Beitrag zur Problematik des Lp-Systems

The Mysteries Of Lipoprotein(a)

“…It now emerges that variation at the apo(a) locus also relates to susceptibility to coronary heart disease. Numerous epidemiological studies have all found a positive association of plasma Lp(a) concentrations with premature myocardial infarction (5). For individuals with plasma Lp(a) concentrations exceeding 50 milligrams per deciliter and for those with concomitantly high LDL concentrations, the relative risk for early coronary heart disease may be increased up to sixfold.…”

“…Although Lp(a) was characterized in some detail already in the early 1970s (3), little attention was paid for almost two decades to this macromolecular complex that is assembled from LDL and a high molecular mass glycoprotein called the Lp(a) glycoprotein or apolipoprotein(a) [apo(a)] (4). Numerous studies suggested an association of plasma Lp(a) concentrations with atherosclerotic vascular disease (5,6). However, only the recent discovery of the strong homology of apo(a) to plasminogen (7,8) has stimulated intensive research in the genetics, metabolism, function, and disease association of Lp(a).…”

Polymorphisms of the Human Low-Density Lipoproteins

“…The significantly lower frequency of Lp(a+) sera in pregnant women and patients with hepatic diseases observed by Jörgensen et al [36] might be due to this fact. Furthermore Renninger et al [43] observed with their anti-Lp-serum strong positive and weak positive reactions which proved to be easily reproducable ; the authors do not exclude the possibility that the weak types are genetically controlled by a special gene (Lpas). On the other hand, falsely positive readings are equally possible, artefacts being taken for LDL-anti-LDL-precipitation lines.…”

“…It might be that here again, as in case of the production of the anti-Ag-antibodies, the spleen plays a predominant role. Beside Berg only Seidl et al [45], Renninger et al [43] and Jörgensen et al [36] have reported suc cessful heteroimmunizations with rabbits. The different authors do not mention how many animals had to be used in order to obtain one Lp-specific heteroprecipitin.…”

Lp(a) phenotyping by immunoblotting with polyclonal and monoclonal antibodies.

“…2 " 5 The interest in this unusual lipoprotein was greatly stimulated by reports of an association of high levels of Lp(a) lipoprotein with atherosclerosis. 6 " 11 The Lp(a) lipoprotein is an LDL-like particle that floats in a density range of about 1.05 to 1.10 g/ml. The lipid composition is similar to that of the LDL particle, but its protein moiety contains, in addition to apo B-100, the Lp(a)-specific glycoprotein, which is linked to apo B by disulfide bonds.…”