Beiträge zur Kenntniss der pathologischen Pigmente

Neumann, E.

doi:10.1007/bf01924848

Cited by 61 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13 In 1869 erythrophagocytosis was detected in haemorrhages, 14 and in 1888 the iron containing pigment in old haemorrhages was named haemosiderin and diVerentiated from haematoidin. 15 The earliest change seen microscopically in the development of a bruise is oedema, resulting in fluid exudation within the vicinity of the haemorrhage, together with widening of fibrous septa. This early, non-cellular exudative phase merges into the leucocyte reaction.…”

Section: Microscopical Changes In Bruisesmentioning

confidence: 99%

Interpreting bruises at necropsy

Vanezis

2001

Journal of Clinical Pathology

View full text Add to dashboard Cite

The accurate interpretation of bruising at necropsy is essential to understanding how a victim has been injured and assists the pathologist in a reliable reconstruction of the events leading to death. It is essential not only to assess the mechanism of production of a bruise, taking into account the type of impacting surface and the magnitude of force used, but also to estimate when the injury was caused. An account is given of the various methods used in the examination of bruises, particularly with respect to aging, as well as the factors that may aVect their appearance. DiVerentiation from artefacts resulting from postmortem changes is also discussed in some detail. (J Clin Pathol 2001;54:348-355) Keywords: bruising; necropsy; time of death; cause of death The interpretation of bruising for forensic purposes requires the pathologist to bear in mind the following three fundamental questions: + Is the discolouration seen a bruise? + When was it caused? + How was it caused?A succinct definition of a bruise is that it is a collection of blood, visible to the naked eye as an area of discolouration, which has extravasated into the surrounding tissues after vascular disruption, principally as a result of trauma or occasionally spontaneously, as a result of a disease process. Typically, bruises are caused by blunt trauma, although they may be associated with any type of impact and can accompany many diVerent types of wounds. Thus, they can provide much information with regard to their causation and can assist with the reconstruction of events leading to death.Furthermore, when an injury is inflicted and blood extravasates from injured blood vessels the resultant bruising may be: + Located at the area of impact and visible shortly after infliction of the injury. + Located at the area of impact area but delayed in appearance. + Located at a site away from the impact area and result from tracking of blood from the impact area. The word bruise is often used synonymously with the term haematoma and ecchymosis (or ecchymoma). Contusion is also another frequently used term, particularly in relation to internal trauma.Although bruising is most often thought of as an extravasation of blood intradermally or subcutaneously, bruises can occur almost anywhere in the body. Factors that influence the development and appearance of bruisesThere are many variables that influence the development and absorption of bruises, as well as their appearance and extent of spread, thus adding to the diYculty in their interpretation.Bruising occurs more easily where there is loose tissue-for example, over the eyebrowrather than where the skin is more strongly supported. It also occurs more readily where there is an excess of subcutaneous fat. Because there is a greater skin deposition of fat in women, they tend to bruise more easily than do men.The type of surface and force that impacts on the body will have a great eVect on the intensity, size, shape, and pattern of the resultant bruising.In infants and the elderly bruising tends to o...

show abstract

Section: Microscopical Changes In Bruisesmentioning

confidence: 99%

Interpreting bruises at necropsy

Vanezis

2001

Journal of Clinical Pathology

View full text Add to dashboard Cite

show abstract

“…The conversion of blood pigment to hemosiderin requires contacr with living tissue [ 12). The incrustation of the external and internal surfaces of the CNS is the final result of the following sequence of cellular and biochemical events:…”

Section: The Conversion Of Hemoglobin To Hemasidrrinmentioning

confidence: 99%

The pathogenesis of superficial siderosis of the central nervous system

Koeppen

Dickson

Chu

et al. 1993

Annals of Neurology

142

108

View full text Add to dashboard Cite

In advanced cases of superficial siderosis of the human central nervous system, the clinical triad of hearing loss, cerebellar ataxia, and myelopathy permits the diagnosis at the bedside, and magnetic resonance imaging readily confirms the hemosiderin deposits in brainstem, cerebellum, and spinal cord. To study the pathogenesis of this condition and explain the selective vulnerability of the cerebellum, experimental siderosis was induced in rabbits by the repeated intracisternal injection of autologous red blood cells. The earliest cellular response in the cerebellar molecular layer was hyperplasia and hypertrophy of microglia as displayed by immunocytochemistry for ferritin. Microglia also contained iron, but ferritin biosynthesis appeared to proceed without commensurate iron accumulation. This early apoferritin response probably occurred due to the presence of heme, rather than iron, in the cerebrospinal fluid and subpial tissue. Ferritin biosynthesis is accelerated when the ferritin repressor protein is dissociated from ferritin messenger ribonucleic acid. A specific antiserum localized ferritin repressor protein predominantly to astrocytes including Bergmann glia. It is proposed that abundance and proximity of ferritin repressor protein--immunoreactive Bergmann glia and ferritin-containing microglia in the cerebellar molecular layer permit prompt cellular interaction in the conversion of heme to ferritin and ultimately hemosiderin.

show abstract

“…The term``hemosiderin'' was coined by Neumann [ 33] in 1988 to describe the iron-rich pigment that developed after extravasation of blood ( and it is hemosiderin formed in this fashion that is principally discussed here) . This was followed by the usual plethora of conflicting histochemical studies.…”

Section: Siderosomes Hemosiderin Vs Ferritinmentioning

confidence: 99%

As You Like It, Part 2: A Critique and Historical Review of the Electron Microscopy Literature

Ghadially

1999

Ultrastructural Pathology

View full text Add to dashboard Cite

As You Like It, Part 2, is a continuation of the lecture given at UltraPath VIII in 1996. It is meant to be a critical historical review of some topics of interest to electron microscopists that will show what went wrong and perhaps also why. Topics are presented under the following headings : (1) Amianthoid Fibers and Giant Collagen Fibrils, (2) Ribosome-Lamella Complex, (3) Globular Filamentous Bodies, and (4) Siderosomes, Hemosiderin vs. Ferritin.

show abstract

Beiträge zur Kenntniss der pathologischen Pigmente

Cited by 61 publications

References 2 publications

Interpreting bruises at necropsy

Interpreting bruises at necropsy

The pathogenesis of superficial siderosis of the central nervous system

As You Like It, Part 2: A Critique and Historical Review of the Electron Microscopy Literature

Contact Info

Product

Resources

About