Phenolic Compounds from Belamcanda chinensis Seeds

Song, Yingying; Liu, Ying; Yan, Yong‐Ming; Lu, Xifeng; Cheng, Yong‐Xian

doi:10.3390/molecules23030580

Cited by 10 publications

(6 citation statements)

References 27 publications

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“…Once squalene is generated, SQLE catalyzes its epoxidation to 2,3-oxidosqualene (squalene epoxide). This is the first reaction of the cholesterol-specific biosynthetic pathway; furthermore, SQLE is considered as one rate-limiting enzyme of this same pathway [ 31 , 40 ]. In light of this, FDFT1 and SQLE are looked upon as perspective molecular targets for the development of novel lowering cholesterol drugs [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

RNA Sequencing-Based Whole-Transcriptome Analysis of Friesian Cattle Fed with Grape Pomace-Supplemented Diet

Iannaccone

Elgendy

Giantin

et al. 2018

Animals

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Simple SummaryGrape pomace (GPO) is an important source of polyphenols which are known to have antioxidant properties. In the past decade, GPO has received some attention as a bioactive dietary component in farm animals’ diet. In this study, we have analyzed the whole-transcriptome of Friesian calves fed with a GPO-supplemented diet using RNA-sequencing. We noted that the most affected pathway was the cholesterol lipid biosynthesis and this effect was consistent with a reduction in both serum cholesterol and lipid oxidation in the carcasses. This study provides evidence on the antioxidant property of GPO-supplemented diet, from a molecular biology standpoint.AbstractGrape pomace (GPO), the main by-product of the wine making process, is a rich source of polyphenols with potent antioxidant properties. Recently, GPO has emerged as a potential feed additive in livestock nutrition, with several reports describing its beneficial effects on animals’ overall health status or production traits. However, little is known about it from a molecular biology standpoint. In the present study, we report the first RNA sequencing-based whole-transcriptome profiling of Friesian calves fed with a GPO-supplemented diet. We identified 367 differentially expressed genes (p < 0.05) in the GPO-supplemented calves (n = 5), when compared with unsupplemented control group (n = 5). The pathway analysis showed that ‘cholesterol lipid biosynthesis’ was the most negatively-enriched (p < 0.001) pathway in the GPO-supplemented animals. In specific terms, five important genes coding for cholesterol biosynthesis enzymes, namely the Farnesyl-diphosphate Farnesyltransferase 1 (FDFT-1), Squalene Epoxidase (SQLE), NAD(P)-dependent Steroid Dehydrogenase-like (NSDHL), Methylsterol Monooxygenase (MSMO)-1, and Sterol-C5-desaturase (SC5D), two major transcription factors (the Sterol Regulatory Element-binding Transcription Factor 1 and 2), as well as the Low-Density Lipoprotein Receptor (LDLR), were all downregulated following GPO supplementation. Such an effect was mirrored by a reduction of blood cholesterol levels (p = 0.07) and a lowered (p < 0.001) Malondialdehyde (lipid oxidation marker) level in carcasses. We provide evidence on the effects of GPO-supplemented diets on the whole-transcriptome signature in veal calves, which mainly reflects an antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

RNA Sequencing-Based Whole-Transcriptome Analysis of Friesian Cattle Fed with Grape Pomace-Supplemented Diet

Iannaccone

Elgendy

Giantin

et al. 2018

Animals

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“…B. chinensis is a traditional Chinese medicinal plant, belongs to the Iridaceae family and commonly found in northeast Asia region [ 60 , 61 ]. The biological activity of this plant include antitumor, antioxidant, antidiabetic, estrogen-like, hepatoprotective, antibacterial, and anti-inflammatory [ 61 ]. It contains several bioactive compounds like flavonoids, terpenoids, organic acids, and quinones [ 62 ].…”

