The Mysteries Of Lipoprotein(a)

Utermann, Gerd

doi:10.1126/science.2530631

Cited by 1,190 publications

(636 citation statements)

References 66 publications

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“…The molecular mass of Lp(a) is approximately 3.8 x lo6 121. Plasma Lp(a) levels are positively correlated with atherosclerosis (see [3] for review) and is an independent risk factor for myocardial infarction [4-81. The amino acid sequence of apolipoprotein(a) has a high degree of homology with plasminogen.…”

Section: Introduction 2 Materials and Methodsmentioning

confidence: 99%

Lipoprotein(a) enhances plasma clot lysis in vitro

Mao¹,

Tucci²

1990

FEBS Letters

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Human plasma lipoprotein(a) (Lp(a)) is a macromolecular complex that contams a protem homologous to plasminogen. the precursor of plasmin. We confirmed recent reports that Lp(a) is not activated by streptokinase or tissue plasminogen activator (t-PA) to yreld plasmm-like activtty. In testing the hypothesis that Lp(a) can competittvely inhabit plasma clot lys~s medtated by plasmm, the present study shows that Lp(a) stgmficantly enhanced plasma clot lysis mediated by streptokmase or t-PA The enhancement, however, was not observed in a plasmm-medtated clot lysts usmg a purtfied fibrinogen system. The addttion of x-,-anttplasmm (%-plasmin inhibitor) to thts system inhtbited tibrinolysts: however, no inhibition was observed in the presence of Lp(a). One potential explanation for the Lp(a)-enhanced plasma clot lysis is that Lp(a) neutrahzes the activtty of a,-antiplasmm present m plasma, thereby restormg the acttvtty of plasmm to lyse the clot.Ltpoprotein(a); Plasmmogen; Fibrmolysis; %-Plasmm mhtbttor; a,-Antiplasmin

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Section: Introduction 2 Materials and Methodsmentioning

confidence: 99%

Lipoprotein(a) enhances plasma clot lysis in vitro

Mao¹,

Tucci²

1990

FEBS Letters

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“…High levels of lipoprotein(a), a plasma lipoprotein complex composed of apolipoprotein(a) [apo(a)] covalently linked to apoB-100, have been associated with early atherosclerotic vascular disease (Hoefler et al 1988;Rhoads et al 1986;Utermann 1989). Serum Lp(a) has been identified as an independent risk factor for myocardial infarction (Rhoads et al 1986), and also for atherogenesis and thromboembolytic events (Scott 1989).…”

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confidence: 99%

The association of hyperlipidemia with retinopathy in diabetic patients aged 15‐50 years in the county of Umeå

Alm

Lithner

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To study possible associations between serum lipid levels and degree of retinopathy in a population-based study on a specific age-group of patients with diabetes mellitus in the county of Umeå, Sweden. Methods: All patients with diabetes mellitus aged 15-50 years living in the county of Umeå were invited to the study. The participating subjects had a standard clinical examination and an eye examination performed. Seven-field stereoscopic photographs were taken of each eye, and the photos were sent to Grading Center, Hammersmith Hospital, London, U.K. for grading of the retinopathy. Blood samples were drawn for analysis of lipoprotein(a), high density lipoprotein (HDL) cholesterol, cholesterol and triglycerides. Univariate and multivariate statistical analyses were performed. Results: In the present study only patients with type 1 diabetes mellitus were included, and 285 of the invited 308 diabetic subjects (93%) took part. When univariate analysis was applied we found statistically significant associations between higher lipoprotein(a) levels, higher triglyceride levels, higher cholesterol levels, lower HDL cholesterol/total cholesterol ratios and increasing severeness of retinopathy. However, in the multivariate analysis triglyceride levels lost their importance while all other significant associations were still present. Conclusion: Associations were found between higher levels of serum total cholesterol, declining ratios of high density lipoprotein (HDL) cholesterol/total cholesterol, higher levels of serum lipoprotein(a) and more severe retinopathy in diabetes mellitus type 1. No such association was found between serum triglycerides and degree of retinopathy.

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“…Both the mean Lp(a) concentration and the impact of apo(a) size polymorphism on Lp(a) concentration are heterogenous across populations (13). The relation of apo(a) isoforms to Lp(a) concentrations has been extensively studied in different ethnic groups.…”

Section: Author For Correspondencementioning

confidence: 99%

LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls

Luthra

Vasisht

Chhabra

et al. 1998

Indian J Clin Biochem

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Lipoprotein Lp(a) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. To evaluate this in a North-Indian population, 130 CAD patients and 130 controls were analyzed. The size of the apo(a) phenotypic isoforms was inversely proportional to Lp(a) concentrations. The mean concentration of Lp(a) in the CAD patients was 42+34 mg/dl whereas in the normal subjects it was much lower, 27+27 mg/dl. 157 subjects out of the total 260 subjects showed plasma levels of > 20mg/dl. The frequency of high Lp(a) levels was much higher in patients(73%) than controls (43%). These data suggest (1) that there is heterogeneity of the Lp(a) polymorphism, (2) Higher Lp(a) levels were found in patients than in the controls, (3) Patients showed 1.5 fold increase in Lp(a) levels as compared to the controls. We conclude that low molecular weight apo(a) isoforms are significantly associated with increased risk of CAD in the North-Indian population.

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The Mysteries Of Lipoprotein(a)

Cited by 1,190 publications

References 66 publications

Lipoprotein(a) enhances plasma clot lysis in vitro

Lipoprotein(a) enhances plasma clot lysis in vitro

The association of hyperlipidemia with retinopathy in diabetic patients aged 15‐50 years in the county of Umeå

LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls

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