’-CH 3 /C-6’ and the chemical shift of C-2’ established that the phenol fragment of compound 1 was 3,4-dimethoxy-5-methylphenol ( 6 ) [12]. The 1,4-benzoquinone ring system was also confirmed by HMBC and NOESY correlations, which was further supported by comparing its NMR data with those of reported derivatives [23,24]. Compound 1 , as a new compound containing a dimeric 1,4-benzoquinone motif and a phenol fragment, was thus elucidated as 2’-hydroxy-2,4’,5’-trimethoxy-6,6’-dimethyl-(5,1’-biphenyl)-1,4-dione.…”

Iron catalyzed C–C dehydrogenative coupling reaction: synthesis of arylquinones from quinones/hydroquinones

“…For example, Belamcanda chinensis , were used as a specific cyclooxygenase inhibitor, belamcandaquinones A and B isolated from the seed of a medicinal plant. 7 Furthermore, aryl-substituted quinones are very useful in the dye industry owing to their important coloring properties. 8 Thus, the synthesis of aryl substituted quinones has attracted significant attention and many methods have been developed.…”

Phenolic Compounds from Belamcanda chinensis Seeds

“…The dried rhizomes of B. chinensis have been used for the treatment of sore throat and pharyngitis in traditional Chinese medicine [ 1 ]. Benzoquinones, flavonoids, isoflavonoids, phenols, iridal-type triterpenoids, and steroids have been characterized from B. chinensis [ 2 , 3 , 4 ]. Among them, flavonoids and isoflavonoids were reported to be the main compounds, which showed a wide range of pharmacological activities such as antibacterial, anti-inflammatory, and antioxidant activity [ 5 ].…”