Section: Major Medicinal Plants With Anticancer Activities and Possib...mentioning

confidence: 99%

“…Belamcanda chinensis L. (B. chinensis). B. chinensisis a traditional Chinese medicinal plant, belongs to the Iridaceae family and commonly found in northeast Asia region [60,61]. The biological activity of this plant include antitumor, antioxidant, antidiabetic, estrogen-like, hepatoprotective, antibacterial, and anti-inflammatory [61].…”

Section: Camptotheca Acuminata Decne (C Acuminata)mentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fight against cancer. Moreover, researches in the field of plant-based natural compounds have moved towards advanced and molecular level understandings from the last few decades, leading to the development of potent anticancer agents. Also, plants have been accepted as abundant and prosperous sources for the development of novel therapeutic agents for the management and prevention of different cancer types. The high toxicity of some cancer chemotherapy drugs, as well as their unfavorable side effects and drugs resistance, drives up the demand for natural compounds as new anticancer drugs. In this detailed evidence-based mechanistic review, facts and information about various medicinal plants, their bioactive compounds with their potent anticancer activities against different cancers have been gathered, with further approach to represent the molecular mechanism behind the anticancer activity of these plants. This review will be beneficial for investigators/scientists globally involved in the development of natural, safe, effective, and economical therapeutic agents/drugs against various cancers. This might be an important contribution in the field of drug discovery, where drugs can be used alone or in combination to increase the efficacy of newly synthesized drugs.

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“…For this study, treatment with 9,10-PQ negatively affected steroid biosynthesis because all DEGs, including squalene epoxidase (SQLE), methylsterol monooxygenase 1 (MSMO1), CYP51A1, and 24-dehydrocholesterol reductase (DHCR24) (P Ͻ 0.05, Supplementary Table S3), were downregulated in the liver. SQLE is a rate-limiting enzyme that catalyzes the first reaction of cholesterol-specific biosynthesis (72) and a promising molecular target for the development of novel cholesterol-lowering drugs (77). MSMO1 is involved in the oxidation-reduction process and has been associated with metabolic disease in humans (23).…”

Section: Resultsmentioning

confidence: 99%

Transcriptome changes ofTakifugu obscurusliver after acute exposure to the oxygenated-PAH 9,10-phenanthrenequione

Jiang

Yang

Fang

2020

Physiological Genomics

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Contamination with polycyclic aromatic hydrocarbons (PAHs) causes noticeable ecological problems in aquatic ecosystems. 9,10-phenanthrenequione (9,10-PQ) is an oxidized PAH and is highly toxic to aquatic animals. However, the effects of 9,10-PQ on the molecular metabolism of fish remain largely unknown. In this study, Takifugu obscurus juveniles were acutely exposed to 44.30 µg/L 9,10-PQ for three days. The transcriptome profile changes in their livers were compared between the 9,10-PQ treatment group and the control using T. rubripes as the reference genome. The results identified 22,414 genes in our transcriptome. Among them, 767 genes were differentially expressed (DEGs) after exposure to 9,10-PQ, which enriched 16 KEGG pathways. Among them, the glycolysis, phagosome, and FOXO signaling pathways were significantly activated in 9,10-PQ treatment compared with the control. These data indicate that 9,10-PQ increased the glycolysis capacity to produce more energy for resistance and harmed immune function. Moreover, several genes related to tumorigenesis were significantly up-regulated in response to 9,10-PQ, displaying the carcinogenic toxicity of 9,10-PQ to T. obscurus. Genes in steroid biosynthesis pathways were down-regulated in the 9,10-PQ treatment group, suggesting interference with the endocrine system. Overall, these findings provide information to help evaluate the environmental risks that oxygenated-PAHs present to T. obscurus.

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Phenolic Compounds from Belamcanda chinensis Seeds

Cited by 10 publications

References 27 publications

RNA Sequencing-Based Whole-Transcriptome Analysis of Friesian Cattle Fed with Grape Pomace-Supplemented Diet

RNA Sequencing-Based Whole-Transcriptome Analysis of Friesian Cattle Fed with Grape Pomace-Supplemented Diet

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Transcriptome changes ofTakifugu obscurusliver after acute exposure to the oxygenated-PAH 9,10-phenanthrenequione

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